Publications by authors named "Ye Qin"

Background: polyunsaturated fatty acids (PUFAs) are a category of fatty acids that contain omega-3 and omega-6 fatty acids, which constitute a substantial portion of the Western diet and are vital for maintaining human wellness. The extent to which circulating PUFAs influence the effects of BMI on leukocyte telomere length (LTL) is unknown. Additionally, the impact of circulating PUFA on LTL remains controversial in observational studies.

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  • In the pharmaceutical industry, Chinese hamster ovary cells are commonly used to produce traditional monoclonal antibodies, while nanobodies like C-type nanoantibodies (C-Nabs) are emerging as promising next-generation drugs.
  • The study evaluated various expression systems (bacteria, yeast, mammalian cells) for producing C-Nabs, assessing their binding, stability, and resistance to degradation.
  • Results indicated that yeast is the most effective host for producing C-Nabs, which showed better pharmacokinetic properties when tested in mice, supporting their potential as therapeutic candidates.
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Torreya grandis (TG) nuts are highly valued for their rich content of bioactive compounds including lipids, proteins, carbohydrates, phenolic compounds, vitamins, and minerals, credited with numerous health benefits. In addition to their use in various culinary applications, such as baked goods and snacks, TG nuts are valuable source of high-quality oil rich in ω-3 and ω-6 unsaturated fatty acids, which has been shown to have anti-obesity, neuroprotective, and anti-diabetes effects. Besides, the byproducts from TG nuts processing, like the fruit aril and oil cake, are valuable sources of essential oils and proteins, respectively, with notable antioxidant, antimicrobial, and antifungal properties.

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  • Camellia oleifera is an oilseed rich in beneficial substances called polyphenols, known for their health properties, particularly in reducing inflammation.
  • The study investigated the anti-inflammatory effects of different fractions of phenolics extracted from camellia seeds, finding that free phenolics (FP) were the most effective in reducing inflammatory markers and maintaining intestinal barrier function.
  • Molecular docking studies revealed that specific phenolic compounds, like KGRG, showed strong interactions with proteins involved in inflammation, suggesting they could be key components for therapeutic use against inflammation.
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  • Ademetionine 1,4-Butanedisulfonate (SAMe) is a drug used for treating liver disease, depression, and Alzheimer's, primarily produced via fermentation processes, which can lead to contamination from host cell proteins (HCP).
  • HCP poses risks like allergic reactions and affects the drug's quality and safety, with ELISA and mass spectrometry being common methods for measuring these impurities.
  • A study evaluated SAMe from two suppliers, finding low levels of HCP and SAMS residues, while also highlighting the need for effective evaluation of impurities in active pharmaceutical ingredients (API).
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  • Walsh's family resilience theory highlights how families can build resilience during crises, but there's a gap in understanding this among Chinese stroke survivors and their caregivers.
  • The study aims to examine both the direct and indirect relationships impacting family resilience in this context, exploring factors like social support and self-efficacy.
  • Results from a survey of 379 stroke survivors identified key variables affecting resilience, with additional qualitative interviews revealing insights into how families adapt and support each other through challenges.*
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Study Design: Retrospective Case control Study.

Objectives: To analyze the effect of diffuse idiopathic skeletal hyperostosis (DISH) on the occurrence of new thoracolumbar vertebral fragility fractures (VFFs) at different ages.

Methods: A retrospective analysis of 564 patients, including 189 patients who presented with new-onset thoracolumbar VFFs and 375 patients without spinal fractures, was performed in 4 age groups (50-59 years, 60-69 years, 70-79 years, and 80+ years).

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Background: Myasthenia gravis (MG) is a both neuromuscular junction and antibody-mediated autoimmune disease, and its pathogenesis involves the regulation of circular RNAs (circRNAs). However, the role of circ_0076490 in MG and the underlying mechanism remain unknown.

Methods: RNA levels of circ_0076490, microRNA-144-3p (miR-144-3p), and mitogen-activated protein kinase 1 (MAPK1) were detected by quantitative real-time polymerase chain reaction.

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Histone lysine-specific demethylase 1 (LSD1) is frequently overexpressed in triple negative breast cancer (TNBC), which is associated with worse clinical outcome in TNBC patients. However, the underlying mechanisms by which LSD1 promotes TNBC progression remain to be identified. We recently established a genetically engineered murine model by crossing mammary gland conditional LSD1 knockout mice with Brca1-deficient mice to explore the role of LSD1 in TNBC pathogenesis.

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Objective: This study aimed to explore the optimal dose of dexmedetomidine as a 0.59% ropivacaine adjuvant for epidural anesthesia on perioperative hemodynamics and anesthesia efficacy in patients undergoing great saphenous varicose vein surgery.

Methods: A total of 90 patients were randomly divided into three groups: 0.

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Objective: To explore the performance of ultrasound image-based radiomics in predicting World Health Organization (WHO)/International Society of Urological Pathology (ISUP) grading of clear-cell renal cell carcinoma (ccRCC).

Methods: A retrospective study was conducted via histopathological examination on participants with ccRCC from January 2021 to August 2023. Participants were randomly allocated to a training set and a validation set in a 3:1 ratio.

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The WNT5B ligand regulates the non-canonical wingless-related integration site (WNT)-planar cell polarity (PCP) pathway. However, the detailed mechanism underlying the activity of WNT5B in the WNT-PCP pathway in non-small cell lung cancer (NSCLC) is unclear. In this study, we assessed the clinicopathological significance of WNT5B expression in NSCLC specimens.

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Study Objectives: To examine the longer-term effect of physical activity (PA) intervention on sleep quality and whether the effect was heterogeneous between daytime nappers and non-nappers.

Methods: This study was a secondary analysis of a cluster randomized controlled trial in China. Eight villages were randomized 1:1 to intervention or control group.

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Estrogen receptor-positive (ER) breast cancer seriously endangers the women's physical and mental health worldwide and ER targeting therapy is vital. Here, we found that a citrus polymethoxyflavones (PMFs)-rich hydrolysate (C-H) and its major components (nobiletin and 3-methoxynobiletin) potently degrade ERα protein the ubiquitin-proteasome pathway, thereby impairing the proliferation of ER breast cancer cells. Moreover, our study exhibited that C-H combined with tamoxifen (TAM) inhibited the cell proliferation of ER breast cancer in .

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Introduction: How education affects the relationship between sedentary behavior and cognitive function remains unclear. The aim of this study was to investigate the relationship between mentally active sedentary behavior and cognitive function in rural older Chinese across different levels of education.

Methods: Data from 517 participants aged 60 years and older in rural China at baseline, 4 weeks, 8 weeks, 6 months, 12 months, and 24 months were analyzed.

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  • Researchers utilized transmission electron microscopy (TEM) to study kidney structures in mouse models of podocytopathy, focusing on measuring glomerular basement membrane (GBM) and podocyte foot process (PFP) widths manually, which is time-consuming and varies between operators.
  • A new automated deep learning method was developed, achieving high accuracy in segmenting GBM and measuring its width, showing consistent results with manual measurements for both wild-type and mutant mice, although some differences were noted in PFP measurements.
  • The findings indicate that this automated approach can enhance the analysis of podocytopathy by providing reliable morphological distinctions between healthy and diseased kidney structures.
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Epithelioid hemangioendothelioma is a rare vascular malignancy, and currently, there is no standard treatment regimen for this disease and existing treatment options have limited efficacy. In this case report, we present a patient with lung and lymph node metastases from prostate epithelioid hemangioendothelioma who achieved a significant partial response. This was accomplished through alternating nivolumab therapy with ipilimumab and liposomal doxorubicin, resulting in a progression-free-survival more than 6 months to date.

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Major depressive disorder (MDD) is characterized by high rates of disability and death and has become a public health problem that threatens human life and health worldwide. HPA axis disorder and neuroinflammation are two common biological abnormalities in MDD patients. Hsp90 is an important molecular chaperone that is widely distributed in the organism.

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Aim: To identify genetic defects in a Chinese family with congenital posterior polar cataracts and assess the pathogenicity.

Methods: A four-generation Chinese family affected with autosomal dominant congenital cataract was recruited. Nineteen individuals took part in this study including 5 affected and 14 unaffected individuals.

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  • - This study explores the challenges faced by cancer patients who are also raising children, highlighting how illness and treatment can negatively impact their quality of life and parenting responsibilities.
  • - A systematic review was conducted, analyzing qualitative research from various databases, ultimately including 26 studies and 669 participants from 11 countries, focused on real-life parenting experiences.
  • - The findings identified four main themes: the effects of cancer on children's well-being, parenting difficulties, coping strategies used by parents, and diverse parenting needs, which provide valuable insights into the intersection of illness and family dynamics.
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The long-term trends in maternal and child health (MCH) in China and the national-level factors that may be associated with these changes have been poorly explored. This study aimed to assess trends in MCH indicators nationally and separately in urban and rural areas and the impact of public policies over a 30‒year period. An ecological study was conducted using data on neonatal mortality rate (NMR), infant mortality rate (IMR), under-five mortality rate (U5MR), and maternal mortality ratio (MMR) nationally and separately in urban and rural areas in China from 1991 to 2020.

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Purpose: The goal of this study was to evaluate the dose-response relationship between dexmedetomidine and propofol in sedating patients and to determine the optimal dosage of dexmedetomidine during gastrointestinal endoscopy.

Methods: One hundred fifty patients were divided into 5 groups, each receiving a loading dose of dexmedetomidine (0.4, 0.

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Due to the wide application of reporter gene-related visible/NIR-I bioluminescent imaging, multiplexed fluorescence imaging across visible/NIR-I/NIR-II has excellent potential in biomedical research. However, multiplexed imaging applications across those regions have rarely been reported due to the lack of proper fluorophores. Herein, nine squaraine dyes, which exhibit diverse adsorption and emission wavelengths, were synthesized.

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Torreya grandis wax (TGW), a new nut wax and by-product of refined Torreya grandis oil, lacks sufficient research and application. In this study, the gelling behavior in diacylglycerol (DAG) and chemical compositions of TGW were investigated. Compared with four typical natural waxes, TGW exhibited the lowest critical gelling concentration (C, 1 %wt) in DAG.

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