[Succession Pattern of Phytoplankton and Its Drivers in Lake Luoma, Jiangsu Province].

As a water storage lake for the South-to-North Water Diversion Project, it is crucial to examine changes in aquatic ecosystem structures in Lake Luoma, Jiangsu province. Field sampling was carried out in Lake Luoma monthly from 2014 to 2018 to study the relationship between the phytoplankton community structure and environmental factors. During the studied period, total nitrogen, permanganate index, and electrical conductivity in water column gradually increased, whereas fluoride content declined.

Hydrogen peroxide stress stimulates phosphorylation of FoxO1 in rat aortic endothelial cells.

Aim: To examine whether the phosphorylation of the O subfamily of forkhead transcription factors (FoxO) is involved in response to oxidative stress in rat aortic endothelial cells (RAECs).

Methods: RAECs were treated with H(2)0(2) and phosphorylation status of proteins were evaluated by Western blot analysis. The subcellular localization of FoxO1 was determined by nuclear and cytosolic fractionation followed by Western blot analysis as well as immunocytochemistry.

Epidermal growth factor receptor mutations in plasma DNA samples predict tumor response in Chinese patients with stages IIIB to IV non-small-cell lung cancer.

Purpose: Mutations in the epidermal growth factor receptor (EGFR) kinase domain can predict tumor response to tyrosine kinase inhibitors (TKIs) in non-small-cell lung cancer (NSCLC). However, obtaining tumor tissues for mutation analysis is challenging. We hypothesized that plasma-based EGFR mutation analysis is feasible and has value in predicting tumor response in patients with NSCLC.