Development of hydrogen sulfide donors for anti-atherosclerosis therapeutics research: Challenges and future priorities.

Hydrogen sulfide (HS), a gas transmitter found in eukaryotic organisms, plays an essential role in several physiological processes. HS is one of the three primary biological gas transmission signaling mediators, along with nitric oxide and carbon monoxide. Several animal and experiments have indicated that HS can prevent coronary endothelial mesenchymal transition, reduce the expression of endothelial cell adhesion molecules, and stabilize intravascular plaques, suggesting its potential role in the treatment of atherosclerosis (AS).

Progress in synthesis and antitumor activities of estradiol-linked platinum complex.

Platinum complexes such as cisplatin and caboplatin are widely used in cancer chemotherapy. However, their clinical applications are substantially limited by unexpected toxic side effects. In this review, we discuss the current progress on the design and synthesis of estradiol-linked platinum complexes as the targeted antitumor drugs.