Publications by authors named "Yenny Goez-Rivillas"
Scrub typhus, caused by a Gram-negative obligately intracellular coccobacillus, Orientia tsutsugamushi, is a long neglected but important tropical disease. Orientia tsutsugamushi causes illness in one million people each year, and 1 billion people are at risk. Without appropriate diagnosis and treatment, the disease can cause severe multiorgan failure with a case fatality rate of 7-15%.
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- Scrub typhus is a neglected tropical disease caused by the bacterium Orientia tsutsugamushi, primarily transmitted by Leptotrombidium mites, and it primarily affects endothelial cells.
- Researchers developed an intradermal inoculation model in mice to study the natural infection route, observing host responses and disease progression over time.
- Findings showed early signs of infection such as fever and weight loss, significant immune response indicated by elevated cytokines, and persistent infection in various organs, marking a key advancement in understanding scrub typhus.