Publications by authors named "Yeng Cheng Choo"
In addition to the env gene, a 0.3-kb fragment containing the R-U5-5' leader sequence is essential for the induction of spongiform neurodegeneration by Friend murine leukemia virus (Fr-MLV) clone A8 and it also influences expression of the Env protein. Kinetic studies were carried out using two recombinant viruses, R7f, carrying the A8 0.
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- A neuropathogenic variant of Friend murine leukemia virus (Fr-MLV) induces neurodegeneration in neonatal rats, with a key 0.3-kb fragment from the virus identified as crucial for this effect.
- Research shows that the A8 version of this fragment leads to higher luciferase expression compared to the non-neuropathogenic version, although it doesn't affect other aspects of mRNA processing.
- Mutational analysis highlights seven specific nucleotides in the 0.3-kb fragment that play a significant role in regulating protein expression from spliced messages, indicating their importance in viral behavior.