Purpose: To investigate the effect of chronic cigarette smoking on the endothelial cells of the cornea via non-contact specular microscopy.
Method: In this prospective, cross-sectional study, 25 eyes of 25 chronic smokers and 21 eyes of 21 age-matched, healthy non-smokers were enrolled. The Fagerström Test for Nicotine Dependence on Cigarettes was used to determine the nicotine dependency level.