Intramolecular cyclization of -cyano sulfoximines by N-CN bond activation.

Metal-free halogenated anhydrides promote the intramolecular cyclization of -cyano sulfoximines. Trifluoro- or trichloroacetic anhydride (TFAA or TCAA, respectively) activate the -cyano groups of -cyano sulfoximines, leading to the intramolecular cyclization of 2-benzamide--cyano sulfoximines 1. This method results in excellent yields of thiadiazinone 1-oxides 2.

Acid-Catalyzed Hydrolysis and Intramolecular Cyclization of -Cyano Sulfoximines for the Synthesis of Thiadiazine 1-Oxides.

Herein, we describe a novel approach for the practical synthesis of thiadiazine 1-oxides . The first example of an intramolecular cyclization with 2--cyano-sulfonimidoyl amides to form the desired thiadiazine 1-oxides was developed. One-pot acid-induced hydrolysis of the cyano group and the intramolecular cyclocondensation protocol readily provided various heterocyclic frameworks in good to moderate yields.

Cross-Sectional Study on Patient Safety Culture, Patient Safety Competency, and Adverse Events.

This study aims to examine the associations between nurses' perceptions of patient safety culture, patient safety competency, and adverse events. Using convenience sampling, we conducted a cross-sectional study from February to May 2018 in two university hospitals. Furthermore, we performed multiple logistic regression to examine associations between patient safety culture, patient safety competency, and adverse events.

Factors influencing caregiver burden in families of hospitalised patients with lung cancer.

Aims And Objectives: To investigate the factors influencing caregiver burden in families of hospitalised lung cancer patients.

Background: Even though cancer symptoms among hospitalised lung cancer patients are serious and negatively affect caregivers, few research regarding to the factors of caregiver burden in hospitalised lung cancer patient has been carried out.

Design: Cross-sectional, descriptive and correlational study.