An individual-level probabilistic model and solution for control of infectious diseases.

We present an individual-level probabilistic model to evaluate the effectiveness of two traditional control measures for infectious diseases: the isolation of symptomatic individuals and contact tracing (plus subsequent quarantine). The model allows us to calculate the reproduction number and the generation-time distribution under the two control measures. The model is related to the work of Fraser et al.

Advancements in Plant Gene Editing Technology: From Construct Design to Enhanced Transformation Efficiency.

Plant gene editing technology has significantly advanced in recent years, thereby transforming both biotechnological research and agricultural practices. This review provides a comprehensive summary of recent advancements in this rapidly evolving field, showcasing significant discoveries from improved transformation efficiency to advanced construct design. The primary focus is on the maturation of the Clustered regularly interspaced short palindromic repeats/CRISPR-associated protein (CRISPR/Cas)9 system, which has emerged as a powerful tool for precise gene editing in plants.

METTL16 inhibits pancreatic cancer proliferation and metastasis by promoting MROH8 RNA stability and inhibiting CAPN2 expression.

Background: N6-methyladenosine (m6A) modification plays a crucial role in the progression of various cancers, including pancreatic cancer, by regulating gene expression. However, the specific mechanisms by which m6A affects pancreatic cancer metastasis remain unclear. This study aims to elucidate the role of METTL16, an m6A writer gene, in regulating core genes such as CAPN2 and MROH8, influencing tumor growth and metastasis.

Chirality and Local Electron Density of States in a Two-Dimensional Molecular Crystal Self-Assembled by Prochiral Radical Molecules.

Creating and unveiling chiral systems is important to the development of new materials and devices. In this study, after depositing prochiral radical molecule 3-carbamoyl-2,2,5,5-tetramethyl pyrroline-1-oxyl (CTPO) on a Au(111) substrate, 2D molecular crystals with two chiralities of CTPO molecules have been discovered. A single CTPO molecule is an achiral molecule in three-dimensional space, and it can form chiral configurations after adsorbing on the substrate.

A novel signal channel attention network for multi-modal emotion recognition.

Physiological signal recognition is crucial in emotion recognition, and recent advancements in multi-modal fusion have enabled the integration of various physiological signals for improved recognition tasks. However, current models for emotion recognition with hyper complex multi-modal signals face limitations due to fusion methods and insufficient attention mechanisms, preventing further enhancement in classification performance. To address these challenges, we propose a new model framework named Signal Channel Attention Network (SCA-Net), which comprises three main components: an encoder, an attention fusion module, and a decoder.

Fabrication of Solvent-Free Solid Polymer Electrolytes for Wide-Temperature All-Solid-State Lithium Metal Batteries.

All-solid-state lithium metal batteries (ASSLMBs) have been regarded as promising candidates to settle the safety issues of liquid electrolytes for rechargeable lithium batteries. However, the currently reported gel polymer electrolytes still have flammable liquid solvents, thus leading to the potential safety hazard. Here, solvent-free deep eutectic solid polymer electrolytes (SPEs) are designed and fabricated via an polymerization, which are composed of a poly(vinylidene fluoride-hexafluoropropylene) (PVDF-HFP) electrospun membrane, succinonitrile (SN), poly(ethylene glycol) diacrylate (PEGDA200, = 200 g mol), lithium bis(trifluoromethanesulfonyl)imide (LiTFSI), and lithium difluoro(oxalato)borate (LiDFOB).

[Clinical phenotype and genetic analysis of a rare case with 6p duplication and terminal deletion syndrome].

Objective: To explore the genetic basis for a child with developmental delay and intellectual deficit (DD/ID).

Methods: A child who was admitted to the Maternal and Child Health Care Hospital of Longhua District of Shenzhen City on June 3, 2023 due to DD/ID, craniofacial malformations, and recurrent infections of upper respiratory tract was selected as the study subject. G-banded chromosomal karyotyping was carried out for the child and her parents.

Influence of stent strut and its associated injury on thrombus formation: A dissipative particle dynamics study.

Vascular stent intervention is a pivotal treatment for coronary atherosclerosis, though in-stent thrombosis remains a significant postoperative complication with an unclear underlying mechanism. This study utilized dissipated particle dynamics analysis to investigate the impact of stent and its injury on platelet behavior. The findings suggest that thrombus formation upstream of the stent is mainly initiated by upstream arterial injury, which leads to increased platelet accumulation and activation in that area.

Large negative differential conductance and its transformation in a single radical molecule.

The discovery of negative differential conductance (NDC) in a single molecule and mechanism controlling this phenomenon are important for molecular electronics. We investigated the electronic properties of a typical radical molecule 3-carbamoyl-2,2,5,5-tetramethyl-3-pyrrolin-1-yloxy (CTPO) on an Au(111) surface using low-temperature scanning tunneling microscopy (STM) and inelastic electron tunneling spectroscopy. Large NDC was observed in single CTPO molecules at the boundary of the crystal monolayer.

A simple and efficient gene functional analysis method for studying the growth and development of peach seedlings.

Stable genetic transformation of peach [ (L.) Batsch] still faces many technical challenges, and existing transient expression methods are limited by tissue type or developmental stage, making it difficult to conduct functional analysis of genes regulating shoot growth. To overcome this dilemma, we developed a three-step method for efficient analysis of gene functions during peach seedling growth and development.

Stiffness-Based Evaluation of Hinge Joints in Prefabricated Assembled Multi-Girder Bridges under Operational Conditions.

Presently, the prevailing approaches to assessing hinge joint damage predominantly rely on predefined damage indicators or updating finite element models (FEMs). However, these methods possess certain limitations. The damage indicator method requires high-quality monitoring data and demonstrates variable sensitivities of distinct indicators to damage.

Object Detection in Multispectral Remote Sensing Images Based on Cross-Modal Cross-Attention.

In complex environments a single visible image is not good enough to perceive the environment, this paper proposes a novel dual-stream real-time detector designed for target detection in extreme environments such as nighttime and fog, which is able to efficiently utilise both visible and infrared images to achieve Fast All-Weatherenvironment sensing (FAWDet). Firstly, in order to allow the network to process information from different modalities simultaneously, this paper expands the state-of-the-art end-to-end detector YOLOv8, the backbone is expanded in parallel as a dual stream. Then, for purpose of avoid information loss in the process of network deepening, a cross-modal feature enhancement module is designed in this study, which enhances each modal feature by cross-modal attention mechanisms, thus effectively avoiding information loss and improving the detection capability of small targets.

The functional and structural alterations in brain regions related to the fear network model in panic disorder: A resting-state fMRI and T1-weighted imaging study.

Abnormal functional connectivity (FC) within the fear network model (FNM) has been identified in panic disorder (PD) patients, but the specific local structural and functional properties, as well as effective connectivity (EC), remain poorly understood in PD. The purpose of this study was to investigate the structural and functional patterns of the FNM in PD. Magnetic resonance imaging data were collected from 33 PD patients and 35 healthy controls (HCs).

The lncRNA1-miR6288b-3p-PpTCP4-PpD2 module regulates peach branch number by affecting brassinosteroid biosynthesis.

Branch number is one of the most important agronomic traits of fruit trees such as peach. Little is known about how LncRNA and/or miRNA modules regulate branching through transcription factors. Here, we used molecular and genetic tools to clarify the molecular mechanisms underlying brassinosteroid (BR) altering plant branching.

Electrospun polylactic acid nanofibers membrane with copper ion-loaded clay nanotubes for fresh-keeping packaging.

The plastics derived from fossil fuels for food packaging results in serious environmental problems. Developing environment-friendly materials for food packaging is urgent and essential. In this study, polylactic acid (PLA) composite nanofibers membranes were prepared with good biocompatibility and antibacterial property.

Tandem transcription factors PpNAC1 and PpNAC5 synergistically activate the transcription of the PpPGF to regulate peach softening during fruit ripening.

Peach fruit rapidly soften after harvest, a significant challenge for producers and marketers as it results in rotting fruit and significantly reduces shelf life. In this study, we identified two tandem genes, PpNAC1 and PpNAC5, within the sr (slow ripening) locus. Phylogenetic analysis showed that NAC1 and NAC5 are highly conserved in dicots and that PpNAC1 is the orthologous gene of Non-ripening (NOR) in tomato.

Soluble polyvinylpyrrolidone-based microneedles loaded with Sanguis draconis and Salvia miltiorrhiza for treatment of diabetic wound healing.

Background: Nowadays, diabetic wound healing remains a crucial challenge due to their protracted and uncertain healing process. Traditional Chinese medicine (TCM) has demonstrated the therapeutic value of Sanguis draconis (SD)-Salvia miltiorrhiza (SMR) Herb Pair in diabetic wound healing. However, new administration modes are urgently needed for their convenient and wide-ranging applications.

Plant Growth Promotion and Plant Disease Suppression Induced by Strain GD4a.

, the causative agent of gray mold disease (GMD), invades plants to obtain nutrients and disseminates through airborne conidia in nature. strain GD4a, a beneficial bacterium isolated from switchgrass, shows great potential in managing GMD in plants. However, the precise mechanism by which GD4a confers benefits to plants remains elusive.

Dual Functionality of 6-Methylthioguanine: Synergistic Effects Enhancing the Photolability of DNA Nucleobases.

A small chemical modification of the nucleobase structure can significantly enhance the photoactivity of DNA, which may incur DNA damage, thus holding promising applications in photochemotherapy treatment of cancers or pathogens. However, single substitution confers only limited phototoxicity to DNA. Herein, we combine femtosecond and nanosecond time-resolved spectroscopy with high-level calculations to disentangle the excited-state dynamics of 6-methylthioguanine (me6-TG) under variable wavelength UVA excitation (310-330 nm).

A rapid and efficient Agrobacterium-mediated transient transformation system in grape berries.

Transient transformation is extremely useful for rapid in vivo assessment of gene function, especially for fruit-related genes. Grape berry, while an important fruit crop, is recalcitrant to transient transformation, due to the high turgor pressure in its mesocarp cells that limits the ability of Agrobacterium to penetrate into the tissue. It is urgent to establish a simple transient transformation system for rapid analysis of gene function.