PanoGen++: Domain-adapted text-guided panoramic environment generation for vision-and-language navigation.

Vision-and-language navigation (VLN) tasks require agents to navigate three-dimensional environments guided by natural language instructions, offering substantial potential for diverse applications. However, the scarcity of training data impedes progress in this field. This paper introduces PanoGen++, a novel framework that addresses this limitation by generating varied and pertinent panoramic environments for VLN tasks.

Toward the enhancement of affective brain-computer interfaces using dependence within EEG series.

In recent years, electroencephalogram (EEG)-based emotion recognition technology has made remarkable advances. However, a subtle but crucial problem caused by the sliding window method has long been overlooked, which is the serious quantity mismatch between stimuli and short-term EEG frames. This may be an important factor limiting the performance of the emotion recognition systems.

Dual-mode monolithic column with zwitterion antifouling and aptamer affinity for online specific recognition of okadaic acid.

Developing a functional media for precise identification of trace shellfish toxin would underpin the effective assessment of marine pollution. Herein, a novel monolithic column with a dual-mode strategy integrating antifouling and aptamer bionic affinity recognition was proposed for online specific identification of the marine toxin okadaic acid (OA). The zwitterionic monomer 2-(methacryloyloxy)ethylphosphorylcholine (MPC) and aptamers were synergistically employed to enable efficient reduction of matrix interferences and selective capture of target OA.

PVEye: A Large Posture-Variant Eye Tracking Dataset for Head-Mounted AR Devices.

Eye tracking technology, essential for enhancing user experience in virtual reality (VR) and augmented reality (AR) devices, has been widely incorporated into advanced head-mounted devices like the Apple Vision Pro and PICO 4 Pro, becoming a standard feature. However, dedicated eye tracking datasets for such devices are severely lacking, with existing datasets commonly facing issues like camera skew and low resolution, particularly failing to adequately consider the diversity in wearing postures. To address this gap, we have developed the Posture-Variant Eye Tracking Dataset (PVEye), which includes 11,044,800 high-resolution near-eye images from 104 participants, showcasing a rich variety of wearing postures.

Ultra-Low Bitrate Face Video Compression Based on Conversions from 3D Keypoints to 2D Motion Map.

How to compress face video is a crucial problem for a series of online applications, such as video chat/conference, live broadcasting and remote education. Compared to other natural videos, these face-centric videos owning abundant structural information can be compactly represented and high-quality reconstructed via deep generative models, such that the promising compression performance can be achieved. However, the existing generative face video compression schemes are faced with the inconsistency between the 3D facial motion in the physical world and the face content evolution in the 2D view.

Genomic Characterization of Carbapenemase-Producing ST895 Isolates from Canine Origins Through Whole-Genome Sequencing Analysis.

The widespread application of carbapenems and other broad-spectrum antibiotics has significantly escalated the threat posed by highly drug-resistant to human public health. In this research, we isolated a carbapenem-resistant strain from the feces of pet dogs at a veterinary hospital in Changchun, Jilin Province, China. To gain insights into its genetic makeup and resistance mechanisms, we conducted comprehensive whole-genome sequencing and antimicrobial susceptibility testing on the isolated strain.

SNORD80-guided 2'-O-methylation stabilizes the lncRNA GAS5 to regulate cellular stress responses.

The introns of the gene encoding the long noncoding RNA (lncRNA) GAS5 host up to 10 C/D box small nucleolar RNAs (snoRNAs). However, whether there is a regulatory and functional relationship between these snoRNAs and GAS5 is unknown. Here, we show that the expression of SNORD80, but not the other snoRNAs, parallels GAS5 expression and is regulated alongside GAS5 in response to cellular stress.

Shenshuaikang enema restores the intestinal barrier and microbiota-gut-kidney axis balance to alleviate chronic kidney disease via NF-κB pathway.

Introduction: Chronic kidney disease (CKD) is a chronic progressive disease characterized by abnormalities in kidney structure or function caused by variousfactors. It has become a significant public health problem, posing a threat to human health worldwide. Shenshuaikang enema (SSKE) has demonstrated notable efficacy and safety in treating CKD, although its mechanism of action remains unclear.

Effectiveness and safety of tofacitinib calcineurin inhibitor in interstitial lung disease secondary to anti-MDA5-positive dermatomyositis: a multi-centre cohort study.

Objective: To compare the effectiveness and safety of tofacitinib (TOF) calcineurin inhibitor (CNI) as initial immunosuppressive regimen for anti-melanoma differentiation-associated gene 5-positive dermatomyositis with interstitial lung disease (MDA5+DM-ILD).

Methods: Adult Chinese patients with newly-diagnosed MDA5+DM-ILD (ILD course<3 months) from five tertiary referral centres between April 2014 and January 2023 were included for this retrospective cohort study. The primary effectiveness endpoint was lung transplantation-free survival within 1 year.

Risk factors for lymphatic leakage following radical cystectomy and pelvic lymph node dissection in patients with muscle-invasive bladder cancer.

Background: Lymphatic leakage is a common complication after radical cystectomy and pelvic lymph node dissection (PLND) for muscle-invasive bladder cancer (MIBC).This study aimed to investigate the risk factors contributing to postoperative lymphatic leakage in patients with MIBC.

Materials And Methods: A total of 534 patients undergoing radical cystectomy and PLND were enrolled in the retrospective study at Peking University Third Hospital from January 2010 to July 2023.

Emotional influences on remembering and forgetting explained by frontal and parietal dynamics.

Based on item-method directed forgetting (DF) task, 60 participants were recruited to explore the influence of emotion (negative, neutral, and positive) on memory encoding processing, with all data referring to the encoding phase of the task. Behavioral results showed that participants were more successful at remembering negative pictures that needed to be forgotten, with both higher recognition rates and discrimination accuracy (Pr) compared with neutral pictures. In the brain, parietal activities reflected preferential processing during negative picture viewing through enhanced late parietal positive potentials (LPP) relative to neutral ones.

Prevalence and Risk Factors of Lower Extremity Musculoskeletal Disorders Among Occupational Groups in Key Industries - China, 2018-2023.

What Is Already Known About This Topic?: Lower extremity musculoskeletal diseases (LE-MSDs) have emerged as a significant contributor to the global disease economic burden and worker absenteeism, becoming a global public health concern. However, the epidemic characteristics of LE-MSDs among occupational populations in China are unknown.

What Is Added By This Report?: This report finds that the LE-MSDs prevalence rate among key occupational groups in China is 17.

Bladder mucosal smoothness predicts early recovery of urinary continence after laparoscopic radical prostatectomy.

Background: To propose the bladder mucosal smoothness (BMS) grade and validate a predictive model including MRI parameters preoperatively that can evaluate the early recovery of urinary continence (UC) after laparoscopic radical prostatectomy (LRP).

Methods: A retrospective analysis was conducted on 203 patients (83 patients experienced UI at the three-month follow-up) who underwent LRP in our medical center and were diagnosed with prostate cancer (PCa) from June 2016 to March 2020. Patients' clinicopathological data were collected.

Acupuncture therapy of overactive bladder: An umbrella review and meta-analysis.

Introduction: Overactive bladder (OAB) is a common lower urinary tract symptom of bladder storage dysfunction. Numerous studies have evaluated the efficacy and safety of acupuncture therapy for overactive bladder, but clinical programs and data were largely inconsistent. Therefore, it is necessary to summarize and analyze the published clinical research data in the field.

Efficacy and safety of jaktinib hydrochloride tablets in active axial spondyloarthritis: a multicentre, randomised, double-blind, placebo-controlled phase II clinical trial.

Objective: The objective of this study is to evaluate the efficacy and safety of jaktinib hydrochloride tablets (jaktinib), a Janus kinase inhibitor, in patients with active radiographic axial spondyloarthritis (r-axSpA).

Methods: Adults with active r-axSpA who met modified New York criteria and had an inadequate response to non-steroidal anti-inflammatory drugs were randomised 1:1:1 to receive jaktinib 75 mg two times per day, 100 mg two times per day, or placebo. The primary and key secondary endpoints were Assessment of SpondyloArthritis international Society 20 (ASAS 20) and ASAS 40 responses, respectively, at week 16.

Integrative multi-omics reveals the mechanism of ulcerative colitis treated with Ma-Mu-Ran antidiarrheal capsules.

Rationale: Ulcerative colitis (UC) is a chronic inflammatory gastrointestinal disease typically coexisting with intestinal microbiota dysbiosis, oxidative stress, and an inflammatory response. Although its underlying mechanism of action is unclear, Ma-Mu-Ran Antidiarrheal Capsules (MMRAC) have demonstrated significant therapeutic efficacy for UC.

Methods: The mechanism of action of MMRAC in the treatment of UC model was investigated by combining metabolomics, transcriptomics, and intestinal microbiota detection techniques.

Radiomics for differential diagnosis of Bosniak II-IV renal masses via CT imaging.

Rationale And Objectives: The management of complex renal cysts is guided by the Bosniak classification system, which may be inadequate for risk stratification of patients to determine the appropriate intervention. Radiomics models based on CT imaging may provide additional useful information.

Materials And Methods: A total of 322 patients with Bosniak II-IV cysts were included in the study from January 2010 to December 2019.

Clinical characteristics associated with peripartum maternal bloodstream infection.

Objective: Bloodstream infection (BSI) during the peripartum period is a major cause of maternal morbidity and mortality. However, data on maternal BSI during hospitalization for delivery are limited. This study aimed to investigate the incidence, clinical characteristics, risk factors, microbiological features, and antibiotic resistance patterns of maternal peripartum BSI, with a focus on understanding the role of premature rupture of membranes (PROM), fever, and other risk factors in its development.

Association of acetaminophen use with mortality and renal recovery in patients with sepsis-associated acute kidney injury.

Background: Sepsis-associated acute kidney injury (SA-AKI) is common and associated with poor outcomes in critically ill patients. Acetaminophen is often used as an antipyretic and analgesic drug, but the association of acetaminophen use with mortality and recovery of renal function in SA-AKI patients remain unclear. We aimed to investigate the association between acetaminophen use and outcomes in SA-AKI patients.

DAPK enhances DDX20 protein stability via suppression of TRIM25-mediated ubiquitination-based DDX20 degradation.

We have previously found that the DAPK-DDX20 signaling axis exerts an anti-cancer activity in hepatocellular carcinoma (HCC) by inhibiting the GTPase activity of CDC42, thereby reducing the invasive and migratory capabilities of cancer cells without affecting cell proliferation. DDX20 serves as an intermediate protein regulated by DAPK in the control of CDC42. Specifically, DAPK enhances DDX20 protein levels by suppressing DDX20 degradation.

Single-cell transcriptomics reveal potent extrafollicular B cell response linked with granzyme K CD8 T cell activation in lupus kidney.

Objectives: B and T cells constitute the majority of infiltrating lymphocytes in the kidney and represent the local perpetrators in lupus nephritis (LN), but the underlying pathogenic mechanisms are not well elucidated. The aim of this study is to explore the kidney-specific adaptive immune landscape in patients with active LN at the single-cell level.

Methods: We performed single-cell RNA/B cell receptor (BCR)/T cell receptor (TCR) sequencing analysis on sorting-purified B and T cells from the kidney and paired peripheral blood of patients with active LN, and the periphery of matched controls.

A chitosan-modified tea tree oil self-nanoemulsion improves antibacterial effects in vivo and in vitro and promotes wound healing by influencing metabolic processes against multidrug-resistant bacterial infections.

Infectious diseases, especially multidrug-resistant bacterial infections, have caused crises and majorly disrupted public health and economic stability worldwide. Many natural essential oils, especially tea tree oil, have potential to treat multidrug-resistant bacteria, such as H. pylori and P.

Influence of High-Altitude Residential History on Optimal HbA1c Cutoff for Detecting Abnormal Glucose Metabolism.

Zengmei, Sun, Suyuan Wang, Hua He, Chenghui Zhang, Mingxia Li, Yan Ye, Huiqin Zhang, Xuanyu Yao, Shuyao Sun, Yuanze Du, Yang Zhong, and Yunhong Wu. Influence of high-altitude residential history on optimal HbA1c cutoff for detecting abnormal glucose metabolism. 26:45-54, 2025.

Identification and Potential Clinical Utility of Common Genetic Variants in Gestational Diabetes among Chinese Pregnant Women.

Backgruound: The genetic basis for hyperglycaemia in pregnancy remain unclear. This study aimed to uncover the genetic determinants of gestational diabetes mellitus (GDM) and investigate their applications.

Methods: We performed a meta-analysis of genome-wide association studies (GWAS) for GDM in Chinese women (464 cases and 1,217 controls), followed by de novo replications in an independent Chinese cohort (564 cases and 572 controls) and in silico replication in European (12,332 cases and 131,109 controls) and multi-ethnic populations (5,485 cases and 347,856 controls).