Publications by authors named "Ye-Cheng Xiong"
Retinitis pigmentosa (RP) is a heterogeneous group of retinal degenerative diseases in which the final pathological feature is photoreceptor cell apoptosis. Currently, the pathogenesis of RP remains poorly understood and therapeutics are ineffective. 17β-Oestradiol (βE2) is universally acknowledged as a neuroprotective factor in neurodegenerative diseases and has manifested neuroprotective effects in a light-induced retinal degeneration model.
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- Photoreceptor apoptosis is a significant factor in retinal degeneration, and mesenchymal stem cell transplantation (MSCT) has shown potential to protect visual function by counteracting this process.
- Intravitreal MSCT was found to reduce photoreceptor apoptosis and help maintain retinal structure and function in a mouse model, particularly through the role of exosomes derived from stem cells.
- Key mechanisms involved miR-21, a microRNA transferred via exosomes that helps protect photoreceptors from damage, highlighting its importance in the therapeutic effects of MSCT and exosome transplantation (EXOT).
Bone progeria diminished the therapeutic effects of bone marrow mesenchymal stem cells on retinal degeneration.
Biochem Biophys Res Commun
October 2020
Senescence is closely related to the occurrence of retinal degeneration. Recent studies have shown that bone marrow mesenchymal stem cells (BMMSCs) have significant therapeutic effects on retinal degeneration, While BMMSCs suffer from functional decline in bone aging. Whether senescence affects BMMSCs therapy on retinal degeneration remains unknown.
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