EF2-kinase targeted cobalt-ferrite siRNA-nanotherapy suppresses -mutated breast cancer.

To investigate the role of EF2K in -mutated breast cancer. We developed silica coated cobalt-ferrite (CoFe) nanoparticles for  delivery of small interfering RNAs (siRNAs) into -mutated breast cancer. Expression of EF2K is highly upregulated in the majority (78.

Cellular uptake, genotoxicity and cytotoxicity of cobalt ferrite magnetic nanoparticles in human breast cells.

Magnetic nanoparticles (MNPs) have been increasingly used for many years as MRI agents and for gene delivery and hyperthermia therapy, although there have been conflicting results on their safety. In this study, cobalt ferrite magnetic nanoparticles (CoFe-MNPs) were prepared by the co-precipitation method and their surfaces were modified with silica by the sol-gel method. The particle and hydrodynamic sizes, morphology and crystal structure of the bare and silica-coated CoFe-MNPs were evaluated by transmission electron microscopy (TEM), dynamic light scattering (DLS), X-ray diffraction spectroscopy (XRD) and Fourier transform infrared spectroscopy (FTIR).

A Novel Acetylcholinesterase Biosensor: Core-Shell Magnetic Nanoparticles Incorporating a Conjugated Polymer for the Detection of Organophosphorus Pesticides.

To construct a sensing interface, in the present work, a conjugated polymer and core-shell magnetic nanoparticle containing biosensor was constructed for the pesticide analysis. The monomer 4,7-di(furan-2-yl)benzo[c][1,2,5]thiadiazole (FBThF) and core-shell magnetic nanoparticles were designed and synthesized for fabrication of the biosensing device. The magnetic nanoparticles were first treated with silica and then modified using carboxyl groups, which enabled binding of the biomolecules covalently.

Knowledge and attitudes of nurses regarding patient rights: a Corum/Turkey sample.

Objective: patient rights are defined as the rules of conduct between the people who benefit from health services and the health institutions and personnel who provide them. As the protection and provision of these rights are closely related to the nursing trade, these professionals must have thorough knowledge about this issue. The purpose of this study was to evaluate the acquaintance and attitudes of working nurses in Corum/Turkey regarding patient rights and to create the basis for a planned educational program.

The effects of pre-op trainning on the anxiety levels of children in Corum/Turkey.

Objective: all individuals regardless of their age or level of development require physical, emotional and cognitive preparation before an operation. It is known that the attitudes of pediatric nurses towards pediatric patients are influential on the anxiety levels of children awaiting an operation. This study aims to determine the effect of pre-op trainning on the anxiety levels of pediatric patients hospitalized for hernioplasty surgery.

Knowledge, attitude about breast cancer and practice of breast cancer screening among female health care professionals: a study from Turkey.

The awareness of health professionals about breast cancer prevention is of vital importance, since their beliefs and behaviors may have a major impact on other women. The aim of this study was to investigate the knowledge, and attitudes regarding risk factors for breast cancer as well as screening such as breast self-examination, clinical breast examination and mammography among different groups of female health professionals. In this cross- sectional study, 444 female health professionals in various health centers located in Corum Province, Turkey, were interviewed using a self-administered questionnaire.