Publications by authors named "Ye-ji Kim"

Objective: To assess the utility and challenges of using natural language processing (NLP) in electronic health records (EHRs) to ascertain health-related social needs (HRSNs) among older adults.

Study Setting And Design: We extracted HRSN information using the NLP system Clinical Text Analysis and Knowledge Extraction System (cTAKES), combined with Concept Unique Identifiers and Systematized Nomenclature for Medicine codes. We validated cTAKES performance, via manual chart review, on two HRSNs: food insecurity, which was included in the healthcare system's HRSN screening tool, and housing insecurity, which was not.

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Chlorinated ethenes are prevalent contaminants in industrial wastewater that detrimentally affect human health. As elevated tetrachloroethene (PCE) concentrations (18.0-18.

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Background: Varicella can lead to severe complications in immunocompromised children, including those undergoing hematopoietic stem cell transplantation (HSCT) or chemotherapy. Preventing primary varicella zoster virus (VZV) infection is crucial in these populations to mitigate morbidity and mortality. This study aimed to evaluate the immunogenicity and safety of the live attenuated MAV/06 varicella vaccine in pediatric patients post-HSCT and post-chemotherapy.

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Background: Human placental hydrolysate (hPH) contains anti-inflammatory substances. This study aimed to analyze whether injecting hPH into the subacromial space could reduce pain in patients with shoulder impingement syndrome.

Methods: This single-blind, randomized controlled study enrolled 50 patients with shoulder impingement syndrome who were randomly assigned to either the hPH or placebo groups.

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There are no reports comparing diet recovery between patients who underwent distal gastrectomy (DG) and those who underwent total gastrectomy (TG). The aim of the present study was to compare dietary habits and nutritional status after curative treatment with DG and TG in patients with gastric cancer. We retrospectively collected clinical data from 263 consecutive patients who underwent gastrectomy for gastric cancer without recurrence at a single-center between January 2016 and December 2022.

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Pediatric patients who have undergone hematopoietic stem cell transplantation (HSCT) or chemotherapy are at increased risk for severe influenza complications, necessitating annual vaccination. This study evaluated the immunogenicity and antibody persistence of the 2021-2022 seasonal quadrivalent influenza vaccine in pediatric patients post-HSCT or chemotherapy, compared to healthy controls. A prospective cohort study included 80 pediatric participants divided into three groups: chemotherapy ( = 33), HSCT ( = 27), and healthy controls ( = 20).

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  • The degradation of Pt/C in proton exchange membrane fuel cells (PEMFCs) is primarily caused by carbon corrosion, leading to reduced performance and durability.
  • Researchers developed a unique hollow gyroid structure that effectively fixes electrocatalysts and improves their accessibility during oxygen reduction reactions.
  • These hollow gyroid carbon-Pt nanostructures show 3.6 times more electrochemically active surface area and exhibit exceptional stability due to their optimized hollow design and enhanced chemical properties from the P2VP block.
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Various sensor applications have been developed for protection against hazardous environments, and research on functional materials to enhance performance has also been pursued. The M13 bacteriophage (M13) has found utility in sensor applications like disease diagnosis and detection of harmful substances due to its potential for controlling interaction with target substances through adjustments in electrochemical and mechanical properties via genetic engineering technology. However, while optimizing reactivity or binding affinity between M13 and target materials is crucial for sensor performance enhancement, precise dynamic measurement methods for this were lacking.

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l-3,4-Dihydroxyphenylalanine (levodopa and L-DOPA in this text), alongside dopamine, boasts high biocompatibility, prompting industrial demand for its use as a coating material. Indeed, the effectiveness of L-DOPA is steadily rising as it serves as an oral therapeutic agent for neurodegenerative brain diseases, particularly Parkinson's disease (PD). However, the effects of L-DOPA on the growth and function of astrocytes, the main glial cells, and the most numerous glial cells in the brain, are unknown.

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  • This text discusses how recording and modulation of neuronal activity can help in studying brain function in various health conditions and diseases.
  • It highlights the use of advanced techniques, like optogenetics and chemical sensing, that enhance our understanding of brain chemistry and signaling in rodent models.
  • The study showcases innovative fiber technology that integrates multiple recording methods, which allows researchers to simultaneously monitor and stimulate brain activity while also delivering drugs or genes, particularly in investigating the mesolimbic reward pathway in mice.
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  • Children who experience early life adversity, similar to adults with PTSD, show biased memory for negative emotional events, but the underlying mechanisms are unclear.
  • A study with 56 children (ages 8-14) involved fMRI scans while they viewed different emotional images and later tested their recall.
  • Findings indicate that children with less trauma had stronger emotional memory effects linked to higher brain activity in regions like the amygdala, while highly trauma-exposed children may rely on different neural pathways to process and remember positive emotional experiences.
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Objective: This study aimed to compare the efficacy and tolerability of azithromycin and clarithromycin in pediatric enterocolitis.

Methods: A prospective, randomized, controlled trial was conducted at a single center. Patients with confirmed enterocolitis were randomly assigned to receive either a 3-day course of azithromycin or a 5-day course of clarithromycin.

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  • Deep brain stimulation has greatly advanced the treatment of neurological and psychiatric disorders, and there's interest in finding less invasive alternatives.
  • The study focuses on magnetoelectric nanodiscs (MENDs) that can convert magnetic fields into electric signals to modulate neurons remotely, showing effective results even below traditional stimulation thresholds.
  • When injected into specific brain regions of mice, MENDs can control behaviors related to reward and movement, paving the way for new applications in neuroscience research and therapy.
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  • The study aimed to analyze the frequency and types of complications following reverse total shoulder arthroplasty (RTSA) in a Korean population, as well as their clinical outcomes over more than a year of follow-up.
  • A total of 299 patients were reviewed, with notable improvements in pain and functional scores after surgery, although complications were observed in 15.1% of cases, including scapular stress fractures as the most common issue.
  • The findings indicated a reoperation rate of 2.7% and a revision rate of 2.3%, suggesting that primary RTSA can lead to satisfactory outcomes despite some risks of complications.
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  • A resurgence of Mycoplasma pneumoniae (MP) infections, mainly causing pneumonia in kids, was noted after the COVID-19 pandemic, leading to a study on its clinical features and treatment in late 2023.
  • Out of 474 patients screened, 374 met criteria for MP pneumonia, with most presenting fever and a common radiological sign being lobar consolidation, while macrolide resistance was high at 87%.
  • The study underscores the challenge of treating MP pneumonia due to high macrolide resistance rates, as these antibiotics, along with corticosteroids, are still frequently used despite their ineffectiveness in improving radiological outcomes.
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Objectives: This study aimed to identify the specific vaccine strain associated with herpes zoster (HZ) in children following a series of diagnosed cases and to explore whether differences in single nucleotide polymorphisms (SNPs) among various vaccine strains are linked to an increased incidence of herpes zoster after vaccination.

Methods: From February 2021 to March 2024, children <12 years old suspected of vaccine-related varicella-like rash or HZ were included. Varicella zoster virus DNA isolated from the patients were sequenced to differentiate vaccine type versus wild-type.

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  • NLRP3 is a key sensor in the immune system that detects pathogens and triggers the release of inflammatory proteins like IL-1β and IL-18 through the NLRP3 inflammasome.
  • Abnormal NLRP3 activation is linked to autoinflammatory diseases (e.g., CAPS) and common conditions like Alzheimer's and asthma.
  • Recent research suggests that pyrin and possibly NLRP3 itself function as indirect sensors regulated by inhibitory proteins, and targeting these regulatory mechanisms with new inhibitors could offer new treatments for diseases tied to NLRP3.
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  • Dopamine-modified hyaluronic acid (DA-HA) was originally created for industrial uses, but its effects on brain health are still not well understood.
  • Recent research shows that DA-HA works similarly to dopamine (DA) but has significantly lower toxicity due to reduced autoxidation, which is linked to neuron death.
  • In tests on animals, DA-HA demonstrated lower toxicity compared to a known toxic form of DA and helped improve motor function in a model for Parkinson's disease, suggesting it could be a promising treatment for dopamine-related conditions.
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X-linked juvenile retinoschisis (XLRS) is a hereditary retinal degeneration affecting young males caused by mutations in the retinoschisin () gene. We generated human induced pluripotent stem cells (hiPSCs) from XLRS patients and established three-dimensional retinal organoids (ROs) for disease investigation. This disease model recapitulates the characteristics of XLRS, exhibiting defects in RS1 protein production and photoreceptor cell development.

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  • - The relationship between interfacial science and electroorganic syntheses is crucial since all electrochemical reactions happen at the interface of the electrode and the solution, impacting reaction selectivity.
  • - The review focuses on new examples of electrode surface chemistries that promote selective electroorganic synthesis in three main reaction types: hydrogenation, oxidation, and reductive C–C bond formation.
  • - Various techniques are discussed, including material characterization methods, highlighting how understanding an electrode's surface chemistry can enhance selectivity in electroorganic reactions and improve its catalytic properties.
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Inside germinal centers (GCs), antigen-specific B cells rely on precise interactions with immune cells and strategic localization between the dark and light zones to clonally expand, undergo affinity maturation, and differentiate into long-lived plasma cells or memory B cells. Follicular helper T (Tfh) cells, the key gatekeepers of GC-dependent humoral immunity, exhibit remarkable dynamic positioning within secondary lymphoid tissues and rely on intercellular interactions with antigen-presenting cells (APCs) during their differentiation and execution of B-cell-facilitating functions within GCs. In this review, we briefly cover the transcriptional regulation of Tfh cell differentiation and function and explore the molecular mechanisms governing Tfh cell motility, their interactions with B cells within GCs, and the impact of their dynamic behavior on humoral responses.

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We identified a new human voltage-gated potassium channel blocker, NnK-1, in the jellyfish based on its genomic information. The gene sequence encoding NnK-1 contains 5408 base pairs, with five introns and six exons. The coding sequence of the NnK-1 precursor is 894 nucleotides long and encodes 297 amino acids containing five presumptive ShK-like peptides.

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Trichospira verticillata is an annual herb that belongs to the family Asteraceae. Trichospira verticillata extract (TVE) elicits anti-plasmodial activity; however, there has been no detailed report about its anti-inflammatory effects and molecular mechanisms. In addition, herbal plants exhibit anti-inflammatory effects by suppressing the NLRP3 inflammasome.

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Background: Neutrophilic asthma (NA) is a severe asthma phenotype associated with steroid resistance and IL-1β overproduction; however, the exact mechanism remains unclear. Moreover, the dysfunction of TNF-α signaling pathway, a regulator of IL-1β production, was associated with the deficiency of ovarian tumor protease deubiquitinase with linear linkage specificity (otulin) in autoimmune patients.

Objective: We hypothesized that otulin downregulation in macrophages (Mφ) could trigger Mφ activation via the nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome signaling pathway.

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Synopsis of recent research by authors named "Ye-ji Kim"

  • Ye-Ji Kim's recent research focuses on a diverse array of topics, including the impact of early life adversity on emotional memory in children, the efficacy of antibiotics in treating pediatric enterocolitis, and innovative neuromodulation techniques using magnetoelectric nanodiscs.
  • Findings highlight that childhood adversity may lead to biased emotional memories similar to PTSD, while a study suggests both azithromycin and clarithromycin are effective treatments for enterocolitis in children but with varying tolerability.
  • Additional work includes exploring the complications of shoulder surgeries in Korean populations, understanding macrolide resistance in pneumonia cases post-COVID-19, and investigating novel biomaterials like dopamine-modified hyaluronic acid for lower toxicity and efficient biological activity.