Heavy mechanical force decelerates orthodontic tooth movement via Piezo1-induced mitochondrial calcium down-regulation.

Orthodontic tooth movement (OTM) depends on periodontal ligament cells (PDLCs), which sense biomechanical stimuli and initiate alveolar bone remodeling. Light (optimal) forces accelerate OTM, whereas heavy forces decelerate it. However, the mechanisms by which PDLCs sense biomechanical stimuli and affect osteoclastic activities under different mechanical forces (MFs) remain unclear.

Translational regulation of PKD1 by evolutionarily conserved upstream open reading frames.

Mutations in coding sequence and abnormal PKD1 expression levels contribute to the development of autosomal-dominant polycystic kidney disease, the most common genetic disorder. Regulation of PKD1 expression by factors located in the promoter and 3´ UTR have been extensively studied. Less is known about its regulation by 5´ UTR elements.

Titanium nitride sensor for selective NO detection.

Efficient detection methods are needed to monitor nitrogen dioxide (NO), a major NO pollutant from fossil fuel combustion that poses significant threats to both ecology and human health. Current NO detection technologies face limitations in stability and selectivity. Here, we present a transition metal nitride sensor that exhibits exceptional selectivity for NO, demonstrating a sensitivity 30 times greater than that of the strongest interfering gas, NO.

Association of triglyceride glucose-body mass index and left ventricular hypertrophy in patients with IgA nephropathy: a retrospective study.

Introduction: IgA nephropathy (IgAN) is one of the most prevalent forms of glomerulonephritis worldwide, particularly affecting 40-50% of the East Asian population. Cardiovascular mortality represents a leading cause of death in patients with IgAN. Left ventricular hypertrophy (LVH) serves as a predictor of heart failure and cardiovascular mortality.

A novel diagnostic model for fetal coarctation of the aorta with ventricular septal defect.

Background: Our study aimed to develop a novel diagnostic model for fetal coarctation of the aorta with ventricular septal defect(CoA/VSD).

Methods And Results: We respectively included 70 fetuses with suspected CoA/VSD(January 2017-June 2023). After birth, 26 fetuses (26/47, 55.

X-ray pulse compressors in Laue diffraction geometry.

We theoretically investigate the impact of nonlinear dispersion of crystals and multilayers used in Laue-type pulse compressors (LPCs) on chirped x-ray pulse compression, as well as the optimization method for the configuration of LPCs. We also study the application of LPCs to compress chirped x-ray free-electron laser pulses based on the parameters of LCLS-II-HE. The results show that the optimal thickness is half of the Pendellosung period, yielding the best compressor performance with minimal impact from the nonlinear dispersion.

Ion Hydration Enables Generality in Asymmetric Catalysis: Desymmetrization to P-Stereogenic Triarylphosphine Derivatives.

Asymmetric synthesis relies on seamless transmission of stereochemical information from a chiral reagent/catalyst to a prochiral substrate. The disruption by substrates' structural changes presents a hurdle in innovating generality-oriented asymmetric catalysis. Here, we report a strategy for substrate adaptability by exploiting a fundamental physicochemical phenomenon-ion hydration, in developing remote desymmetrization to access P-stereogenic triarylphosphine oxides and sulfides.

Scalable Reshaping of Diamond Particles via Programmable Nanosculpting.

Diamond particles have many interesting properties and possible applications. However, producing diamond particles with well-defined shapes on a large scale is challenging because diamonds are chemically inert and extremely hard. Here, we show that air oxidation, a routine method for purifying diamonds, can be used to precisely shape diamond particles at scale.

Scalable production of ultraflat and ultraflexible diamond membrane.

Diamond is an exceptional material with great potential across various fields owing to its interesting properties. However, despite extensive efforts over the past decades, producing large quantities of desired ultrathin diamond membranes for widespread use remains challenging. Here we demonstrate that edge-exposed exfoliation using sticky tape is a simple, scalable and reliable method for producing ultrathin and transferable polycrystalline diamond membranes.

A Two-Dimensional Superconducting Electron Gas at LaFeO/SrTiO Interfaces.

Transition metal oxide interfaces have garnered great attention due to their fascinating properties that are absent in their bulk counterparts. The high mobility and coexistence of superconductivity and magnetism at these interfaces remain compelling research topics. Here, we first report superconductivity in the 2DEG formed at the LaFeO/SrTiO interfaces, characterized by a superconducting transition temperature () of 333 mK and a superconducting layer thickness of 13.

Effect of high-intensity intermittent rehabilitation training on physical function, gut microbiome and metabolite after percutaneous coronary intervention in patients with coronary heart disease.

Background: Postoperative rehabilitation exercise training after percutaneous coronary intervention (PCI) is crucial for coronary heart disease (CHD) patients in restoring health and preventing recurrence, including high-intensity interval training (HIIT). However, the impact of HIIT on cardiopulmonary function, gut microbiome and metabolite remains underexplored.

Methods: This study included 60 patients with CHD who underwent percutaneous coronary intervention (PCI).

Aspartate aminotransferase to alanine aminotransferase ratio and short-term prognosis of patients with type 2 diabetes hospitalized for heart failure.

Introduction: We aimed to explore the prognostic value of the aspartate aminotransferase to alanine aminotransferase (AST/ALT) ratio in non-surgical patients with type 2 diabetes hospitalized for heart failure.

Material And Methods: Using a large electronic medical record-based cohort of diabetes in China (WECODe), we gathered data on non-surgical hospitalized patients with type 2 diabetes and heart failure from 2011 to 2019. Baseline AST/ALT ratio was calculated.

Flash glucose monitoring system help reduce the frequency of hypoglycemia and hypoglycemic fear behavior in type 1 diabetes patients.

Objective: Hypoglycemia represents a serious acute complication in individuals with type 1 diabetes mellitus (T1DM). In order to more effectively identify and discriminate the occurrence of hypoglycemic events in patients with T1DM, this study aims to evaluate the impact of two distinct glucose monitoring systems-Flash Glucose Monitoring (FGM) and Continuous Glucose Monitoring (CGM)-on the management of blood glucose levels and the emotional responses associated with hypoglycemic episodes in individuals with T1DM.

Method: In this study, a total of 113 patients with type 1 diabetes mellitus were enrolled and allocated to two groups for the implementation of Glucose Monitoring Systems (GMS).

The effect of medroxyprogesterone acetate on apolipoproteins and lipoprotein(a) concentrations in postmenopausal women: A meta-analysis of randomized controlled trials.

Background And Aim: In view of the favorable effect of hormone replacement therapy (HRT) on the lipid profile in postmenopausal women, and the discrepancies that exist on the effect of medroxyprogesterone acetate (MPA) on lipoprotein concentrations and cardiovascular disease (CVD) risk, we conducted this meta-analysis of randomized controlled trials (RCT) to assess the efficacy of MPA on apolipoprotein and lipoprotein(a) concentrations in healthy postmenopausal women.

Methods: A systematic search was conducted across multiple databases, including for English-language papers published up to September 2023 comparing the effect of MPA on ApoA-I, Apo-AII, and Lp(a) levels with those of a control group. A meta-analysis was conducted using a random-effects model, reporting the results as the weighted mean difference (WMD) with a 95 % confidence interval (CI).

Application of 3D-printed resin guides for the removal of molar fiber posts.

Objective: To evaluate the digital guide technique for removing fiber posts from molars and compare it with the conventional microscope-assisted ultrasound method.

Methods: Two mandibular dentition models, each comprising six extracted molars, were prepared. Two thick and straight canals distributed separately in the distal and mesial roots of each molar were selected for placing the fiber posts.

In Situ Forming Injectable Gelatin-Based Antibacterial Bioadhesives for Preventing Postoperative Leakage and Abdominal Adhesions.

Postoperative anastomotic leakage (AL) and abdominal adhesions are two major complications after intestinal surgery, with an incidence of 2-25% for AL and 93% for adhesion. Until now, there is no method addressing AL and abdominal adhesions simultaneously. In this work, Bi-PEG-succinimidyl succinate (PEG-NHS), amino-gelatin (Agel) is combined with cefoperazone-sulbactam (SCF) to prepare a multifunctional bioadhesive (SCF/SEAgel) for the postoperative leakage and adhesion prevention.

Juxtaposed slab dehydration, decarbonation and seismotectonic variation beneath the Philippine subduction zone based on 3-D modeling.

Largescale volcanic eruptions and earthquakes are occurring frequently in the Philippines, and research has shown that slab metamorphism and diversity alter the impacts of subducted oceanic plates by changing water‒carbon productivity and interplate stability. Within the framework of the thermal evolution history of subducting slabs, the relationships between subduction zone seismicity characterized by both regular megathrust earthquakes and slow slip events of various magnitudes and long-term slab dehydration-decarbonation evolution in the Philippines remain poorly understood. Here, we constructed a comprehensive thermal model incorporating 3-D slab geometric data for the incoming plate and a 3-D subduction velocity field based on the MORVEL plate motion dataset for the Philippine subduction zone with high spatial and temporal resolutions.

Reducing semantic ambiguity in domain adaptive semantic segmentation via probabilistic prototypical pixel contrast.

Domain adaptation aims to reduce the model degradation on the target domain caused by the domain shift between the source and target domains. Although encouraging performance has been achieved by combining contrastive learning with the self-training paradigm, they suffer from ambiguous scenarios caused by scale, illumination, or overlapping when deploying deterministic embedding. To address these issues, we propose probabilistic prototypical pixel contrast (PPPC), a universal adaptation framework that models each pixel embedding as a probability via multivariate Gaussian distribution to fully exploit the uncertainty within them, eventually improving the representation quality of the model.

β-catenin-inhibited Sumoylation modification of LKB1 and fatty acid metabolism is critical in renal fibrosis.

Liver kinase B1 (LKB1) is a serine/threonine kinase controlling cell homeostasis. Among post-translational modification, Sumoylation is vital for LKB1 activating adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK), the key regulator in energy metabolism. Of note, AMPK-regulated fatty acid metabolism is highly involved in maintaining normal renal function.

Integrating network pharmacology and experimental verification to study the mechanism of total flavonoids against stress-induced gastric mucosal damage.

Context: L. () has outstanding clinical efficacy in treating both acute and chronic gastroenteritis. However, the definite mechanism remains unclear.