VPS45 is required for both diffuse and tip growth of cells.

Introduction: VPS45 belongs to the Sec1/Munc18 family of proteins, which interact with and regulate Qa-SNARE function during membrane fusion. We have shown previously that VPS45 interacts with the SYP61/SYP41/VTI12 SNARE complex, which locates on the -Golgi network (TGN). It is required for SYP41 stability, and it functions in cargo trafficking to the vacuole and in cell expansion.