Publications by authors named "Yejing Rong"
Article Synopsis
- * The study introduces a new oncolytic adenovirus called rAd.mDCN.mCD40L, which shows strong anti-cancer effects in both human and mouse CRC cells by using specific promoter technology and expressing mouse genes involved in immune response.
- * In experiments with a mouse tumor model, rAd.mDCN.mCD40L not only inhibited tumor growth and liver metastasis but also positively impacted the immune environment, increasing anti-tumor immune cells while reducing immunosuppressive cells, suggesting it could be a valuable CRC
We developed a rapid and simple magnetic chemiluminescence enzyme immunoassay on the Real Express-6 analyzer, which could simultaneously detect immunoglobulin G and immunoglobulin M antibodies against SARS-CoV-2 virus in human blood within 18 min, and which could be used to detect clinical studies to verify its clinical efficacy. We selected blood samples from 185 COVID-19 patients confirmed by polymerase chain reaction and 271 negative patients to determine the clinical detection sensitivity, specificity, stability, and precision of this method. Meanwhile, we also surveyed the dynamic variance of viral antibodies during SARS-CoV-2 infection.
View Article and Find Full Text PDFFibre is the viral protein that mediates the attachment and infection of adenovirus to the host cell. Fowl adenovirus 4 (FAdV-4) possesses two different fibre trimers on each penton capsomere, and roles of the separate fibres remain elusive. Here, we attempted to investigate the function of FAdV-4 fibres by using reverse genetics approaches.
View Article and Find Full Text PDFArticle Synopsis
- * It was found that these isoforms play different roles in macrophage polarization, with CXCR3.1 linked to an M1 phenotype (pro-inflammatory) and CXCR3.2 associated with an M2 phenotype (anti-inflammatory) in species like ayu and grass carp.
- * The research indicates that specific proteins and transcription factors are involved in this polarization process, and improved outcomes were observed in septic ayu with PaCXCR3.2 macrophages, highlighting the importance of these genes in immune responses.
Haematopoietic stem cells (HSCs) can differentiate into cells of all lineages in the blood. However, the mechanisms by which cytokines in the blood affect HSC homeostasis remain largely unknown. Here we show that leukocyte cell-derived chemotaxin 2 (LECT2), a multifunctional cytokine, induces HSC expansion and mobilization.
View Article and Find Full Text PDFHaematopoietic stem/progenitor cells (HSPCs) can mobilise into blood and produce immune cell lineages following stress. However, the homeostasis and function of HSPCs after infection in teleosts are less well known. Here, we report that Listonella anguillarum infection enhances HSPC mobilisation and reduces their differentiation into myeloid cells in ayu (Plecoglossus altivelis), an aquacultured teleost in East Asia.
View Article and Find Full Text PDFArticle Synopsis
- Prostaglandin E2 (PGE2) interacts with E-type prostanoid receptors, specifically EP4, which is important for immune responses, but its role in fish remains unclear.
- The study characterized a novel EP4-like gene (PaEP4L) in ayu fish, establishing that this gene shares 76% amino acid identity with its counterpart in Atlantic salmon and is expressed in various tissues, especially during Vibrio anguillarum infections.
- Additionally, the research showed that PaEP4L mediates the effects of PGE2 on immune cell functions in ayu fish, influencing immune responses like cytokine expression and phagocytosis.