Publications by authors named "Ye-Qiong Xu"
Article Synopsis
- Research shows that ABO blood groups may influence survival rates in gastric cancer (GC) patients.
- A study of 1412 patients indicated that non-AB blood groups had poorer overall survival compared to AB blood group patients, particularly with group A showing the worst prognosis.
- A new prognostic tool created from the study data improved survival prediction accuracy over traditional methods, suggesting group AB is favorable while group A is unfavorable for prognosis after surgery.
Background: Genetic variation of the Kras oncogene is a candidate factor for increasing susceptibility to carcinoma and modulating response of metastatic colorectal cancer (mCRC) patients treated with anti-epidermal growth factor receptor monoclonal antibody (anti-EGFR). However, results from an increasing number of studies concerning the association of Kras gene rs712 and rs61764370 polymorphisms with risk of cancer and treatment of mCRC using anti-EGFR remain equivocal.
Methods: Risk associations were evaluated in 1,661 cases and 2,139 controls from six studies concerning rs712 and 14,796 cases and 14,985 controls from 29 studies concerning rs61764370.
Roles of E-cadherin (CDH1) genetic variations in cancer risk: a meta-analysis.
Asian Pac J Cancer Prev
January 2015
Article Synopsis
- E-Cadherin (CDH1) gene variations may affect cancer invasion and metastasis by changing transcriptional activity in epithelial cells, but studies on its link to cancer risk are inconsistent due to differing lifestyles and genetics.
- A meta-analysis of 57 studies found that three specific CDH1 polymorphisms (-160 C>A, -347 G>GA, and 3'-UTR +54 C>T) were significantly associated with cancer risk, with varying effects depending on the type of cancer.
- Results indicated that the -160 A allele increases prostate cancer risk, while it may decrease colorectal cancer risk; the -347 GAGA genotype heightens overall cancer risk, particularly in colorectal cancer among Asians, while the +
Background: Colorectal cancer is one of the most common malignant tumors worldwide. Loss of imprinting (LOI) of the insulin-like growth factor 2 (IGF2) gene is an epigenetic abnormality observed in human colorectal neoplasms. Our aim was to investigate the feasibility of using the IGF2 imprinting system for targeted gene therapy of colorectal cancer.
View Article and Find Full Text PDFLeptin and leptin receptor have been implicated in processes leading to breast cancer initiation and progression. An A to G transition mutation in codon 223, in exon 6 of the leptin receptor gene (LEPR) can result in glutamine to arginine substitution (Gln223Arg). A variety of case-control studies have been published evaluating the association between LEPR Gln223Arg polymorphism and breast cancer.
View Article and Find Full Text PDFAssociation of OGG1 Ser326Cys polymorphism with colorectal cancer risk: a meta-analysis.
Int J Colorectal Dis
December 2011
Introduction: 8-Oxoguanine DNA glycosylase 1 (OGG1), a key protein involved in the base excision repair pathway, can recognize and excise several lesions from oligodeoxynucleotides with single DNA damage. A C/G polymorphism at 1,245 bp (C1245G) in exon 7 of the OGG1 (Ser326Cys, rs1052133) is found to have a lower enzymatic activity. A variety of case-control studies have been published evaluating the association between OGG1 Ser326Cys polymorphism and colorectal cancer (CRC), though their conclusions were always contradictory.
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