Publications by authors named "YenWei Chen"

Hyperspectral image (HSI) reconstruction is a critical and indispensable step in spectral compressive imaging (CASSI) systems and directly affects our ability to capture high-quality images in dynamic environments. Recent research has increasingly focused on deep unfolding frameworks for HSI reconstruction, showing notable progress. However, these approaches have to break the optimization task into two sub-problems, solving them iteratively over multiple stages, which leads to large models and high computational overheads.

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This investigation aims to develop an angular stiffness sensor intended for measuring dental implant stability in bone. The sensor hardware included a tiny eccentric motor and an accelerometer to measure a flex constant of an implant with its abutment. The sensor software included a mechanics-based model to convert the flex constant to angular stiffness at the implant/abutment junction to indicate the stability.

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Accurate preoperative recurrence prediction for non-small cell lung cancer (NSCLC) is a challenging issue in the medical field. Existing studies primarily conduct image and molecular analyses independently or directly fuse multimodal information through radiomics and genomics, which fail to fully exploit and effectively utilize the highly heterogeneous cross-modal information at different levels and model the complex relationships between modalities, resulting in poor fusion performance and becoming the bottleneck of precise recurrence prediction. To address these limitations, we propose a novel unified framework, the Self-and-Mutual Attention (SAMA) Network, designed to efficiently fuse and utilize macroscopic CT images and microscopic gene data for precise NSCLC recurrence prediction, integrating handcrafted features, deep features, and gene features.

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Article Synopsis
  • The study investigates the use of whole-liver histogram analysis from Gd-BOPTA-enhanced MRI as a more precise method for evaluating liver function in patients with cirrhosis compared to traditional scoring systems.
  • A total of 117 cirrhosis patients were analyzed, categorized by Child-Pugh classification, and various histogram features were extracted to assess their correlation with liver function.
  • Results showed that five specific histogram features were significantly associated with the development of hepatic insufficiency, indicating the potential of this imaging technique in predicting disease progression.
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Multiple Instance Learning (MIL) has demonstrated promise in Whole Slide Image (WSI) classification. However, a major challenge persists due to the high computational cost associated with processing these gigapixel images. Existing methods generally adopt a two-stage approach, comprising a non-learnable feature embedding stage and a classifier training stage.

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Although contrast-enhanced computed tomography (CE-CT) images significantly improve the accuracy of diagnosing focal liver lesions (FLLs), the administration of contrast agents imposes a considerable physical burden on patients. The utilization of generative models to synthesize CE-CT images from non-contrasted CT images offers a promising solution. However, existing image synthesis models tend to overlook the importance of critical regions, inevitably reducing their effectiveness in downstream tasks.

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Purpose: To investigate how well an implant stability quotient (ISQ) represents resonance frequency.

Materials And Methods: Benchtop experiments on standardized samples that replicated a mandibular premolar site were conducted to correlate an ISQ value and a resonance frequency to synthetic bone density and an incremental insertion torque; then, a frequency spectrum analysis was performed to check the validity of the resonance frequency analysis (RFA). Brånemark Mk III implants (4 × 11.

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Contrast-enhanced computed tomography (CE-CT) images are vital for clinical diagnosis of focal liver lesions (FLLs). However, the use of CE-CT images imposes a significant burden on patients due to the injection of contrast agents and extended shooting. Deep learning-based image synthesis models offer a promising solution that synthesizes CE-CT images from non-contrasted CT (NC-CT) images.

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Article Synopsis
  • A multitask deep learning model was developed to predict microvascular invasion (MVI) and recurrence-free survival (RFS) in hepatocellular carcinoma (HCC) using preoperative MRI scans from 725 patients.
  • The model demonstrated high accuracy in predicting MVI, with AUC values ranging from 0.800 to 0.918 across training and external test sets, and improved radiologists' performance when utilized.
  • For RFS predictions, the model achieved moderate C-index values, indicating potential clinical utility, especially for patients at high risk of MVI and low survival scores, suggesting a need for further prospective studies.
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Microvascular invasion of HCC is an important factor affecting postoperative recurrence and prognosis of patients. Preoperative diagnosis of MVI is greatly significant to improve the prognosis of HCC. Currently, the diagnosis of MVI is mainly based on the histopathological examination after surgery, which is difficult to meet the requirement of preoperative diagnosis.

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Article Synopsis
  • Object detection using CNNs has shown great success in natural images, but poses challenges in medical imaging, particularly for detecting lesions of varying sizes in multi-phase CT images.
  • A new method called MSPA-DLA++ is introduced, which focuses on deep layer aggregation and attention mechanisms to effectively improve liver lesion detection by addressing issues like scale variations.
  • Experimental results indicate that MSPA-DLA++ outperforms existing state-of-the-art methods by approximately 3.7%, demonstrating its effectiveness on public and private medical datasets.
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Olfactory ensheathing cells (OECs) are unique glial cells found in both central and peripheral nervous systems where they support continuous axonal outgrowth of olfactory sensory neurons to their targets. Previously we reported that following severe spinal cord injury, OECs transplanted near the injury site modify the inhibitory glial scar and facilitate axon regeneration past the scar border and into the lesion. To better understand the mechanisms underlying the reparative properties of OECs, we used single-cell RNA-sequencing of OECs from adult rats to study their gene expression programs.

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Alzheimer's disease (AD) is a progressive neurodegenerative disease. Early detection and intervention are crucial in preventing the progression of AD. To achieve efficient and scalable AD auto-detection based on structural Magnetic Resonance Imaging (sMRI), a lightweight neural network using multi-slice sMRI is proposed in this paper.

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  • Reprocessing GI endoscopes and accessories is crucial for patient safety, yet current practices fail to ensure complete cleanliness, with about 5.4% of duodenoscopes still contaminated.
  • The Digestive Endoscopy Society of Taiwan (DEST) has developed updated standards for endoscopic reprocessing to enhance quality control in GI endoscopy centers.
  • These guidelines offer detailed, step-by-step instructions and recommendations based on comprehensive reviews of existing practices and clinical effectiveness to improve patient safety.
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Compared to non-contrast computed tomography (NC-CT) scans, contrast-enhanced (CE) CT scans provide more abundant information about focal liver lesions (FLLs), which play a crucial role in the FLLs diagnosis. However, CE-CT scans require patient to inject contrast agent into the body, which increase the physical and economic burden of the patient. In this paper, we propose a spatial attention-guided generative adversarial network (SAG-GAN), which can directly obtain corresponding CE-CT images from the patient's NC-CT images.

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High early recurrence (ER) rate is the main factor leading to the poor outcome of patients with hepatocellular carcinoma (HCC). Accurate preoperative prediction of ER is thus highly desired for HCC treatment. Many radiomics solutions have been proposed for the preoperative prediction of HCC using CT images based on machine learning and deep learning methods.

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Medical image segmentation is very essential for computer-aided diagnosis in the field of medical imaging. In the last decade, Deep Learning-based frameworks (e.g.

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As the most common malignant tumor worldwide, hepatocellular carcinoma (HCC) has a high rate of death and recurrence, and microvascular invasion (MVI) is considered to be an independent risk factor affecting its early recurrence and poor survival rate. Accurate preoperative prediction of MVI is of great significance for the formulation of individualized treatment plans and long-term prognosis assessment for HCC patients. However, as the mechanism of MVI is still unclear, existing studies use deep learning methods to directly train CT or MR images, with limited predictive performance and lack of explanation.

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According to the 2021 World Health Organization IDH status prediction scheme for gliomas, isocitrate dehydrogenase (IDH) is a particularly important basis for glioma diagnosis. In general, 3D multimodal brain MRI is an effective diagnostic tool. However, only using brain MRI data is difficult for experienced doctors to predict the IDH status.

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Article Synopsis
  • Computer-aided diagnostic methods, particularly using deep learning, have significantly advanced the automatic detection of liver tumors through multi-phase CT images, improving healthcare outcomes.
  • A key challenge in these methods is the need for large amounts of high-quality annotated training data, which is often difficult to obtain in medical imaging.
  • To overcome this, a new adversarial learning strategy is proposed that utilizes Fourier phase components of CT images, enhancing semantic information and eliminating the need for separate annotations for different scan phases, resulting in improved detection performance.
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MRI is crucial for the diagnosis of HCC patients, especially when combined with CT images for MVI prediction, richer complementary information can be learned. Many studies have shown that whether hepatocellular carcinoma is accompanied by vascular invasion can be evidenced by imaging examinations such as CT or MR, so they can be used as a multimodal joint prediction to improve the prediction accuracy of MVI. However, it is high-risk, time-consuming and expensive in current clinical diagnosis due to the use of gadolinium-based contrast agent (CA) injection.

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  • * A systematic computational approach was used to analyze 30 liver transcriptomic datasets from humans and animals to understand the effects of four EDCs (BPA, DEHP, TBT, PFOA) on CMD, revealing shared mechanisms and unique pathways among these chemicals.
  • * Findings indicated that DEHP and PFOA showed consistent genetic signatures linked to CMDs, while TBT displayed distinct gene expressions and the responses to BPA varied significantly across species, highlighting the complexity of EDC impacts.
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  • Caenorhabditis elegans serves as an important model for studying how different organs and cells react to external influences, due to its unique tissue structures.
  • The study introduces a new single-nucleus RNA sequencing (snRNA-seq) method that addresses challenges faced with single-cell RNA sequencing in this organism.
  • The paper provides a detailed protocol for isolating the nuclei of C. elegans, particularly focusing on analyzing gene expression changes following alcohol exposure, with additional information found in the referenced study by Truong et al. (2023).
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A one-step method for synthesizing 3-(Fmoc-amino acid)-3,4-diaminobenzoic acids was used to prepare preloaded diaminobenzoate resin. The coupling of free diaminobenzoic acid and Fmoc-amino acids gave pure products in 40-94% yield without any purification step in addition to precipitation except for histidine. For the proline residue, crude products were collected and used for solid-phase peptide synthesis to give a moderate yield of a pentapeptide.

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