Nationwide Trends in Screen Time and Associated Risk Factors by Family Structures Among Adolescents, 2008-2022: Nationwide Cross-Sectional Study.

Background: Although understanding long-term trends in adolescent screen time and the influence of family structure is essential, there is a lack of research addressing these issues comprehensively.

Objective: This study aimed to conduct comprehensive investigations into adolescent screen time before and during the COVID-19 pandemic, with a particular focus on family structures.

Methods: This study used nationwide, large-scale data from the Korea Youth Risk Behavior Web-Based Survey from South Korea.

Disproportionality analysis from World Health Organization data on migraine-specific medications and cerebrovascular diseases.

Background: Migraine is a major cause of population ill health, with an estimated global prevalence of approximately 14-15%. However, given the limited research on the associations between specific migraine medications and adverse cerebrovascular events, this study aimed to investigate these relationships and their impact on cerebrovascular risk.

Methods: This study utilized data from the global pharmacovigilance database, which covers 170 countries from 1968 to 2024.

Association between social engagement frequency and the risk of depression in South Korea, the US, and the UK: Multinational evidence from longitudinal studies of aging.

Background: While greater social engagement is often associated with a reduced risk of depression, longitudinal studies that account for diverse social structures and cultural contexts among middle-aged or older are limited.

Methods: This study utilized cohort data from the Korean Longitudinal Study of Ageing (n=11,174; 2006-2020) in South Korea (KR), the Health and Retirement Study (n=42,405; 2004-2019) in the US, and the English Longitudinal Study of Ageing (n=28,624; 2002-2019) in the UK, including a total of 29,378 individuals from the population aged ≥45 years. Social engagement frequency was categorized into infrequent, intermediate, and frequent, with changes classified as unchanged, increased, or decreased.

Dose-response association between physical activity and diagnosed hypertension in 2.4 million Korean population: Korea Community Health Survey 2009-2022.

Background: Hypertension, a significant risk factor for global public health, is well-known to be preventable and manageable through physical activity (PA). However, many studies suggest that excessive PA may not provide additional benefits. Thus, we aimed to conduct a quantitative analysis of the relationship between hypertension and PA levels.

Development and Validation of a Machine Learning Algorithm for Predicting Diabetes Retinopathy in Patients With Type 2 Diabetes: Algorithm Development Study.

Background: Diabetic retinopathy (DR) is the leading cause of preventable blindness worldwide. Machine learning (ML) systems can enhance DR in community-based screening. However, predictive power models for usability and performance are still being determined.

Long-term trends in the prevalence of cardiovascular-kidney-metabolic syndrome in South Korea, 2011-2021: a representative longitudinal serial study.

Background: The American Heart Association recently introduced a new framework, known as cardiovascular-kidney-metabolic (CKM) syndrome, aimed at the early prevention of cardiovascular disease. However, this syndrome has not been studied extensively outside of the United States. Thus, this study aimed to examine the long-term trends in CKM syndrome and its associated demographic features in South Korea.

Long-term trends and patterns in ultra-processed food consumption among Korean adults from 1998 to 2022.

Ultra-processed foods are linked to adverse health outcomes, making it crucial to monitor consumption trends. Despite rising consumption due to Westernized diets in Asia, long-term studies targeting Asian adults are lacking. Thus, we analyzed ultra-processed food consumption trends among Korean adults from 1998 to 2022.

Prediction model for type 2 diabetes mellitus and its association with mortality using machine learning in three independent cohorts from South Korea, Japan, and the UK: a model development and validation study.

Background: Type 2 diabetes mellitus (T2DM) is a significant global public health concern that has steadily increased over the past few decades. Thus, this study aimed to predict the incidence of T2DM within 5 years and the risk of mortality following the onset of T2DM. Data from three independent cohorts worldwide were used.

Temporal trends and patterns in mortality from falls across 59 high-income and upper-middle-income countries, 1990-2021, with projections up to 2040: a global time-series analysis and modelling study.

Background: Deaths related to falls are a substantial public health problem worldwide, and insight into trends and differences in global fall-related deaths can be valuable for identifying prevention strategies and developing effective policies. Thus, we aimed to estimate global fall-related mortality rate trends and forecast future fall-related deaths.

Methods: In this global time-series analysis and modelling study, we investigated temporal trends in fall-related mortality rates from 1990 to 2021 using the WHO Mortality Database, following the GATHER guidelines, and forecasted trends until 2040 across 59 high-income and upper-middle-income countries.

Use of Biologics to Treat Asthma during Pregnancy and Adverse Events in Pregnant Women and Newborns: A Global Pharmacovigilance Analysis.

Introduction: Despite the increasing evidence supporting the use of biologics for treating severe asthma, there is a lack of evidence regarding their use in pregnant women. This study aims to evaluate the safety of biologics for pregnant women, utilizing global pharmacovigilance database.

Methods: Reports documented between 1980 and 2023 were extracted from the VigiBase that mentioned pregnancy- or fetus-related reactions with drugs indicated for asthma, including reslizumab, omalizumab, mepolizumab, dupilumab, benralizumab, and other non-biologics.

Association between behavioral and sociodemographic factors and high subjective health among adolescents: a nationwide representative study in South Korea.

The need to understand subjective health has increased during the COVID-19 pandemic, given its substantial impact on lifestyle habits and perceptions. Thus, this study aimed to investigate the trends and association of subjective health with demographic and behavioral factors, primarily focusing on the change when the COVID-19 pandemic emerged. This study used data from the Korea Youth Risk Behavior Web-based Survey, comprising 1,190,468 adolescents aged 12-18 years (female, 48.

Associations between weight-control methods and depression among Korean adolescents: a study based on a national dataset.

Background/objectives: The increasing prevalence of overweight and obesity has become a significant global burden, with more than 40% of the global adult population attempting to lose weight. Previous studies on the impact of weight-control methods on mental health, especially among adolescents, are limited. Thus, this study aimed to investigate the association between various weight-control methods and depression among adolescents, with the goal of informing healthier weight management decisions and promoting effective methods.

Racial Discrimination and Multiple Health Outcomes: An Umbrella Review of Systematic Reviews and Meta-Analyses.

Objective: We aimed to systematically investigate the associations between racial discrimination and various health outcomes and to evaluate the certainty of evidence from existing meta-analyses of observational studies.

Method: We systemically searched the associations between racial discrimination and health outcomes for PubMed/MEDLINE, Embase, WoS, and Google Scholar up until January 31, 2024. Notably, the included studies were predominantly conducted in the USA and Europe, limiting the generalizability of our findings to a global context.

Global, Regional, and National Trends in Liver Disease-Related Mortality Across 112 Countries From 1990 to 2021, With Projections to 2050: Comprehensive Analysis of the WHO Mortality Database.

Background: Liver disease causes over two million deaths annually worldwide, comprising approximately 4% of all global fatalities. We aimed to analyze liver disease-related mortality trends from 1990 to 2021 using the World Health Organization (WHO) Mortality Database and forecast global liver disease-related mortality rates up to 2050.

Methods: This study examined age-standardized liver disease-related death rates from 1990 to 2021, employing data from the WHO Mortality Database across 112 countries across five continents.

Global trends of secondhand smoke exposure among young adolescents from 27 countries, 2003-2021: findings from the World Health Organization database.

The issue of adolescent secondhand smoke (SHS) is globally significant, given that it serves as a preventable risk factor for disease prevalence and mortality rates among youth. This study evaluates trends in adolescent SHS across 27 countries from 2003 to 2021, aiming to identify global variations and sex-specific differences, providing insights for future policy recommendations. The data for this study were collected from the Global School-based Student Health Survey conducted by the World Health Organization, 2003-2021.

Comparison of national trends in physical activity among adolescents before and during the COVID-19 pandemic: A nationally representative serial study in South Korea.

Background: The COVID-19 pandemic has dramatically altered daily routines and lifestyle behaviors worldwide, potentially significantly impacting physical activity levels, especially among adolescents. Understanding these changes is crucial for developing targeted interventions to promote health and well-being in this vulnerable population. This paper will explore longitudinal trends of physical activities (PA) in Korean adolescents, focusing on changes between the pre and late-COVID-19 pandemic periods.

Global Incidence and Prevalence of Chronic Rhinosinusitis: A Systematic Review.

Objective: Data on the global prevalence of chronic rhinosinusitis (CRS) is significantly varied and limited across countries and over time. Therefore, we aimed to conduct a comprehensive investigation into the global, regional, and national burden of CRS from the years 1980 to 2021, as well as identify those factors that influence levels of such burden.

Design: We conducted a systematic review and meta-analysis of general population-based observational studies focusing on CRS.

National trends in thyroid disease and COVID-19 pandemic-related factors, 1998-2021: A nationwide representative study in South Korea.

Objective: Although thyroid disease is a common condition, there is limited research examining the prevalence of thyroid disease over a long period of time, including both before and during the COVID-19 pandemic. Therefore, we aimed to investigate sociodemographic aspects that might be associated with thyroid disease and how its prevalence has varied during the pandemic.

Methods: We assessed the prevalence of thyroid disease among Korean adults by using data from the Korea National Health and Nutrition Examination Survey from 1998 to 2021.

Reply to the Comments on "Biomarkers and Related Factors for the Diagnosis, Risk of Coronary Artery Lesions, and Resistance to Intravenous Immunoglobulin in Kawasaki Disease: An Umbrella Review of Meta-Analyses".

The article "Biomarkers and related factors for the diagnosis, risk of coronary artery lesions, and resistance to intravenous immunoglobulin in Kawasaki disease: an umbrella review of meta-analyses" offers valuable insights into diagnostic and therapeutic settings by overviewing various biomarkers associated with Kawasaki disease. There are some comments related to our umbrella review methodology, particularly PRIOR guidelines and GRADE framework. We clarify our choice of the PRISMA 2020 guidelines over PRIOR and explain the rigorous methodology used, which aligns with GRADE principles, ensuring robust and reliable findings.

National trends in type 2 diabetes mellitus stratified by central adiposity using waist-to-height ratio in South Korea, 2005-2022.

Studies investigating the association between type 2 diabetes mellitus and central adiposity are lacking. Therefore, this study aimed to investigate trends in type 2 diabetes mellitus stratified by central adiposity using waist-to-height ratio (WHtR). Trends in type 2 diabetes mellitus were examined by central adiposity, using WHtR, with data from the Korea National Health and Nutrition Examination Survey (2005-2022).