Publications by authors named "Yehan Bian"

Hedgehog signaling plays pivotal roles in embryonic development, adult homeostasis and tumorigenesis. However, its engagement in the pituitary gland has been long underestimated although Hedgehog signaling and pituitary embryogenic development are closely linked. Thus, deregulation of this signaling pathway during pituitary development results in malformation of the gland.

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Article Synopsis
  • The movement of terrestrial vertebrates relies on the diversification of motor neurons into alpha and gamma types, critical for muscle force generation and proprioception.
  • Recent studies have confirmed the genetic differences between these motor neuron types, but the specific mechanisms underlying gamma motor neuron development were unclear.
  • Research shows that the loss of nuclear receptors ERR2 and ERR3 in mice leads to the creation of gamma motor neurons that lack necessary functional properties, impairing movement control, while experiments in chicks suggest these receptors help define the characteristics of gamma motor neurons.
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