A Single-Chip High-Voltage Integrated Actuator for Biomedical Ultrasound Scanners.

This article presents a high-voltage (HV) pulse driver based on silicon-on-insulator (SOI) technology for biomedical ultrasound actuators and multi-channel portable imaging systems specifically. The pulse driver, which receives an external low-voltage drive signal and produces high-voltage pulses with a balanced rising and falling edge, is designed by synthesizing high-speed, capacitor-coupled level-shifters with a high-voltage H-bridge output stage. In addition, an on-chip floating power supply has also been developed to simplify powering the entire system and reduce static power consumption.

Half-sandwich Ru(η-p-cymene) complexes featuring pyrazole appended ligands: Synthesis, DNA binding and in vitro cytotoxicity.

Organometallic Ru(II)-arene complexes have emerged as potential alternatives to platinum appended agents due to their wide range of interesting features such as stability in solution and solid, significant activity, less toxicity and hydrophobic property of arene moiety, etc. Hence, a series of Ru(II)-p-cymene complexes, [(η-p-cymene)Ru(η-N,N-L1)Cl]Cl (1), [(η-p-cymene)Ru(η-N-L2)Cl] (2) and [(η-p-cymene)Ru(η-N-L3)Cl] (3) were prepared from pyrazole based ligands [2-(1H-pyrazol-3-yl)pyridine (L1), 3-(furan-2-yl)-1H-pyrazole (L2) and 3-(thiophen-2-yl)-1H-pyrazole (L3)], and [RuCl-(η-p-cymene)] dimer. The new Ru(II)-p-cymene complexes were well characterized by elemental analysis, and spectroscopic (FT-IR, UV-Visible, H NMR, C NMR and mass) and crystallographic methods.