Comparative evaluation of the binding properties of two species of Khaya gum polymer in a paracetamol tablet formulation.

A study was made of the comparative effects of polymers obtained from two species of khaya tree - Khaya senegalensis and Khaya grandifoliola - as binding agents in a paracetamol tablet formulation. The mechanical properties of the tablets were assessed using the tensile strength (T), brittle fracture index (BFI) and friability (F) of the tablets while the drug release properties of the tablets were assessed using disintegration and dissolution times. The tensile strength, disintegration and the dissolution times of tablets increased with the increase in binder concentration while F and BFI decreased.