Publications by authors named "Ye-Zhu Hu"
Autoantibodies (AAbs) in the blood of colorectal cancer (CRC) patients have been evaluated for tumor detection. However, it remains uncertain whether these AAbs are specific to tumor-associated antigens. In this study, we explored the IgG and IgM autoantibody repertoires in both the in situ tissue microenvironment and peripheral blood as potential tumor-specific biomarkers.
View Article and Find Full Text PDFPrevious studies have demonstrated strong associations between host genetic factors and Epstein-Barr virus (EBV) VCA-IgA with the risk of nasopharyngeal carcinoma (NPC). However, the specific interplay between host genetics and EBV VCA-IgA on NPC risk is not well understood. In this two-stage case-control study (N = 4804), we utilized interaction and mediation analysis to investigate the interplay between host genetics (genome-wide association study-derived polygenic risk score [PRS]) and EBV VCA-IgA antibody level in the NPC risk.
View Article and Find Full Text PDFA comprehensive predictive model for radiation-induced brain injury in risk stratification and personalized radiotherapy of nasopharyngeal carcinoma.
Radiother Oncol
January 2024
Article Synopsis
- Radiation-induced brain injury (RBI) significantly impacts the quality of life and survival rates for patients with nasopharyngeal carcinoma (NPC), prompting the need for improved risk stratification tools.
- A large study involving 1189 NPC patients undergoing radiotherapy led to the development of a polygenic risk score (PRS) that effectively identifies individuals at high risk for RBI, with suggested adjusted radiation doses to minimize risk based on genetic predisposition.
- The integration of PRS with clinical factors enhanced prediction accuracy for RBI, indicating that personalized treatment strategies could be developed to optimize patient outcomes.
Article Synopsis
- Large-scale genetic studies found several genetic loci linked to nasopharyngeal carcinoma (NPC), prompting further investigation into biological mechanisms behind these associations.
- A follow-up study involving nearly 7,000 NPC cases and over 10,000 controls identified two new susceptibility loci (9q22.33 and 17q12) and confirmed the role of two previously known loci linked to NPC risk.
- Functional analyses revealed that the genes PHF2 and CDKN2B-AS1 at these loci are crucial for NPC development, with risk alleles affecting their expression levels and consequently promoting NPC cell proliferation.
Article Synopsis
- The study investigates the link between human leukocyte antigen (HLA) molecules that present Epstein-Barr virus (EBV) antigens and the risk of nasopharyngeal carcinoma (NPC).
- Researchers analyzed 455 NPC patients and 463 healthy individuals, using HLA-target sequencing and predictive modeling to assess how EBV peptides bind to different HLA supertypes.
- Results showed that specific EBV peptides have different binding affinities related to NPC risk, with one HLA supertype associated with higher risk and another offering a protective effect, highlighting the complex relationship between EBV, HLA, and NPC development.
Article Synopsis
- - Chemoradiation-induced hearing loss (CRIHL) significantly impacts the long-term quality of life for patients with nasopharyngeal carcinoma (NPC), with age, tumor stage, and cisplatin dosage being key risk factors identified in the study.
- - A genome-wide association study (GWAS) on 777 NPC patients found a specific genetic variant (rs1050851) linked to a 5.46-fold increased risk of hearing loss, indicating a potential genetic predisposition associated with the condition.
- - The research suggests a genetic overlap between hereditary deafness and CRIHL, emphasizing the role of synaptic signaling in hearing loss development and allowing for improved risk prediction for personalized prevention strategies.
Article Synopsis
- The study aimed to create a polygenic hazard score (PHS) to predict who would benefit from adjuvant chemotherapy (ACT) in patients with early-stage non-small cell lung cancer (NSCLC).
- It involved a retrospective analysis of 1,395 stage I-II NSCLC patients and included a genome-wide association study to derive the PHS from 37 specific genetic markers.
- The results showed that patients with a low PHS had significantly better outcomes with ACT, particularly stage II patients, suggesting that the PHS could help identify those most likely to benefit from chemotherapy.
Article Synopsis
- Researchers aimed to find genetic mutations that contribute to the risk of familial nasopharyngeal carcinoma (NPC) by studying 13 families with multiple cases of the disease.
- Whole-exome sequencing identified three rare mutations in the POLN gene that showed a strong association with familial NPC and affected the gene’s ability to support viral replication.
- The study concluded that the POLN gene is a susceptibility factor for familial NPC, with mutations leading to decreased protein stability and impaired viral function, highlighting its role in the disease's biology.
Article Synopsis
- Nasopharyngeal carcinoma (NPC) is linked to genetic factors and Epstein-Barr virus infection, making genetic counseling essential for high-risk families.
- A study involving whole-exome sequencing of 502 familial NPC patients revealed rare mutations in known cancer genes and identified 6 new susceptibility genes, with RAD54L showing the highest prevalence.
- Findings suggest that individuals with both rare and common genetic variants face significantly higher NPC risk, paving the way for better risk assessment and prevention strategies for those with a family history of the disease.
Article Synopsis
- - The study analyzed the EBV genomes of 38 patients with a family history of nasopharyngeal carcinoma (NPC) and 47 healthy controls to investigate the viral characteristics associated with familial NPC.
- - Researchers found mutation hotspots in the EBV latent gene regions of familial NPC cases and identified a specific genetic cluster that was significantly more common in these cases compared to controls.
- - Genome-wide association analysis revealed four variants linked to familial NPC, and a set of 34 high-risk EBV haplotypes correlated with an increased risk of familial NPC, suggesting EBV subtypes may play a role in the hereditary nature of the disease.
Article Synopsis
- Plasma Epstein-Barr virus (EBV) DNA load in oral samples is explored as a non-invasive biomarker in predicting outcomes for patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC).
- A study with 1,194 LA-NPC patients in south China revealed that higher oral EBV DNA levels (>2,100 copies/mL) correlate with poorer overall survival and other survival metrics.
- The findings suggest that measuring oral EBV DNA load could improve risk assessment alongside traditional TNM staging, potentially enhancing patient prognosis management.
Article Synopsis
- Epstein-Barr virus (EBV) is linked to pulmonary lymphoepithelioma-like carcinoma (pLELC), a rare lung cancer, but its genomic characteristics in relation to this cancer are not fully understood.
- A study analyzed whole-genome data from EBV isolated in 78 pLELC patients and 37 healthy controls, revealing 3,995 variations, particularly in latent genes, and identified 32 variations significantly associated with pLELC.
- The study established a global overview of EBV genomic profiles in pLELC patients, indicating that the EBV strains from pLELC are more similar to those found in nasopharyngeal carcinoma and showed
Background: Radiation-induced oral mucositis (OM) is one of the most common acute complications for head and neck cancer. Severe OM is associated with radiation treatment breaks, which harms successful tumor management. Radiogenomics studies have indicated that genetic variants are associated with adverse effects of radiotherapy.
View Article and Find Full Text PDFBackground: Radiation-induced brain injury is a nonnegligible issue in the management of cancer patients treated by partial or whole brain irradiation. In particular, temporal lobe injury (TLI), a deleterious late complication in nasopharyngeal carcinoma, greatly affects the long-term life quality of these patients. Although genome-wide association studies (GWASs) have successfully identified single nucleotide polymorphisms (SNPs) associated with radiation toxicity, genetic variants contributing to the radiation-induced brain injury have not yet been assessed.
View Article and Find Full Text PDFBackground: Tissues from tumor patients are important resources for promoting cancer research, and therefore many biobanks have been established to collect tumor tissues; however, the quality of tumor tissues after surgical resection has not been well documented.
Methods: A total of 896 cases of tissues from 12 types of tumors were chosen for this study. First, histopathological examination was conducted to evaluate the tumor cell content; second, microchip electrophoresis was used to determine the RNA integrity number (RIN) in 466 cases of tissues with a tumor cell content ≥ 75%; and, finally, a correlation test was used to analyze the effect of ischemia on RNA integrity in 384 cases of tissues with a recorded ischemia time.
Background: Tissue specimens for nasopharyngeal carcinoma (NPC) research are scarce because of sampling difficulties. Previous studies have suggested non-invasive nasopharyngeal brushing as an effective sampling method for NPC diagnosis. The present study aimed to evaluate the feasibility of nasopharyngeal brushing in the acquisition of NPC nucleic acids for research.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the genetic factors contributing to the poor prognosis of esophageal squamous cell carcinoma (ESCC) by analyzing somatic mutations from tumor-normal sample pairs.
- Researchers identified mutations in multiple genes, notably VANGL1, which were shown to enhance cell growth, and other significant genes linked to survival rates in ESCC patients.
- Functional experiments indicated that certain genes, including miR-4707-5p and MYBL2, play a role in promoting tumor growth and spread, offering potential targets for future treatments.
Aberrant expression of receptor interacting protein kinase 4 (RIPK4), a crucial regulatory protein of Wnt/β-catenin signaling, has recently been reported to be involved in several cancers. Here, we report the potential clinical implication and biological functions of RIPK4 in cervical squamous cell carcinoma (CSCC). One hundred and ninety-eight CSCC cases, 109 low-grade squamous intraepithelial lesions (LSILs), 141 high-grade squamous intraepithelial lesions (HSILs) and 63 chronic cervicitis were collected.
View Article and Find Full Text PDFA number of studies have investigated the association between the NBS1 Glu185Gln (rs1805794, 8360 G>C) polymorphism and risk for urinary system cancer including bladder cancer, prostate cancer, and renal cell cancer; however, the findings are conflicting. We conducted a meta-analysis focusing on eight published studies with 3,542 cases and 4,210 controls to derive a more precise evaluation of the relationship between the NBS1 Glu185Gln polymorphism and urinary system cancer susceptibility. Overall, the NBS1 Glu185Gln polymorphism was significantly related to increased risk for urinary system cancer (homozygous model: odds ratio (OR)=1.
View Article and Find Full Text PDFMicroRNAs (miRNAs), which play a role in tumorigenesis, may also serve as diagnostic or prognostic biomarkers. However, studies on human miRNA profiles in plasma from nasopharyngeal carcinoma (NPC) patients are in their infancy. Here, we used microarrays to perform systematic profiling of human miRNAs in plasma from NPC patients.
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