Publications by authors named "Yele Ladipo"
Article Synopsis
- Cerebral malaria (CM) is a severe and deadly form of malaria affecting children in Africa, with mechanisms of neuroinflammation and patient outcomes still not fully understood.* -
- The study involved 70 children with CM in southern Benin, assessing various clinical and biochemical markers to determine the factors influencing survival versus death.* -
- Key findings indicated that children who died from CM had elevated plasma levels of inflammatory markers like TNF and IL-1β, as well as decreased levels of urinary PGEM, suggesting these biomarkers could help predict mortality risk in CM patients.*
Monocytes are plastic heterogeneous immune cells involved in host-parasite interactions critical for malaria pathogenesis. Human monocytes have been subdivided into three populations based on surface expression of CD14 and CD16. We hypothesised that proportions and phenotypes of circulating monocyte subsets can be markers of severity or fatality in children with malaria.
View Article and Find Full Text PDFPlasmodium falciparum is responsible of severe malaria, including cerebral malaria (CM). During its intra-erythrocytic maturation, parasite-derived proteins are expressed, exported and presented at the infected erythrocyte membrane. To identify new CM-specific parasite membrane proteins, we conducted a mass spectrometry-based proteomic study and compared the protein expression profiles between 9 CM and 10 uncomplicated malaria (UM) samples.
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