Peptidyl arginine deiminase 4 and its potential role in Alzheimer's disease.

Alzheimer's disease (AD) is the main cause of dementia, and its pathogenesis is still not clear. Peptidyl arginine deiminases 4(PAD4) as one of the important members of PAD family, is the only protein with nuclear transfer function, it can regulate the expression of many proteins through citrullinating histone. PAD4 can also interact with many transcription factors, involved in regulating gene expression.

[The factors predicting early efficacy of intravenous thrombolysis with alteplase in acute ischemic stroke].

Objective: To analyze the factors affecting on early efficacy of intravenous thrombolysis with alteplase.

Methods: The clinical data of 100 acute cerebral infarction patients treated by intravenous thrombolysis with alteplase were retrospectively analyzed. The patients were divided into early effective group and ineffective group, which assessed by National Institute of Health Stroke Scale (NIHSS) with criteria of whether there were > 3 or not at 24 hours after therapy.