Genital basal cell carcinoma, a different pathogenesis from sun-exposed basal cell carcinoma? A case-control study of 30 cases.

Background: Genital basal cell carcinoma (BCC) accounts for <1% of all BCCs. We aimed to elucidate the pathogenesis of genital BCC.

Methods: We retrospectively evaluated cases of pathologically diagnosed genital BCC between 1990 and 2016 in an Asian tertiary referral center.

The pathological spectrum and clinical correlation of pigmented purpuric dermatosis-A retrospective review of 107 cases.

Background: Various pathological findings have been reported in pigmented purpuric dermatosis, but their clinical significance remains unclear.

Methods: We retrospectively reviewed demographics, clinical presentations, pathological patterns and concurrent systemic diseases among biopsy-confirmed cases of pigmented purpuric dermatosis.

Results: A total of 107 cases were ascertained.

Tranilast Blocks the Interaction between the Protein S100A11 and Receptor for Advanced Glycation End Products (RAGE) V Domain and Inhibits Cell Proliferation.

The human S100 calcium-binding protein A11 (S100A11) is a member of the S100 protein family. Once S100A11 proteins bind to calcium ions at EF-hand motifs, S100A11 changes its conformation, promoting interaction with target proteins. The receptor for advanced glycation end products (RAGE) consists of three extracellular domains, including the V domain, C1 domain, and C2 domain.

Kinetic and thermodynamic analysis of Candida antarctica lipase B-catalyzed alcoholytic resolution of (R,S)-β-butyrolactone in organic solvents.

Optically pure (R)-β-butyrolactone as an important chiral building block in the syntheses of various biologically active compounds and biodegradable polymers was prepared from (R,S)-β-butyrolactone through kinetic resolution. Candida antarctica lipase B (CALB) with a high enantiomeric ratio of 198 enantioselectively catalyzed the ring opening of the racemate with methanol in methyl tert-butyl ether at 45 °C and yielded the remaining (R)-β-butyrolactone. A detailed kinetic analysis indicated that methanol and (R)- and (S)-methyl ester all acted as competitive inhibitors for the enzyme.