Loss of EIF4G2 mediates aggressiveness in distinct human endometrial cancer subpopulations with poor survival outcome in patients.

The non-canonical translation initiation factor EIF4G2 plays essential roles in cellular stress responses via translation of selective mRNA cohorts. Currently there is limited and conflicting information regarding its involvement in cancer development and progression. Here we assessed its role in endometrial cancer (EC), in a cohort of 280 EC patients across different types, grades, and stages, and found that low EIF4G2 expression highly correlated with poor overall- and recurrence-free survival in Grade 2 EC patients, monitored over a period of up to 12 years.

Case of fetal ovarian juvenile granulosa cell tumor: Complications and management.

A prenatal ovarian juvenile granulosa cell tumor (JGCT) is a rare entity which may present as an intra-abdominal cyst. Due to its low incidence, optimal management and timing for intervention remain uncertain. This report presents a case of an intra-abdominal cystic structure in a female fetus, one of the two fetuses in a dichorionic-diamniotic twin pregnancy, detected during routine fetal sonographic surveillance at 30 weeks of gestation.

[THE CONGENITAL TRIGGER THUMB - CLINICAL PRESENTATION AND TREATMENT].

Congenital trigger thumb is found in 0.3% of all children. There is an ongoing debate whether the finding of a congenital trigger thumb is truly congenital or is developmental, although the current tendency in the literature is to see it as a developmental finding.

[MALLET FINGER - DIAGNOSIS, CLASSIFICATION AND TREATMENT].

Mallet finger is a common injury involving the extensor mechanism of the finger. It presents as an inability to extend the distal phalanx of the digit. In the right clinical setting, a thorough examination should be performed and supplemented by adequate radiographs.

Does long-term treatment with Doxil® predispose patients to oral cancer?

We present a possible adverse reaction related to long-term use of Doxil(®) in female patients. We believe that long-term use of Doxil(®) may predispose female patients to oral squamous cell carcinoma. The patients in this report were not exposed to the common risk factors related to oral cancer formation such as smoking or alcohol consumption.

Evaluating the epidemiology and morbidity burden associated with human papillomavirus in Israel: accounting for CIN1 and genital warts in addition to CIN2/3 and cervical cancer.

Background: Human papillomavirus (HPV) infection is mostly associated with cervical cancer (CC). However, it can cause other illnesses as well, all of which impact on people's wellbeing and consume healthcare resources. Measures for prevention or early detection of these conditions differ in their effectiveness and cost.

[Persistent low levels of human chorionic gonadotropin in the serum: investigation and management].

Persistent low levels of human Chorionic Gonadotropin-hCG, the pregnancy hormone, in the serum in the absence of pregnancy or any evidence of Gestational Trophoblastic Disease (GTD) is a diagnostic and therapeutic dilemma. This condition mostly presents during follow-up after patients with a history of GTD or hydatidiform mole or an incidental pregnancy test. Many physicians are not aware of the broad differential diagnosis of this condition which is mostly benign.

[Radical trachelectomy as a fertility-preserving option--operative methods, outcomes and fertility rates].

Radical trachelectomy is a relatively new procedure, performed in early stage cervical cancer in young women who choose to preserve their fertility. Two different techniques have been described in the past few years, vaginal and abdominal radical trachelectomy. This review aims to describe and compare the two procedures with regard to: surgical technique, complications, patient survival and fertility.

Effect of BRCA1/2 mutations on long-term survival of patients with invasive ovarian cancer: the national Israeli study of ovarian cancer.

Purpose: To evaluate the long-term survival of ovarian cancer (OvC) patients in total and by BRCA1/2 mutation status.

Patients And Methods: In a nationwide case-control study on OvC conducted in Israel between 1994 and 1999, 779 Jewish women with epithelial invasive OvC were tested for the three Ashkenazi Jewish founder mutations in BRCA1 (185delAG; 5382insC) and BRCA2 (6174delT) genes and followed for survival up to 2003. Of the 605 women of Ashkenazi origin, 213 (35.

Tumor chemoconversion following surgery, chemotherapy, and normalization of serum tumor markers in a woman with a mixed type germ cell ovarian tumor.

Background: Malignant germ cell tumors of the ovary are often curative after conservative surgery and adjuvant chemotherapy. Persistent tumors despite normalization of serum tumor markers may represent retroconversion to benign masses, but this is rare in ovarian tumors without teratoma elements. The management in such cases has not been defined.