Publications by authors named "Yen-Wen Wu"
Article Synopsis
- The study examined trends in controlling low-density lipoprotein cholesterol (LDL-C) and the use of lipid-lowering drugs among Taiwanese patients with atherosclerotic cardiovascular disease (ASCVD).
- Data was collected from the T-SPARCLE Registry, categorizing ASCVD patients based on their medical history, and analyzed LDL-C levels from 2015-2020 along with therapy patterns.
- Results showed an increase in lipids-lowering drug use, but over 60% of patients still did not meet LDL-C targets, highlighting gaps in following treatment guidelines, particularly for those with acute coronary syndrome or prior interventions.
Article Synopsis
- A study investigated the effectiveness of Ranolazine for chronic angina in a Taiwanese population, specifically those still experiencing symptoms despite conventional treatment.
- The research was a multi-center, randomized, double-blind trial, focusing on how much the exercise treadmill test (ETT) duration improved after 12 weeks of treatment with Ranolazine compared to a placebo.
- Results showed a significant increase in ETT duration for those receiving Ranolazine, with similar safety profiles to previous studies, indicating that adding Ranolazine could enhance exercise performance and tolerance in chronic angina patients.
Inflammation is one of exacerbating factors of diabetic kidney disease (DKD). Upregulated CXCL5 is found in clinical and experimental diabetes studies. This study aimed to investigate the impact and mechanism of CXCL5 on DKD.
View Article and Find Full Text PDFObjectives: Cardiac amyloidosis (CA) is a type of systemic amyloidosis. Amyloid-targeting positron emission tomography (PET) has shown potential as an imaging method for CA. However, the optimal imaging protocol and role of F-florbetaben (FBB) PET in the diagnosis and subtyping of CA have yet to be determined.
View Article and Find Full Text PDFArticle Synopsis
- Fabry disease (FD) is an X-linked lysosomal storage disorder caused by mutations in the α-galactosidase A gene, leading to harmful buildup of glycosphingolipids in various tissues and classified into classic and late-onset phenotypes.
- Classic phenotype shows severely reduced enzyme activity, resulting in a progressive disease with multi-organ issues, while late-onset often presents with milder symptoms and mainly affects the heart due to some remaining enzyme activity.
- Early diagnosis through enzyme testing, imaging, and genotyping is crucial for effective treatment, which includes enzyme replacement therapy and new pharmacological options to prevent irreversible damage and optimize patient care based on genetic and gender considerations.
Article Synopsis
- * The guidelines address various aspects of ASCVD, including chronic coronary syndrome and cerebrovascular diseases, while promoting health education and the management of clinical risk factors like diet, exercise, and smoking.
- * A catchy slogan and a memorable acronym were proposed to reinforce lifestyle changes related to modifiable risk factors, emphasizing the importance of healthy eating, physical activity, and overall well-being for ASCVD prevention.
Dermal white adipose tissue may participate in the wound-healing process. Obesity-mediated chronic low-grade inflammation impairs wound healing by suppressing vascularity. Given that FABP4 is upregulated in the skin tissue of animals with obesity, this study aimed to investigate the effects of FABP4 inhibition on wound healing in mice with high-fat diet-induced metabolic dysfunction in vivo.
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- Shared decision-making (SDM) helps patients understand their medical conditions and treatments, and this study focused on its effects on Taiwanese adults with atrial fibrillation (AF) receiving novel oral anticoagulants (NOACs).
- The study had two stages: the first involved NOAC-naïve participants completing surveys on anxiety and confidence before and after viewing SDM materials; the second compared responses from both NOAC-naïve and dabigatran-experienced participants after they received treatment.
- Results showed that after viewing SDM materials, participants reported reduced anxiety and increased confidence in healthcare professionals, with a majority finding the materials very helpful in making informed decisions about their treatment.
Background: Diabetes and insulin resistance alter the physiological state of serum albumin (SA), which is a prognostic marker for stable coronary artery disease (CAD). However, whether the SA concentration is associated with long-term cardiovascular (CV) outcomes in diabetic patients with stable CAD remains unclear.
Methods: In total, 1148 patients were retrospectively identified from a nationwide multicenter cohort study on patients with stable CAD.
Background: Both the clinical and mechanistic impacts of endocan were not well elucidated especially in coronary artery disease (CAD).
Objective: This study aimed to investigate the prognostic and potential pathological role of endocan for cardiovascular (CV) events in stable CAD patients.
Methods: A total of 1,071 stable CAD patients with previous percutaneous coronary intervention (PCI) were enrolled prospectively in a nationwide Biosignature study.
Objective: Both low serum albumin (SA) concentration and coronary microvascular dysfunction (CMD) are risk factors for the development of heart failure (HF). We hypothesized that SA concentration is associated with myocardial flow reserve (MFR) and implicated in pathophysiological mechanism of HF.
Methods: We retrospectively studied 454 patients undergoing dynamic cardiac cadmium-zinc-telluride myocardial perfusion imaging from April 2018 to February 2020.
Background: To revisit the association between vitamin D deficiency (VDD, defined as serum 25(OH)D < 20 ng/ml) and incident active tuberculosis (TB), after two potentially underpowered randomized trials showed statistically non-significant 13%-22% decrease in TB incidence in vitamin D supplementation groups.
Methods: We prospectively conducted an age/sex-matched case-control study that accounting for body-mass index (BMI), smoking, and other confounding factors to examine the association between VDD and active TB among non-HIV people in Taiwan (latitude 24°N), a high-income society which continues to have moderate TB burden.
Results: We enrolled 62 people with incident active TB and 248 people in control group.
Article Synopsis
- Heart failure (HF) is a major global health issue, with similar death and rehospitalization rates across different types, but previous Taiwanese registries largely focused on hospitalized patients with HF reduced ejection fraction (HFrEF) before 2019, limiting their applicability to other types.
- The Taiwan Society of Cardiology Heart Failure Registry 2020 aims to enroll 3,370 patients from 27 hospitals, including both inpatients with acute decompensated HF and outpatients who were hospitalized within the last six months, and will collect detailed health data over a two-year follow-up.
- This registry is designed to provide insights into the epidemiology, guideline adherence, clinical outcomes, and disease progression for patients with all HF
Article Synopsis
- Heart failure with preserved ejection fraction (HFpEF) is a complex condition affecting the heart and other organs, leading to significant health issues, especially in younger patients in Asia with high rates of diabetes and kidney disease.
- The diagnosis involves a 2-step algorithm focusing on symptoms, ejection fraction, natriuretic peptide levels, and tests for heart abnormalities; if uncertain, additional stress testing may be required.
- Management includes controlling comorbidities, lifestyle changes like weight loss and exercise, and pharmacological treatments such as diuretics and SGLT2 inhibitors to improve patient outcomes.
Objective: To investigate whether hypotensive patients diagnosed with heart failure and reduced ejection fraction (HFrEF) might benefit from angiotensin receptor-neprilysin inhibitors (ARNis) in real-world practice because patients with baseline systolic blood pressure (SBP) of less than 100 mm Hg have been excluded from landmark trials.
Patients And Methods: In this multicenter study conducted between January 1, 2013, and December 31, 2021, a total of 7562 symptomatic patients with HFrEF were enrolled and grouped by SBP (hypotension was defined as an SBP of less than 100 mm Hg) and ARNi use as follows: group 1, hypotensive/non-ARNi users (n=484); group 2, hypotensive/ARNi users (n=308); group 3, nonhypotensive/non-ARNi users (n=4560); and group 4, nonhypotensive/ARNi users (n=2210). Inverse probability of treatment weighting was used to balance baseline characteristics for survival analysis.
Exercise capacity-hemodynamics mismatch in elderly patients with pulmonary hypertension: A nationwide multicenter study from Taiwan Society of Cardiology Pulmonary Hypertension Registry (TAIPANS).
Heliyon
March 2024
Background: Demographics of pulmonary hypertension (PH) has changed a lot over the past forty years. Several recent registries noted an increase in mean age of PH but only a few of them investigated the characteristics of elderly patients. Thus, we aimed to analyze the characteristics of PH in such a population in this study.
View Article and Find Full Text PDFBackground: Obstructive sleep apnea (OSA) is a risk factor for atrial fibrillation (AF); however, it is unclear whether AF increases the risk of OSA. Furthermore, sex differences among patients with both AF and OSA remain unclear. We aimed to determine the association between an increased AF burden and OSA and investigate the differences in clinical characteristics between women and men with AF and OSA.
View Article and Find Full Text PDFObjective: We aimed to investigate whether 2-[F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (2-[F]FDG PET/CT) can aid in evaluating the risk of malignancy in ampullary tumors detected by endoscopy.
Materials And Methods: This single-center retrospective cohort study analyzed 155 patients (79 male, 76 female; mean age, 65.7 ± 12.
Background: The 2022 AHA/ACC/HFSA guidelines for the management of heart failure (HF) makes therapeutic recommendations based on HF status. We investigated whether the prognosis of in-hospital cardiac arrest (IHCA) could be stratified by HF stage and left ventricular ejection fraction (LVEF).
Methods: This single-center retrospective study analyzed the data of patients who experienced IHCA between 2005 and 2020.