Publications by authors named "Yedi Huang"
Background & Aims: Although the presence of tertiary lymphoid structures (TLS) correlates with positive responses to immunotherapy in many solid malignancies, the mechanism by which TLS enhances anti-tumor immunity is not well understood. The present study aimed to investigate the underlying cross-talk circuits between B cells and tissue-resident memory T (Trm) cells within the TLS and to understand their role in the context of immunotherapy.
Methods: Immunostaining and hematoxylin and eosin staining of TLS and CXCL13CD103CD8Trm cells were performed on tumor sections from patients with gastric cancer (GC).
Article Synopsis
- Tertiary lymphoid structures (TLS) are linked to better responses to immunotherapy in solid tumors, but their role in enhancing antitumor immunity is often unclear, prompting this study on the interactions between B cells and Trm cells in TLS.
- The study involved examining tumor samples from gastric cancer patients to assess how B cells influence CD103CD8 Trm cells and their ability to combat tumor growth, especially in the context of PD-1 therapy.
- Findings showed that TLS presence and the activation of Trm cells improve anti-PD-1 treatment outcomes, with B cells playing a pivotal role by enhancing Trm cell functions via specific signaling pathways, suggesting new avenues for improving immunotherapy strategies.
Article Synopsis
- The study examines the relationship between gastric microbiota and gastric cancer progression, focusing on how changes in microbiota may relate to immune system dysfunction.
- Using advanced sequencing techniques, researchers analyzed the microbiota from tumor tissues of 53 gastric cancer patients and 30 chronic gastritis patients.
- Key findings reveal that the presence of the Methylobacterium genus is linked to lower immune activity and worse patient outcomes, indicating its potential role in influencing tumor behavior and progression in gastric cancer.