Publications by authors named "Yedarm Park"
Article Synopsis
- The Wnt signaling pathway is crucial for the development and function of organisms, and the Frizzled4 (FZD4) linker domain is important for binding and signaling related to Norrin.
- Research indicates that the FZD linker also plays a key role in binding with Wnt proteins, specifically impacting downstream signaling processes.
- Experiments with FZD chimeras demonstrate that linker swaps between different Frizzled receptors disrupt both canonical (WNT3A) and non-canonical (WNT5A) Wnt signaling pathways by affecting receptor interactions and recruitment of signaling partners.
