NR1D1-transactivated lncRNA NUTM2A-AS1 promotes chemoresistance and immune evasion in neuroblastoma via inhibiting B7-H3 degradation.

Neuroblastoma (NB), a common solid tumour in young children originating from the sympathetic nervous system during embryonic development, poses challenges despite therapeutic advances like high-dose chemotherapy and immunotherapy. Some survivors still grapple with severe side effects and drug resistance. The role of lncRNA NUTM2A-AS1 has been explored in various cancers, but its function in drug-resistant NB progression is unclear.

Interphase Engineering Enhanced Electro-chemical Stability of Prelithiated Anode.

Prelithiation is an essential technology to compensate for the initial lithium loss of lithium-ion batteries due to the formation of solid electrolyte interphase (SEI) and irreversible structure change. However, the prelithiated materials/electrodes become more reactive with air and electrolyte resulting in unwanted side reactions and contaminations, which makes it difficult for the practical application of prelithiation technology. To address this problem, herein, interphase engineering through a simple solution treatment after chemical prelithiation is proposed to protect the prelithiated electrode.

Temperature-dependent interphase formation and Li transport in lithium metal batteries.

High-performance Li-ion/metal batteries working at a low temperature (i.e., <-20 °C) are desired but hindered by the sluggish kinetics associated with Li transport and charge transfer.

Cryo-EM for battery materials and interfaces: Workflow, achievements, and perspectives.

The emerging cryogenic electron microscopy (cryo-EM) has demonstrated its power and essential role in probing the beam-sensitive battery materials and delivering new insights. With the increasing interest in cryo-EM for battery materials and interfaces, herein we provide the strategies of obtaining fresh and native structural information with minimal artifacts, including sample preparation, transferring, imaging, and data interpretation. We summarize the recent achievements enabled by cryo-EM and point out some unsolved/potential questions in terms of the bulk materials, solid-solid interface, and solid-liquid interfaces of batteries.

miR-100 Suppresses the Proliferation, Invasion, and Migration of Hepatocellular Carcinoma Cells via Targeting CXCR7.

This study is to elucidate the functions of miR-100 in hepatocellular carcinoma progression and to explore the underlying mechanisms. Expression levels of miR-100 in normal-cancer hepatocellular carcinoma tissues were measured using quantitative real-time PCR (qRT-PCR). The invasive and proliferative abilities of hepatocellular carcinoma cell lines transfected with mimic-NC or mimic-miR-100 were measured using transwell, CCK-8, and colony formation assays.

A disordered rock salt anode for fast-charging lithium-ion batteries.

Rechargeable lithium-ion batteries with high energy density that can be safely charged and discharged at high rates are desirable for electrified transportation and other applications. However, the sub-optimal intercalation potentials of current anodes result in a trade-off between energy density, power and safety. Here we report that disordered rock salt LiVO can be used as a fast-charging anode that can reversibly cycle two lithium ions at an average voltage of about 0.

Glassy Li metal anode for high-performance rechargeable Li batteries.

Lithium metal has been considered an ideal anode for high-energy rechargeable Li batteries, although its nucleation and growth process remains mysterious, especially at the nanoscale. Here, cryogenic transmission electron microscopy was used to reveal the evolving nanostructure of Li metal deposits at various transient states in the nucleation and growth process, in which a disorder-order phase transition was observed as a function of current density and deposition time. The atomic interaction over wide spatial and temporal scales was depicted by reactive molecular dynamics simulations to assist in understanding the kinetics.

Lithium Plating and Stripping on Carbon Nanotube Sponge.

Lithium metal is an ideal anode material due to its high specific capacity and low redox potential. However, issues such as dendritic growth and low Coulombic efficiency prevent its application in secondary lithium batteries. The use of three-dimensional (3D) porous current collector is an effective strategy to solve these problems.

Spectroscopic study on the interaction of bovine serum albumin with zinc(II) phthalocyanine.

The interaction between the photosensitive antitumour drug, 2(3),9(10),16(17),23(24)-tetra-(((2-aminoethylamino)methyl)phenoxy)phthalocyaninato-zinc(II) (ZnPc) and bovine serum albumin (BSA) has been investigated using various spectroscopic methods. This work may provide some useful information for understanding the interaction mechanism of anticancer drug-albumin binding and gain insight into the biological activity and metabolism of the drug in blood. Based on analysis of the fluorescence spectra, ZnPc could quench the intrinsic fluorescence of BSA and the quenching mechanism was static by forming a ground state complex.

Population divergence of aggregation pheromone responses in Ips subelongatus in northeastern China.

The Asian larch bark beetle, Ips subelongatus, is considered to be the major pest of larch within its natural range. We investigated the electrophysiological and behavioral characteristics as well as mitochondrial DNA cytochrome oxidase subunit I sequences of I. subelongatus from 13 geographic populations throughout northeastern China in order to explore population divergence of aggregation pheromone responses and the extent of potential genetic divergence.

Micro-MoS2 with excellent reversible sodium-ion storage.

Low storage capacity and poor cycling stability are the main drawbacks of the electrode materials for sodium-ion (Na-ion) batteries, due to the large radius of the Na ion. Here we show that micro-structured molybdenum disulfide (MoS2 ) can exhibit high storage capacity and excellent cycling and rate performances as an anode material for Na-ion batteries by controlling its intercalation depth and optimizing the binder. The former method is to preserve the layered structure of MoS2 , whereas the latter maintains the integrity of the electrode during cycling.

Guest-host interactions and their impacts on structure and performance of nano-MoS2.

Different guest species, including amorphous carbon, polyvinyl pyrrolidone (PVP), ethylene diaminetrimolybdate (EDA) derived small molecules, have been successfully intercalated into a nano-scaled MoS2 (nano-MoS2). These guest species bridge the MoS2 slabs through chemical bonding and their host-guest interactions influence the structure and electrochemical performance of the nano-MoS2. When applied in lithium (Li) and sodium (Na) ion batteries, these MoS2 nanostructures exhibit distinguished intercalation thermodynamics and cycling performances.

Charge dependent photodynamic activity of alanine based zinc phthalocyanines.

In this paper, to minimize the effects of different structure, three alanine-based zinc phthalocyanines (Pcs) of differing charges were engineered and synthesized with the same basic structure. On this premise, the relationship between nature of charge and photodynamic activity was studied. Besides, further verification and explanation of some inconsistent results were also carried out.