[Research progress on non-coding RNA regulation of macrophage polarization in allergic rhinitis].

Allergic rhinitis (AR) is a chronic non-specific inflammatory disease of the nasal mucosa caused by abnormal activation of the immune system, with alterations in macrophage polarization playing a crucial role in its occurrence and development. Non-coding RNA has been found to play a key role in the polarization of macrophages. This study aims to explore the latest developments in research on the role of non-coding RNA-regulated macrophage polarization in the pathogenesis of AR, with the goal of identifying new approaches and potential targets for the diagnosis and treatment of AR.

Multidimensional applications of prussian blue-based nanoparticles in cancer immunotherapy.

Immunotherapy holds notable progress in the treatment of cancer. However, the clinical therapeutic effect remains a significant challenge due to immune-related side effects, poor immunogenicity, and immunosuppressive microenvironment. Nanoparticles have emerged as a revolutionary tool to surmount these obstacles and amplify the potency of immunotherapeutic agents.

Modulated ringdown comb interferometry for sensing of highly complex gases.

Gas samples relevant to health and the environment typically contain many molecular species that span a huge concentration dynamic range. Mid-infrared frequency comb spectroscopy with high-finesse cavity enhancement has allowed the most sensitive multispecies trace-gas detections so far. However, the robust performance of this technique depends critically on ensuring absorption-path-length enhancement over a broad spectral coverage, which is severely limited by comb-cavity frequency mismatch if strongly absorbing compounds are present.

Ethnic Minority Disparities in the Epidemiology of Metabolic Dysfunction-Associated Steatotic Liver Disease in a Representative Area of China.

Objective: We aimed to evaluate the differences in clinical features and lifestyle between Han and ethnic minority populations in Guangdong Province, China and their impacts on the ever-growing burden of metabolic dysfunction-associated steatotic liver disease (MASLD).

Methods: In this cross-sectional investigation in Guangdong Province, China, one of the most densely populated areas with imbalanced development, multistage stratified random sampling was used. Demographic, socioeconomic, and lifestyle data of participants were collected.

Is Tailored Bismuth Quadruple Therapies (With Clarithromycin or Furazolidone) Based on Fecal Molecular Susceptibility Testing in First-Line Helicobacter pylori Eradication Treatment More Effective? A Three-Arm, Multicenter Randomized Clinical Trial.

Background: Rising antimicrobial resistance has significantly challenged the eradication rates of Helicobacter pylori. Due to its invasive nature, susceptibility testing based on endoscopic biopsy is controversial, while few studies have focused on the efficacy of tailored bismuth quadruple therapies (BQT) based on fecal susceptibility testing as a first-line treatment.

Methods: In this multicenter study, 598 H.

PPIH is a novel diagnostic biomarker associated with immune infiltration in cholangiocarcinoma.

Background: Cholangiocarcinoma (CHOL) is the second most common primary liver malignancy, characterized by high aggressiveness and heterogeneity. It is typically diagnosed at an advanced stage, leading to a poor prognosis. Although Peptidyl Proline Isomerase H (PPIH) has been implicated in various tumors, its role in CHOL remains unexplored.

Integrative analysis of genes provides insights into the molecular and immune characteristics of mitochondria-related genes in atherosclerosis.

Atherosclerosis is a chronic inflammatory disease characterized by lipid accumulation in arterial walls. The role of the interplay between mitochondrial dysfunction and immune inflammation in atherosclerosis is still unclear. This study aimed to investigate the molecular characteristics and immune landscape of mitochondrial hub genes involved in atherosclerosis.

Quantum State-Resolved Structure and Dynamics of C Fullerenes.

The C fullerene molecule has been the subject of intense study for four decades, starting with its identification in the mass spectra of carbon soot in 1985. In this review, we focus on the achievement of ultra-high-resolution spectroscopy of gas phase neutral C, heralded by the observation of quantum state-resolved infrared spectra in 2019. C is now the largest and most symmetric molecule for which rovibrational quantum state resolution has been achieved, motivating the use of large molecules for studying complex quantum systems with symmetries and degrees of freedom not readily available in other composite systems.

A novel optimization method for hazardous materials vehicle routing with temperature-based time windows.

As a concrete achievement of sharing economy, sharing intermediate bulk containers (IBCs) have emerged and developed in recent years. Meanwhile, high temperature is one of the essential factors in routing optimal problems for vehicles with hazardous material (hazmat). Therefore, to address the above issue, a variant of the hazmat vehicle routing problem of sharing IBCs is proposed.

Split crRNA Precisely Assisted Cas12a Expansion Strategy for Simultaneous, Discriminative, and Low-Threshold Determination of Two miRNAs Associated with Multiple Sclerosis.

Multiple sclerosis (MS) can proceed into secondary progressive MS accompanied by persistent neurological deterioration; therefore, accurate diagnosis of MS is of vital significance. Irregularities of microRNAs (miRNAs) expression have been observed in MS, so miRNAs have been evaluated as novel biomarkers and therapeutic targets. Herein, a new strategy named plit crRNA recisely ssisted as12a xpansion (SPACE) was developed for simultaneous, discriminative, and low-threshold determination of two MS-related miRNAs: miRNA-155 and miRNA-326.

sFlt-1, Coagulation Function, and Platelets as Predictors of Preeclampsia.

Objective: To investigate the predictive value of soluble FMS-like tyrosine kinase-1 (sFlt-1), coagulation function, and platelet (PLT) parameters for preeclampsia (PE).

Methods: A prospective study was conducted on women registered and delivered at Shanghai Fifth People's Hospital from October 2020 to December 2021. All eligible pregnant women were recruited at the time of initial registration in the first trimester.

Unravelling OsPHT2;1 function in Chloroplast Phosphorus Homeostasis and Photosynthetic Efficiency under Low Phosphorus Stress in Rice.

Phosphorus (P) deficiency is a critical factor limiting crop productivity, primarily due to its detrimental effects on photosynthesis and dry matter accumulation. In this study, we investigate the role of the rice gene OsPHT2;1 in mediating chloroplast P homeostasis and its subsequent impact on photosynthetic function under low P conditions. Stomatal conductance is typically positively correlated with net photosynthetic rates; however, P deficiency disrupts this relationship, leading to reduced stomatal opening and diminished photosynthetic efficiency.

The Pentose Phosphate Pathway: From Mechanisms to Implications for Gastrointestinal Cancers.

The pentose phosphate pathway (PPP), traditionally recognized for its role in generating nicotinamide adenine dinucleotide phosphate (NADPH) and ribose-5-phosphate (R5P), has emerged as a critical metabolic hub with involvements in various gastrointestinal (GI) cancers. The PPP plays crucial roles in the initiation, development, and tumor microenvironment (TME) of GI cancers by modulating redox homeostasis and providing precursors for nucleotide biosynthesis. Targeting PPP enzymes and their regulatory axis has been a potential strategy in anti-GI cancer therapies.

Mitochondrial Ribosomal Proteins and Cancer.

Mitochondria play key roles in maintaining cell life and cell function, and their dysfunction can lead to cell damage. Mitochondrial ribosomal proteins (MRPs) are encoded by nuclear genes and are assembled within the mitochondria. MRPs are pivotal components of the mitochondrial ribosomes, which are responsible for translating 13 mitochondrial DNA-encoded proteins essential for the mitochondrial respiratory chain.

ThF thin films for solid-state nuclear clocks.

After nearly 50 years of searching, the vacuum ultraviolet Th nuclear isomeric transition has recently been directly laser excited and measured with high spectroscopic precision. Nuclear clocks based on this transition are expected to be more robust than and may outperform current optical atomic clocks. These clocks also promise sensitive tests for new physics beyond the standard model.

Routing Protocol for Underwater Wireless Sensor Networks Based on a Trust Model and Void-Avoided Algorithm.

Underwater wireless sensor networks have a wide range of application prospects in important fields such as ocean exploration and underwater environment monitoring. However, the influence of complex underwater environments makes underwater wireless sensor networks subject to many limitations, such as resource limitation, channel openness, malicious attacks, and other problems. To address the above issues, we propose a routing scheme for underwater wireless networks based on a trust model and Void-Avoided algorithm.

A novel parameterized neutrosophic score function and its application in genetic algorithm.

Efficiency, safety and cost are three major evaluation indexes of warehouse operation. However, the uncertainty of efficiency, safety and cost factors will lead to economic losses and waste of resources. The purpose of this study is to propose a novel parameterized neutrosophic objective-proportionate genetic algorithm model (PNO-PGA) to optimize the above three objectives.

Exploring the Interactome of the Queuine Salvage Protein DUF2419 in .

causes amebiasis, a significant global health issue, with millions affected annually, especially in developing countries. EhDUF2419, an important protein involved in 's queuine salvage pathway and its interaction network, remains unclear. To explore this, we transfected trophozoites with a plasmid encoding Myc-tagged EhDUF2419 and achieved successful overexpression.

[Non-Invasive Test for Assessment of Liver Fibrosis in Chronic Hepatitis B].

Chronic hepatitis B (CHB) is a high-risk condition that requires continuous monitoring and appropriate management during the natural course of the disease. In particular, the assessment of liver fibrosis is crucial for determining the optimal timing of antiviral therapy, evaluating the treatment response, and predicting the occurrence and prognosis of hepatocellular carcinoma (HCC) in the management of CHB. Although a liver biopsy is the gold standard for diagnosing liver inflammation, steatosis, and fibrosis, there has been a growing trend in the use of non-invasive tests, such as serum biomarkers, transient elastography, and shear wave elastography in CHB patients.

Spectral channels increase of multi-wavelength visible laser enabled by SHG-SFG hybrid processes.

Spectral evolution in nonlinear optical processes, such as second harmonic generation (SHG) and sum frequency generation (SFG), plays a crucial role in multi-wavelength generation through nonlinear frequency conversion. In this study, the enhancement of spectral performance in a multi-wavelength visible laser facilitated by SHG-SFG hybrid processes is proposed and demonstrated, for the first time to our knowledge. An output of up to eleven wavelengths can be achieved using a six-wavelength pump.

NSUN5 Facilitates Hepatocellular Carcinoma Progression by Increasing SMAD3 Expression.

Hepatocellular carcinoma (HCC) is characterized by frequent intrahepatic and distant metastases, resulting in a poor prognosis for patients. Epithelial-mesenchymal transition (EMT) plays a pivotal role in this process. However, the expression of NOP2/Sun RNA methyltransferase 5 (NSUN5) in HCC and its role in mediating EMT remain poorly understood.

The therapeutic potential of PX-478 in a murine model of pelvic organ prolapse.

Background: Pelvic organ prolapse (POP), characterised by the downward displacement of pelvic organs, is a prevalent disorder that affects adult women. This study explored the therapeutic potential of PX-478, a selective hypoxia-inducible factor-1α (HIF-1α) inhibitor, in a murine POP model.

Methods: A murine POP model was established through ovariectomy, mimicking oestrogen deprivation.

A synthetic bacterial community engineered from Miscanthus floridulus roots enhances ammonia nitrogen removal in ionic rare earth mine tailings.

Ammonium sulfate, as the primary leaching agent, has caused significant nitrogen pollution in rare earth elements (REEs) mining areas. Phytoremediation is a promising remediation method, relying on the synergistic relationships between plants and their root-associated microbiome. Nevertheless, harnessing the microbiome to accelerate nitrogen transformation and absorption by plants is challenging.