Publications by authors named "Yedan Zhu"
Article Synopsis
- - The study aimed to compare the safety of cervical conization (CC) alone versus hysterectomy in patients with adenocarcinoma in situ (AIS) of the cervix, using data from Women's Hospital of Zhejiang University from 2007-2021.
- - Results showed a significantly higher prevalence of residual disease in patients with positive margins (50.6%) compared to negative margins (2.3%), while recurrence rates were similar between both treatment groups: 0.7% for CC alone and 1.3% for hysterectomy.
- - The conclusion highlighted that CC is a safe and effective treatment for AIS if the surgical margins are negative, suggesting it could be preferred over hysterectomy for specific cases.
RAI3 knockdown enhances osteogenic differentiation of bone marrow mesenchymal stem cells via STAT3 signaling pathway.
Biochem Biophys Res Commun
April 2020
Bone marrow mesenchymal stem cells (BMSCs), which have multipotential differentiation and self-renewal ability, have been becoming an attractive source of seed cells for bone tissue engineering. Nonetheless, the precise underlying mechanisms of osteogenesis of BMSCs have not been fully understood. Retinoic acid-induced gene 3 (RAI3) has been found to play important roles in mesenchymal stem cells (MSCs) adipogenesis in our previous study.
View Article and Find Full Text PDFFour compounds T1, T2, T3, and T4 were designed and synthesized as Vorinostat and Belinostat derivatives being the target water-soluble prodrugs. The water solubility of Vorinostat derivatives, T1 and T2, exhibited 400- to 600-fold higher than that of Vorinostat, and Belinostat derivatives, T3 and T4, showed 600- to 750-fold higher than that of Belinostat. Four compounds were evaluated for their inhibitory activities against tumor cell lines HT-29 and Hut-78 in the absence or presence of β-D-glucuronidase.
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