Sodium glycocholate liposome encapsulated semaglutide increases oral bioavailability by promoting intestinal absorption.

The aim of this study was to prepare sodium glycocholate liposomes (SGC-Lip) encapsulating semaglutide (Sml) to improve oral bioavailability and better exert hypoglycemic effect. In this paper, SGC-Lip was prepared by reverse-phase evaporation method with particle size around 140 nm, potential around -27 mV, rounded morphology and better stability. The hypoglycemic and intestinal uptake effects of SGC-Lip and cholesterol-containing liposomes (CH-Lip) were comparatively investigated in rats, and the oral safety of SGC-Lip was examined by cytotoxicity assay.

Eudragit L100-coated nintedanib nanocrystals improve oral bioavailability by reducing drug particle size and maintaining drug supersaturation.

The aim of this study was to prepare nintedanib nanocrystals (BIBF-NCs) to lower the solubility of the drug in the stomach, maintain the supersaturation of the drug in the intestine, and improve the oral absorption of nintedanib (BIBF). In this study, BIBF-NCs were prepared by acid solubilization and alkaline precipitation following nano granding method, with a particle size of 290.80 nm and a zeta potential of -49.

Use of a radiomics-clinical model based on magnetic diffusion-weighted imaging for preoperative prediction of lymph node metastasis in rectal cancer patients.

Rectal cancer is the eighth most prevalent malignancy worldwide with a 3.2% mortality rate and 3.9% incidence rate.

Asymmetry of brain development in adolescent rats studied by 3.0 T magnetic resonance imaging.

To study the developmental patterns of brain structure in adolescent rats based on the registration with the SIGMA template by 3.0T MRI. Forty male Sprague-Dawley rats (180-220 g) were randomly divided into four groups.

Establishment of a Rat Model of Infraorbital Neuroinflammation Under CT Guidance.

Introduction: The aim is to establish a rat model of infraorbital neuroinflammation with less trauma, stable pain, and a long duration of pain. The pathogenesis of TN is not fully clear. There are various models of TN in rats with different disadvantages, such as damaging the surrounding structures and inaccuracy of location for infraorbital nerve (ION).

Preoperative Radiomics Nomogram Based on CT Image Predicts Recurrence-Free Survival After Surgical Resection of Hepatocellular Carcinoma.

Rationale And Objectives: To construct preoperative models based on CT radiomics, radiologic and clinical features to predict recurrence-free survival (RFS) after liver resection (LR) of BCLC 0 to B stage hepatocellular carcinoma (HCC) and to classify the prognosis.

Materials And Methods: This study retrospectively analyzed 161 HCC patients who underwent radical LR. Two methods, the least absolute shrinkage and selection operator and random survival forest analysis, were performed for radiomics signature (RS) construction.

Experience Mode of Digital Media Art under Virtual Reality Technology.

With the progress of the country's comprehensive strength and scientific strength, the development of science and technology has brought tremendous changes to people's lives and at the same time brought information dissemination and media methods to a new stage. This article integrates VR technology into your digital media art experience. This combination not only reduces the distance between the experience and the art but also allows the experiencers to better understand what the artist wants to convey in the artwork.

Novel insights into the role of Clostridium novyi-NT related combination bacteriolytic therapy in solid tumors.

Several solid tumors (for example leiomyosarcoma, melanoma and hepatocellular carcinoma) possess areas of hypoxia, which underlies one of the primary reasons of failure of conventional anticancer therapies. The areas of poor vascularization are insensitive to radiotherapy and chemotherapeutic drugs. Conversely, the hypoxic regions of tumors provide an ideal environment for anaerobic bacteria.

Effects of dietary coated-oleum cinnamomi supplementation on the immunity and intestinal integrity of broiler chickens.

Oleum cinnamomi (OCM) is increasingly used as a feed additive in animal diets. The aim of this study was to investigate the effects of dietary supplementation with coated-OCM (cOCM) on the immunity and intestinal integrity of broiler chickens. A total of 396 one-day-old chicks were randomly assigned into six groups.

Two Species Inhibit the Growth and α-Toxin Production of and Induced Proinflammatory Factors in Chicken Intestinal Epithelial Cells .

is the causative pathogen of avian necrotic enteritis. spp. are well-characterized probiotics with anti-microbial and immune-modulatory activities.