Design and evaluation of oral formulation for apixaban.

Non-valvular atrial fibrillation (NVAF) is a common form of cardiac arrhythmia that affects 1-1.5% of adults and roughly 10% of elderly adults with dysphagia. Apixaban is an anticoagulant referred to as a factor Xa inhibitor, which has been shown to reduce the risk of stroke and systemic embolism in cases of NVAF.

Upregulation of miR-210-5p impairs dead cell clearance by macrophages through the inhibition of Sp1-and HSCARG-dependent NADPH oxidase pathway.

The deficiency of dead cell clearance is a prominent pathogenic factor in systemic lupus erythematosus (SLE). In this study, the overexpression of miR-210-5p resulted in the accumulation of secondary necrotic cells (SNECs) in macrophages through the reduction of protein degradation. The upreguation of miR-210-5p inhibited NADPH oxidase (NOX) activation, reactive oxygen species (ROS) generation, and SNEC clearance.

Aged Citrus Peel (Chenpi) Prevents Acetaminophen-Induced Hepatotoxicity by Epigenetically Regulating Nrf2 Pathway.

Excessive consumption of analgesic drug acetaminophen (APAP) can cause severe oxidative stress-mediated liver injury. Here, we investigated the protective effect and mechanism of aged citrus peel (Chenpi, CP), a Chinese herb usually used in foods in Asia, against APAP-induced hepatotoxicity. CP water (CP-WE), ethanolic (CP-EE), and water extraction residue ethanolic (CP-WREE) extracts were prepared.

Complete mitogenomes of Cocos lemonpeel angelfish (Centropyge flavissima) and Eibl's angelfish (Centropyge eibli) (Teleostei: Pomacanthidae).

In this study, we used the next-generation sequencing method to deduce two complete mitogenomes of Cocos lemonpeel angelfish (Centropyge flavissima) and Eibl's angelfish (Centropyge eibli) for the first time. The assembled mitogenome, consisting of 17 010 bp and 17 101 bp, showing 98.3% identity each other.

Complete mitogenomes of Spotbreast angelfish (Genicanthus melanospilos) and Blackstriped angelfish (Genicanthus lamarck) (Teleostei: Pomacanthidae).

In this study, we used the next-generation sequencing method to deduce two complete mitogenomes of Spotbreast angelfish (Genicanthus melanospilos) and Blackstriped angelfish (Genicanthus lamarck) for the first time. The assembled mitogenome, consisting of 16 736 bp and 16 616 bp, showing 91.8% identity each other.

Complete mitogenomes of Whitetail angelfish (Centropyge flavicauda) and Orangeback angelfish (Centropyge acanthops) (Teleostei: Pomacanthidae).

Whitetail Angelfish (Centropyge flavicauda) and Orangeback Angelfish (Centropyge acanthops) are known as pygmy angelfish due to their small body size (usually less than two inches). In this study, we used the next-generation sequencing method to deduce two complete mitogenomes of C. flavicauda and C.

Complete mitogenomes of Barred angelfish (Paracentropyge multifasciata) and Purplemask angelfish (Paracentropyge venusta) (Teleostei: Pomacanthidae).

In this study, we used the next-generation sequencing method to deduce two complete mitogenomes of Barred angelfish (Paracentropyge multifasciata) and Purplemask angelfish (Paracentropyge venusta) for the first time. The assembled mitogenome, consisting of 16 502 bp and 16 641 bp, showing 88.6% identity each other.

Next generation sequencing yields complete mitogenomes of Leopard whipray (Himantura leoparda) and Blue-spotted stingray (Neotrygon kuhlii) (Chondrichthyes: Dasyatidae).

The Leopard whipray (Himantura leoparda) and Blue-spotted stingray (Neotrygon kuhlii) are distributed in the Indian and West Pacific Ocean and considered as complex species based on morphological and molecular evidences. In this study, we used the next-generation sequencing method to decode two complete mitogenomes of H. leoparda and N.