Publications by authors named "Yen-Chieh Chang"
Article Synopsis
- - The study aimed to identify OCT-based biomarkers that can help predict treatment response in diabetic macular edema (DME) patients receiving intravitreal ranibizumab injections, which is crucial for customizing treatment plans.
- - Researchers analyzed data from 65 eyes of 35 patients, tracking visual acuity, central retinal thickness, and other OCT features at various time points before and after treatment.
- - Results showed that specific biomarkers like DRIL, LONLC, and SRF were significant predictors of visual and structural improvements, demonstrating the potential value of OCT biomarkers in managing DME.
Purpose: To identify optical coherence tomography (OCT) biomarkers that may predict functional and anatomical outcomes in diabetic macular edema (DME) patients treated with intravitreal dexamethasone (DEX) implant.
Materials And Methods: Sixty-four eyes from 50 patients with DME were enrolled. Best-corrected visual acuity (BCVA) and OCT biomarkers including central retinal thickness (CRT), subretinal fluid (SRF), intraretinal cysts (IRC), ellipsoid zone disruption (EZD), disorganization of retinal inner layers (DRIL), hard exudate (HE), hyperreflective foci (HRF), epiretinal membrane (ERM), and vitreomacular interface (VMI) changes were evaluated at baseline and at 3, 6, and 12 months after treatment.