Publications by authors named "Yen-Pei Lu"
Glyphosate (GLY) is a widely used herbicide worldwide, particularly in cultivating genetically modified soybeans resistant to GLY. However, routine multi-residue analysis does not include GLY due to the complexity of soybean matrix components that can interfere with the analysis. This study presented the development of an aptamer-based chemiluminescence (Apt-CL) sensor for rapidly screening GLY pesticide residue in soybeans.
View Article and Find Full Text PDFNonalcoholic fatty liver disease is caused by an imbalance in lipid metabolism and immune response to pose a risk factor for liver fibrosis. Recent evidence indicates that M2 macrophages secrete transforming growth factor-β1, which contributes to liver fibrosis. Galectin-12 has been demonstrated to regulate lipid metabolism and macrophage polarization.
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- The increasing cases of diabetes due to an aging population strain healthcare systems and create public health issues, prompting the need for better monitoring methods.
- A new nano-sensing probe that uses only saliva for measuring blood sugar levels shows promise, as it is less invasive and more stable than traditional blood tests.
- The study found a significant correlation between salivary conductivity and diabetes risk, suggesting that this portable device could serve as an effective screening tool for early diabetes detection.
The use of poly-(para-chloro-xylylene) (Parylene C) in microelectromechanical systems and medical devices has increased rapidly. However, little research has been conducted on the wettability and surface roughness of Parylene C after being soaked in solutions. In this study, the contact angle and surface roughness (arithmetic average of roughness) of Parylene C on three-dimensional (3D)-printed photopolymer in 10% sodium hydroxide, 10% ammonium hydroxide, and 100% phosphate-buffered saline (PBS) solutions were investigated using a commercial contact angle measurement system and laser confocal microscope, respectively.
View Article and Find Full Text PDFBisphenol A (BPA) is an endocrine-disrupting chemical that affects lipid metabolism and contributes to non-alcoholic fatty liver disease (NAFLD). The mechanism of BPA exposure in hepatic lipid accumulation and its potential effect on NAFLD remain unclear. This study investigated the effect of BPA-exposure-induced hepatic lipid deposition on the pathology of NAFLD and its underlying mechanism in vitro and in vivo.
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- The prevalence of chronic kidney disease (CKD) is on the rise, causing significant healthcare challenges, primarily due to reliance on invasive blood tests that hinder early detection and awareness.
- Researchers developed a portable device to measure salivary conductivity using just 50 μL of saliva, finding that CKD patients had notably higher salivary conductivity levels.
- A study involving 214 adult participants indicates that elevated salivary conductivity is positively linked to age and fasting glucose but inversely related to kidney function; this suggests that salivary conductivity could be an effective non-invasive marker for early CKD screening.
Article Synopsis
- The study focused on creating a portable device to measure salivary conductivity as a non-invasive method for assessing fluid status in adults.
- It involved 20 volunteers who underwent a 13-hour observation period that included 12 hours of water restriction followed by rapid rehydration.
- Results showed that salivary conductivity increased during dehydration and decreased upon rehydration, correlating well with other fluid status indicators, suggesting the device can effectively screen for dehydration in healthy adults.
Chronic kidney disease (CKD) has become a major issue in long-term healthcare. It is caused by recurrent kidney injury, which is possible induced by dehydration and heat stress. Therefore, it is important to access the dehydration diagnosis on fields.
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- * Researchers tested chlorin e6 (Ce6) in both free and micelle forms to observe their effects during photodynamic therapy (PDT) on melanoma tumor-associated vasculature in mice.
- * Results showed that micelle-encapsulated Ce6 provided clearer vascular imaging and more effective vascular destruction compared to free Ce6, indicating its potential as a multifunctional agent in cancer therapy.
Biomimetic materials are used for creating microsystems to control cell growth spatially and elicit specific cellular responses by combining complex biomolecules with nanostructured surfaces. Intercellular cell-to-cell and cell-to-extracellular matrix (ECM) interactions in biomimetic materials have demonstrated potential in the development of drug discovery platforms and regeneration medicine. In this study, we developed a biomimetic nanostructured matrix by using various ECM molecular layers to create a biomimetic and biocompatible environment for realizing neuronal guidance in neural regeneration medicine.
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