Publications by authors named "Yefei Luo"
Reply to van Schie et al.: ARK2N in TCR: Across in vivo and in vitro studies.
Proc Natl Acad Sci U S A
January 2025
Background: China has been exploring HIV self-testing (HIVST) among men who have sex with men (MSM) since 2014. Currently, both non-profit and commercial initiatives HIVST services have achieved comprehensive coverage. Investigating the factors influencing the initial adoption of HIVST among MSM in this context can help develop tailored HIVST service strategies of and further promote HIVST adoption among MSM communities.
View Article and Find Full Text PDFSafeguarding replication fork stability in transcriptionally active regions is crucial for precise DNA replication and mutation prevention. Here, we discover the pervasive existence of replication fork-associated RNA-DNA hybrids (RF-RDs) in transcriptionally active regions of human cells. These hybrids function as protective barriers, preventing DNA2-mediated nascent DNA degradation and replication fork collapse under replication stress.
View Article and Find Full Text PDFPurpose: This study investigated for the HIV-1 CRF59_01B epidemic's spatiotemporal dynamics and its transmission networks in China.
Methods: Between 2007 and 2020, a total of 250 partial pol gene sequences of HIV-1 CRF59_01B were collected from four regions (10 Chinese provinces). Phylogenetic tree construction and cluster identification were then performed.
Objectives: This study investigated the genotype-specific dynamics of molecular HIV clusters (MHCs) in Guangzhou, China, aiming to enhance HIV control.
Methods: HIV pol sequences from people with HIV (PWH) in Guangzhou (2008-2020) were obtained for genotyping and molecular network creation. MHCs were identified and categorized into three types: emerging, growing, or stable.
This study aimed to investigate the impact of sexual partners' HIV serostatus awareness on the HIV acquisition among men who have sex with men (MSM) in Guangzhou, China. A nested case-control study was conducted based on a prospective cohort of MSM in Guangzhou. Within the cohort, individuals who underwent HIV seroconversion were identified as the case group, and each case was matched with four controls from the non-seroconverted participants.
View Article and Find Full Text PDFHuman immunodeficiency virus type 1 CRF59_01B, identified in China in 2013, has been detected nationwide, exhibiting notably high prevalence in Guangzhou and its vicinity. This study aimed to unravel its origin and migration. A data set was established, incorporating all available CRF59_01B pol gene sequences and their metadata from Guangzhou and the public database.
View Article and Find Full Text PDFArticle Synopsis
- Transcription is essential for cellular functions but can be disrupted by the pausing and stalling of RNA polymerase II (RNAPII), with Cockayne syndrome protein B (CSB) facilitating the continuation of transcription or initiating repair processes.
- The study reveals that the ARK2N-CK2 complex is crucial for CSB's role in starting transcription-coupled nucleotide excision repair (TC-NER), being recruited to damage sites by CSB and phosphorylating it.
- Phosphorylation of CSB strengthens its connection to stalled RNAPII, enhancing its interaction with chromatin and encouraging the ubiquitination of RNAPII, ultimately leading to defects similar to those observed in Cockayne syndrome in mice.
Mutations in the BRCA2 tumor suppressor gene have been associated with an increased risk of developing prostate cancer. One of the paradoxes concerning BRCA2 is the fact that its inactivation affects genetic stability and is deleterious for cellular and organismal survival, while BRCA2-mutated cancer cells adapt to this detriment and malignantly proliferate. Therapeutic strategies for tumors arising from BRCA2 mutations may be discovered by understanding these adaptive mechanisms.
View Article and Find Full Text PDFBackground: Since the outbreak started in 2019, COVID-19 pandemic has a significant global impact. Due to the highly infective nature of SARS-CoV-2, the COVID-19 close contacts are at significant risk of contracting COVID-19. China's experience in successfully controlling COVID-19 emphasized the importance of managing close contacts because this strategy helps to limit potential infection sources, prevent the unconscious spread of COVID-19 and thus control this pandemic.
View Article and Find Full Text PDFBackground: With the continuance of the global COVID-19 pandemic, cardiovascular disease (CVD) and cardiac injury have been suggested to be risk factors for severe COVID-19.
Objective: The aim is to evaluate the mortality risks associated with CVD and cardiac injury among hospitalized COVID-19 patients, especially in subgroups of populations in different countries.
Methods: A comprehensive systematic literature search was performed using 9 databases from November 1, 2019 to November 9, 2020.