Publications by authors named "Yeeun Oh"
Microcystin-LRs (MC-LR) produced by harmful cyanobacterial blooms (HCBs) pose significant hepatotoxic risks to both the environment and public health. Despite the identification and characterization of a limited number of MC-LR degrading bacteria, the challenge of safely removing MC-LRs from freshwater systems without disrupting aquatic ecosystems remains substantial. This study focused on the isolation of lactic acid bacteria from Bapshikhe, a traditional Korean fermented food, and investigated the mechanisms underlying the degradation of MC-LRs by these bacteria.
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- Heterologous boost regimens involving an mRNA vaccine after a DNA vaccine are gaining interest for enhancing immunity against SARS-CoV-2.
- In a clinical trial with 32 participants, those who received an mRNA vaccine 6 to 8 months after the GLS-5310 DNA vaccine reported no adverse events, indicating a good safety profile.
- The study found significant improvements in immune responses, with increased antibody and T-cell levels, marking it as the first report on immune responses from this specific vaccination strategy.
Article Synopsis
- The CoV2-001 phase I trial tested the GLS-5310 DNA vaccine for safety and immune response over 48 weeks with 45 participants who had not previously been vaccinated.* -
- Participants received two doses of the vaccine, administered intradermally at varying doses and intervals, and the vaccine was found to be well-tolerated with no serious side effects.* -
- The results showed high antibody and T cell responses, with 95.5% of participants producing anti-spike antibodies and 97.8% showing T cell responses, highlighting the vaccine's strong immunogenicity compared to other vaccines.*
Consumption of alcohol injures DNA, and such damage is considered to be a primary cause for the development of cancer and many other diseases essentially due to reactive oxygen species generated from alcohol. To sensitively detect alcohol-induced DNA lesions in a biological system, we introduced a novel analytical platform for visualization of single genomic DNA molecules using E. coli.
View Article and Find Full Text PDFFluorescent proteins that also bind DNA molecules are useful reagents for a broad range of biological applications because they can be optically localized and tracked within cells, or provide versatile labels for in vitro experiments. We report a novel design for a fluorescent, DNA-binding protein (FP-DBP) that completely 'paints' entire DNA molecules, whereby sequence-independent DNA binding is accomplished by linking a fluorescent protein to two small peptides (KWKWKKA) using lysine for binding to the DNA phosphates, and tryptophan for intercalating between DNA bases. Importantly, this ubiquitous binding motif enables fluorescent proteins (Kd = 14.
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