Publications by authors named "Yelena Britan-Rosich"
Influenza represents one of the biggest health threats facing humanity. Seasonal epidemics can transition to global pandemics, with cross-species infection presenting a continuous challenge. Although vaccines and several anti-viral options are available, constant genetic drifts and shifts vitiate any of the aforementioned prevention and treatment options.
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- AID/APOBEC proteins, including APOBEC3G (A3G), are vital nucleic acid editors that play significant roles in immune response but can also trigger mutations that lead to cancer.
- The study shows that A3G helps repair double-strand breaks in DNA, helping transgenic mice survive lethal doses of radiation while wild-type mice do not.
- Research indicates that inhibiting A3G could improve cancer treatment effectiveness, while boosting its activity might alleviate symptoms from acute radiation exposure.
Selecting for antibodies against specific cell-surface proteins is a difficult task due to many unrelated proteins that are expressed on the cell surface. Here, we describe a method to screen antibody-presenting phage libraries against native cell-surface proteins. We applied this method to isolate antibodies that selectively recognize CCR5, which is the major co-receptor for HIV entry (consequently, playing a pivotal role in HIV transmission and pathogenesis).
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