Publications by authors named "Yeboah-Antwi K"

Despite reductions in the number of under-five deaths since the release of the Sustainable Development Goals, the proportion of neonatal deaths among all under-five deaths has remained high. Neonatal health is linked to newborn care practices which are tied to distinct cultural perceptions of health and illness. We assessed how community beliefs in Zambia's Southern Province influence newborn care behaviors, perception of illness, and care-seeking practices, using qualitative data collected between February and April 2010.

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Article Synopsis
  • Preterm birth (PTB) is a major cause of infant mortality globally, and studies show mixed results regarding its rates during COVID-19 lockdowns, with changes ranging from -90% to +30%.
  • Analysis of data from 52 million births in 26 countries indicates modest reductions in PTB rates during the first three months of lockdown, but no significant changes in the fourth month.
  • High-income countries showed an increase in stillbirth risk during the first month of lockdown, with Brazil experiencing increased stillbirth rates throughout the entire lockdown period, highlighting the need for further investigation into these trends.
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Objectives: This prespecified, secondary analysis of the Zambia Chlorhexidine Application Trial (ZamCAT) aimed to determine the proportion of women who did not deliver where they intended, to understand the underlying reasons for the discordance between planned and actual delivery locations; and to assess sociodemographic characteristics associated with concordance of intention and practice.

Design: Prespecified, secondary analysis from randomised controlled trial.

Setting: Recruitment occurred in 90 primary health facilities (HFs) with follow-up in the community in Southern Province, Zambia.

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Objectives: Mothers in resource-limited areas face barriers in initiating care for ill newborns, leading to delays that may contribute to newborn mortality. This qualitative study conducted in rural Lufwanyama District in Zambia aimed to (1) explore mothers' healthcare-seeking related to newborn illness and (2) identify reasons for delaying care-seeking for ill newborns.

Methods: We examined the perspectives of 60 mothers and 77 grandmothers of children under three years of age in 14 focus group discussions as part of the Lufwanyama Integrated Neonatal and Child Health Program study.

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Objective: Determine the sensitivity and specificity of neonatal jaundice visual estimation by primary healthcare workers (PHWs) and physicians as predictors of hyperbilirubinaemia.

Design: Multicentre observational cohort study.

Setting: Hospitals in Chandigarh and Delhi, India; Dhaka, Bangladesh; Durban, South Africa; Kumasi, Ghana; La Paz, Bolivia.

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Article Synopsis
  • The study investigates maternal morbidity rates in low- and middle-income countries, specifically South Asia and sub-Saharan Africa, highlighting that morbidity occurs more often than mortality but is under-researched.
  • Conducted from 2012 to 2015, the research involved monitoring 133,238 pregnancies in nine sites across eight countries, focusing on antenatal, intrapartum, and postnatal periods to collect extensive data on maternal health.
  • The study found that factors like hypertensive disorders, obstetric hemorrhage, and infections had significant associations with maternal, fetal, and neonatal outcomes, providing crucial insights for improving maternal health in these regions.
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Background: Neonatal infection, a leading cause of neonatal death in low- and middle-income countries, is often caused by pathogens acquired during childbirth. Clean delivery kits (CDKs) have shown efficacy in reducing infection-related perinatal and neonatal mortality. However, there remain gaps in our current knowledge, including the effect of individual components, the timeline of protection, and the benefit of CDKs in home and facility deliveries.

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Background: Despite progress made over the past twenty years, child mortality remains high, with 5.3 million children under five years having died in 2018 globally. Pneumonia, diarrhoea, and malaria remain among the commonest causes of under-five mortality; contributing 15%, 8%, and 5% of global mortality respectively.

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Integrated community case management (iCCM) of malaria, diarrhea, and pneumonia is a comprehensive, equitybased strategy to improve treatment access for underserved children under five years old. This paper presents data on cost of iCCM and incremental costs of mHealth enhanced supervision and supply chain management in Zambia. We collected cost data using three questionnaires applied at national, district, health facility and community levels.

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In 2012, approximately 5.6 million Zambians did not have access to improved sanitation and around 2.1 million practiced open defecation.

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Article Synopsis
  • The study explores how traditional beliefs shape newborn care practices and health-seeking behaviors in Southern Province, Zambia, emphasizing the importance of community education for improving neonatal health.* -
  • Through focus groups and interviews, researchers found that community perceptions significantly influenced care-seeking behaviors, and mothers appreciated the health messages shared by ZamCAT field monitors regarding chlorhexidine use.* -
  • Although chlorhexidine did not reduce neonatal mortality, it was positively viewed by the community as it helped prevent umbilical cord infections, highlighting the need for community engagement in health initiatives.*
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Background: Limited qualitative research has been performed in India to investigate views and behaviours of pregnant women regarding malaria despite the threat of malaria-related adverse maternal and neonatal outcomes. To address this gap, a comprehensive study on malaria prevention and treatment attitudes, knowledge and behaviour among pregnant women in India was conducted.

Methods: Pregnant women and healthcare workers (HCWs), encompassing clinic-based providers, traditional birth attendants, and auxiliary nurse-midwives were enrolled for in-depth interviews (IDIs) at 7 hospital sites and nearby communities in Jharkhand and Chhattisgarh States.

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Objective: To assess how quality and availability of reproductive, maternal, neonatal (RMNH) services vary by district wealth and urban/rural status in Zambia.

Methods: We conducted a retrospective analysis of data from the Millennium Development Goal Acceleration Initiative baseline assessment of 117 health facilities in 9 districts. Quality was assessed through a composite score of 23 individual RMNH indicators, ranging from 0 to 1.

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Introduction: Effective community health management information systems (C-HMIS) are important in low-resource countries that rely heavily on community-based health care providers. Zambia currently lacks a functioning C-HMIS to provide real-time, community-based health information from community health workers (CHWs) to health center staff and higher levels of the health system.

Program Description: We developed a C-HMIS mobile platform for use by CHWs providing integrated community case management (iCCM) services and their supervisors to address challenges of frequent stock-outs and inadequate supportive supervision of iCCM-trained CHWs.

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Objective: To evaluate current practices and standards of evaluation and treatment of childhood febrile illness in Southern Province, Zambia.

Methods: From November to December 2013, we conducted a cross-sectional survey of facilities and health workers and we observed the health workers' interactions with febrile children and their caregivers. The facility survey recorded level of staffing, health services provided by the facility, availability and adequacy of medical equipment, availability of basic drugs and supplies and availability of treatment charts and guidelines.

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Background: Chlorhexidine umbilical cord washes reduce neonatal mortality in south Asian populations with high neonatal mortality rates and predominantly home-based deliveries. No data exist for sub-Saharan African populations with lower neonatal mortality rates or mostly facility-based deliveries. We compared the effect of chlorhexidine with dry cord care on neonatal mortality rates in Zambia.

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Article Synopsis
  • Zambia faces a critical shortage of healthcare workers, prompting the Ministry of Health to implement a community health assistant (CHA) programme aimed at improving local health services.
  • A study was conducted to evaluate the effectiveness of the CHAs by comparing treatment rates for diarrhoea, malaria, and pneumonia in areas with and without CHAs, based on surveys of mothers with young children.
  • Results showed a significant increase in treatment rates and immunization for children in areas with CHAs, despite a lack of statistical significance in the overall comparison between the two groups.
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Inadequate hygiene and sanitation remain leading global contributors to morbidity and mortality in children and adults. One strategy for improving sanitation access is community-led total sanitation (CLTS), in which participants are guided into self-realization of the importance of sanitation through activities called "triggering." This qualitative study explored community members' and stakeholders' sanitation, knowledge, perceptions, and behaviors during early CLTS implementation in Zambia.

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Objective: Smoke from burning of biomass fuels has been linked with adverse pregnancy outcomes and hypertension among nonpregnant subjects; association with hypertension during pregnancy has not been well studied. We evaluated whether the use of wood cooking fuel increases the risk of maternal hypertension at delivery compared to gas which burns with less smoke.

Methods: Information on fuel use and blood pressure was available for analysis from a cross-sectional survey of 1369 pregnant women recruited at delivery in India.

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Conducting research in areas with diverse cultures requires attention to community sensitization and involvement. The process of community engagement is described for a large community-based, cluster-randomized, controlled trial comparing daily 4% chlorhexidine umbilical cord wash to dry cord care for neonatal mortality prevention in Southern Province, Zambia. Study preparations required baseline formative ethnographic research, substantial community sensitization, and engagement with three levels of stakeholders, each necessitating different strategies.

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Article Synopsis
  • Conventional microscopy misses a significant number of malarial infections compared to PCR methods, highlighting the presence of submicroscopic infections that could serve as reservoirs for malaria.
  • A study conducted in India evaluated these submicroscopic infections in pregnant women and found that PCR detected higher rates of malaria than microscopy, but these infections did not correlate with negative maternal or fetal outcomes.
  • The findings suggest that, despite the effectiveness of PCR in detecting infections, submicroscopic malaria is not linked to increased risks of anemia or low birth weight during pregnancy, thereby limiting its immediate practical application in field settings.
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Background: The burden of maternal mortality in sub-Saharan Africa is very high. In Ghana maternal mortality ratio was 380 deaths per 100,000 live births in 2013. Skilled birth attendance has been shown to reduce maternal mortality and morbidity, yet in 2010 only 68 percent of mothers in Ghana gave birth with the assistance of skilled birth attendants.

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  • Neonatal illness, particularly sepsis, is a major global cause of death, but the specific causes of community-acquired neonatal bacteremia in developing countries remain underexplored.
  • A study involving 8,889 infants under 2 months from several countries found that about 10.6% of those tested for blood infections had identifiable pathogens, with Staphylococcus aureus and various Gram-negative bacteria being most common.
  • The study highlighted significant antimicrobial resistance, with over half of the isolates resistant to key antibiotics, suggesting urgent need for further investigation into these pathogens and their implications for treatment.*
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Background: Teaming is an accepted approach in health care settings but rarely practiced at the community level in developing countries. Save the Children trained and deployed teams of volunteer community health workers (CHWs) and trained traditional birth attendants (TBAs) to provide essential newborn and curative care for children aged 0-59 months in rural Zambia. This paper assessed whether CHWs and trained TBAs can work as teams to deliver interventions and ensure a continuum of care for all children under-five, including newborns.

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Article Synopsis
  • In Ghana, a significant number of women and girls die from pregnancy-related complications, prompting the Ghana Health Service to train Community Health Officers (CHOs) as midwives to improve skilled attendance in rural areas.
  • A study was conducted through qualitative methods, including interviews with health professionals and community members, to assess participation and roles in the skilled delivery program.
  • Findings revealed that community members, including health volunteers and traditional birth attendants, play vital roles in promoting skilled delivery services, though challenges such as transportation issues and supply shortages remain.
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