A novel approach to CSF pressure measurement via lumbar puncture that shortens the measurement time with a high level of accuracy.

Intracranial pressure (ICP) is an important parameter in clinical management and diagnosis of several neurological diseases which is indirectly measured via lumbar puncture (LP). In routine measurements of cerebrospinal fluid pressure (P) from lumbar region, a spinal needle and a spinal manometer are used. P measurement via LP with the use of a spinal manometer may not yield correct P results due to prolonged times required to obtain an accurate pressure value.

The complex impedance phase angle of dominant arm: a useful parameter in bone mineral density (BMD) assessment of group 1 post-menopausal women.

For widespread osteoporosis (OP) screening, portable and cost-effective screening devices are needed. With 45 menopaused women, when body mass index was below 30 kg.m, the phase angle (PhA) of complex bioimpedance at 5 kHz, measured from the dominant arm, was correlated with dual-energy X-ray absorptiometry (DEXA) measured central bone mineral densities (BMD), for total hip r = 0.

Characterization of carotid endothelial cell proliferation on Au, Au/GO, and Au/rGO surfaces by electrical impedance spectroscopy.

To the best of the authors' knowledge, testing the biocompatibility of graphene coatings can be considered as the first to demonstrate human carotid endothelial cell (HCtAEC) proliferation on Au, graphene oxide-coated Au (Au/GO), and reduced graphene oxide-coated Au (Au/rGO) surfaces. We hypothesized that stent material modified with graphene (G)-based coatings could be used as electrodes for electrical impedance spectroscopy (EIS) in monitoring cell cultures, i.e.

2D-ROC: a receiver operating surface and its illustrative application in clinical diagnostics.

Objective: When there are multiple tests, the receiver operating characteristic (ROC) curve analysis does not answer the question of how the individual tests can be combined in medicine.

Approach: In this study, 2D-ROC analysis is considered to calculate the correct classification rate (CCR) by using two independent test results. To obtain the best combination of paired tests, results were combined as 'BOTH', 'ANY' or 'AVERAGE' for the final 2D-ROC decision.

Estimation of free hemoglobin concentrations in blood bags by diffuse reflectance spectroscopy.

Free hemoglobin (FHB) concentration is considered a prospect quality indicator for erythrocyte suspensions (ES) under storage. Storage lesions alter the optical properties of ES and can be monitored by diffuse reflectance spectroscopy. Due to storage lesions, erythrocytes lyse and release hemoglobin into the extracellular medium.

Screening Post-menopausal Women for Bone Mineral Level by Bioelectrical Impedance Spectroscopy of Dominant Arm.

Dominant arm bioimpedance spectroscopy (BIS) and lumbar and hip dual energy X-ray absorptiometry (DXA) measurements were conducted simultaneously on 48 post-menopausal women, aged between 43 and 86 years, with no hip or arm fracture history at Department of Radiology of Istanbul University Cerrahpasa Hospital. According to lumbar DXA results, 21 women were classified as normal, 22 as osteopenia and 5 as osteoporosis; whereas hip DXA results classified 30 women as normal, 15 as osteopenia and 3 as osteoporosis. Only 26 participants had identical lumbar and hip bone mineral density (BMD) diagnostic results.

Photobiomodulation of wound healing via visible and infrared laser irradiation.

Fibroblast cells are known to be one of the key elements in wound healing process, which has been under the scope of research for decades. However, the exact mechanism of photobiomodulation on wound healing is not fully understood yet. Photobiomodulation of 635 and 809 nm laser irradiation at two different energy densities were investigated with two independent experiments; first, in vitro cell proliferation and then in vivo wound healing.

Laser biostimulation of wound healing: bioimpedance measurements support histology.

Laser biostimulation in medicine has become widespread supporting the idea of therapeutic effects of photobiomodulation in biological tissues. The aim of this study was to investigate the biostimulation effect of laser irradiation on healing of cutaneous skin wounds, in vivo, by means of bioimpedance measurements and histological examinations. Cutaneous skin wounds on rats were subjected to 635 nm diode laser irradiations at two energy densities of 1 and 3 J/cm separately.

Using a low-amplitude RF pulse at echo time (LARFET) for device localization in MRI.

We describe a new method for frequency down-conversion of MR signals acquired with the radio-frequency projections method for device localization. A low-amplitude, off-center RF pulse applied simultaneously with the echo signal is utilized as the reference for frequency down-conversion. Because of the low-amplitude and large offset from the Larmor frequency, the RF pulse minimally interfered with magnetic resonance of protons.

Network security vulnerabilities and personal privacy issues in Healthcare Information Systems: a case study in a private hospital in Turkey.

Healthcare industry has become widely dependent on information technology and internet as it moves from paper to electronic records. Healthcare Information System has to provide a high quality service to patients and a productive knowledge share between healthcare staff by means of patient data. With the internet being commonly used across hospitals, healthcare industry got its own share from cyber threats like other industries in the world.

Classification of juvenile myoclonic epilepsy data acquired through scanning electromyography with machine learning algorithms.

In this paper, classification of Juvenile Myoclonic Epilepsy (JME) patients and healthy volunteers included into Normal Control (NC) groups was established using Feed-Forward Neural Networks (NN), Support Vector Machines (SVM), Decision Trees (DT), and Naïve Bayes (NB) methods by utilizing the data obtained through the scanning EMG method used in a clinical study. An experimental setup was built for this purpose. 105 motor units were measured.

Large motor unit territories by scanning electromyography in patients with juvenile myoclonic epilepsy.

Juvenile myoclonic epilepsy is a genetically inherited disorder characterized by myoclonic jerks and generalized seizures. It has been proposed that patients with juvenile myoclonic epilepsy have larger motor units (MUs) than normals by MU number estimation and macro electromyography techniques. In this study, an experimental setup for scanning electromyography was built to investigate electrophysiologic cross-sections of the MU territories in 9 patients with juvenile myoclonic epilepsy, 3 patients with spinal muscular atrophy, and 10 healthy volunteers.

Effects of physiological parameters on the electrical properties of blood bank stored erythrocyte suspensions.

In this study, the physiological parameters such as extracellular (SAGM+CPD+residual plasma) Na+, K+, Cl-, pH, 2,3-DPG and ATP together with the Cole-Cole parameters were measured using erythrocyte suspensions from 51 male donors (31 donors form the training set and 20 donors are used for testing), on the 0th, 10th, 21st, 35th and 42nd days of storage. Accordingly, electrical parameters were all correlated with Na+, K+, Cl-, pH and ATP, at varying levels. By applying the multi-regression analysis, it is concluded that Ri, Re and Cm are appropriate for modeling Na+, K+, Cl-, pH and ATP during blood bank storage and predicting blood quality.

Gamma Knife 3-D dose distribution near the area of tissue inhomogeneities by normoxic gel dosimetry.

The accuracy of the Leksell GammaPlan, the dose planning system of the Gamma Knife Model-B, was evaluated near tissue inhomogeneities, using the gel dosimetry method. The lack of electronic equilibrium around the small-diameter gamma beams can cause dose calculation errors in the neighborhood of an air-tissue interface. An experiment was designed to investigate the effects of inhomogeneity near the paranosal sinuses cavities.

Relative dose distribution in gamma knife treatment near tissue inhomogeneties.

The primary goal in this study was to investigate 3-D dose distribution, near the areas of tissue inhomogeneities, in Gamma Knife Radiosurgery with the gel dosimetry. The spherical glass balloon of a diameter of 16 cm filled with the gel forms the homogeneous phantom; and an identical balloon with two corks placed on each side to represent the air cavities forms the inhomogeneous phantom. Dose calibration is performed by irradiating vials at known doses and then utilizing the R2- dose calibration curve.

Changes in electrical and physiological properties of human blood during storage.

In this study, the relationship between physiological parameters and electrical impedance changes of human blood and their further clinical implications are investigated. The study is performed on 255 erythrocyte suspension samples derived from 51 male donors. The samples are stored at 4°C and measurements are done on the 0, 10, 21, 35and 42days of storage.