Gestational weight trajectory and early offspring growth differed by gestational diabetes: a population-based cohort study.

Aims: To investigate the association of gestational weight gain (GWG) trajectory with early children growth, and explore whether this association varies by gestational diabetes mellitus (GDM) status.

Methods: Maternal weight and offspring anthropometric outcomes before 36 months were extracted from Electronic Medical Record of Zhoushan, China. GWG trajectory was modeled using latent-class trajectory analysis.

The effects of China-recommended gestational weight gain guidelines and the Institute of Medicine guidelines on adverse birth outcomes: A population- based cohort study.

Objectives: This study aimed to assess and compare the Institute of Medicine (IOM) guidelines and the recently published China guidelines regarding their applicability for gestational weight gain (GWG) management among Chinese pregnant women.

Method: Data were extracted from the Electronic Medical Record System of Zhoushan, China. Adverse outcomes include small for gestational age (SGA), large for gestational age (LGA), low birth weight and macrosomia.

Successful management of a pregnancy women with sudden onset of acute pancreatitis: A case report and literature review.

Objective: Hypertriglyceridemia (HTG) is a rare cause of acute pancreatitis (AP) in pregnancies and has emerged as an aggravating factor of severe pancreatitis. To enhance the diagnosis and management of HTG-induced AP during pregnancy by improving early recognition, optimizing treatment strategies, and minimizing maternal and fetal complications.

Case Report: This is a 29-year-old multigravida woman at a gestational age of 34 weeks and 2 days who presented with sudden abdominal pain and vomiting.

Chiral-Polar Photovoltage-Driven Efficient Self-Powered Circularly Polarized Light Detection in Three-Dimensional Hybrid Perovskites.

The chiral-polar photovoltaic effect (CPPE), widely present in chiral hybrid perovskites, has brought an unprecedented opportunity for self-powered circularly polarized light (CPL) detection. However, on account of spatial limitations of the crystal structure, currently reported CPPE primarily focuses on low-dimensional hybrid perovskites, which have a low CPL photoresponse restricted by lower carrier transport efficiency compared to three-dimensional perovskites. For the first time, we reported chiral-polar photovoltage-driven efficient self-powered CPL detection in three-dimensional chiral-polar perovskites, MHyPbBr (MHy = Methylhydrazinium).

Mineral types dominate microbiomes and biogeochemical cycling in acid mine drainage.

Acid mine drainage (AMD) environments are typically used as models to study the crucial roles of acidophilic microbes in aquatic environments. Nevertheless, knowledge regarding microbial-driven biogeochemical cycling across mining regions remains limited. In this study, a metagenomics-based approach was employed to explore the diversity, composition, and ecological functions of microbiomes in global AMD environments with different mineral types.

Stable self-powered X-ray detection with a low detection limit using a green halide hybrid perovskite ferroelectric crystal.

Lead halide hybrid perovskite ferroelectrics show great potential in the field of self-powered X-ray detection due to their excellent X-ray absorption, high carrier mobility, large carrier lifetime, and interesting ferroelectricity. Nonetheless, the toxicity of lead raises concerns regarding safety for humans and the environment, which limits their practical applicability. Herein, we successfully realized stable self-powered X-ray detection with a low detection limit using a lead-free halide hybrid perovskite ferroelectric crystal, [Hmdap]BiBr (1, Hmdap = -methyl-1,3-diaminopropanium), driven by the switchable spontaneous polarization ( ).

Polar Three-dimensional Organic-inorganic Hybrid Perovskite Realize Highly Sensitive Self-driven Ultraviolet Photodetection.

Bulk photovoltaic effect (BPVE) triggered by spontaneous polarization in polar organic-inorganic hybrid perovskites (OIHPs) has brought unprecedented development opportunities for self-powered ultraviolet photodetection. However, the currently reported ultraviolet optoelectronic devices are dominated by low-dimensional hybrid perovskites, in which low carrier mobility limits the photoelectric conversion efficiency. Herein, we report for the first time a polar three-dimensional OIHPs, namely MHyPbBr (1, MHy=methylhydrazine), that achieves high-performance self-driven ultraviolet photodetection.

Advancement Opportunities and Endeavor of Innovative Targeted Therapies for Small Cell Lung Cancer.

Small cell lung cancer (SCLC) is an intractable disease with rapid progression and high mortality, presenting a persistent obstacle impeding clinical management. Although recent advancements in immunotherapy have enhanced the response rates of platinum-based chemotherapy regimens, the emergence of acquired resistance invariably leads to recurrence and metastasis. Consequently, there is an urgent necessity to explore novel therapeutic targets and optimize existing treatment strategies.

Ultra-stable and Sensitive X-ray Detectors Using 3D Hybrid Perovskitoid Single Crystals.

Organic-inorganic hybrid perovskites (OIHPs) have shown great potential for direct X-ray detection in security screening and medical diagnostics. However, their humidity stability is compromised due to the susceptibility of the structural components to water molecules, thereby limiting their practical application. In this work, stable and sensitive X-ray detection is achieved using high-quality bulk single crystals of the 3D perovskitoid (DMPZ)PbBr (DPB, DMPZ = N,N'-dimethyl-pyrazinium), wherein N-acid protons are replaced with hydrophobic alkyl groups.

Red and blue LED light increases the survival rate of random skin flaps in rats after MRSA infection.

Skin flap transplantation is a conventional wound repair method in plastic and reconstructive surgery, but infection and ischemia are common complications. Photobiomodulation (PBM) therapy has shown promise for various medical problems, including wound repair processes, due to its capability to accelerate angiogenesis and relieve inflammation. This study investigated the effect of red and blue light on the survival of random skin flaps in methicillin-resistant Staphylococcus aureus (MRSA)-infected Sprague Dawley (SD) rats.

Association between descending aorta wall thickness or wall area and cardiovascular disease risk factors in cardiovascular disease-free patients: a study based on water-calcium material decomposition and subtraction-based computed tomography dark-blood imaging.

Background: Due to the low contrast between the vascular lumen and vessel wall, conventional computed tomography (CT) is not an effective method for visualizing the vessel wall. The purpose of this study was to assess the feasibility of vessel wall visualization using contrast-enhanced dual-energy CT (DECT)-derived water-calcium material decomposition (WMD) and subtraction-based dark-blood imaging (DBI). An additional objective of this study was to determine the association of descending aorta wall thickness (WT) and wall area (WA) with cardiovascular disease (CVD) risk factors and to ascertain the potential of DECT-derived WT and WA as image markers for identifying individuals at high risk for future CVD.

Unprecedented Ultraviolet Circularly Polarized Light-Dependent Anomalous Photovoltaics in Chiral Hybrid Perovskites.

Circularly Polarized Light (CPL)-dependent anomalous photovoltaic effect (APVE), characterized by light helicity-manipulated steady photocurrent and above-bandgap photovoltage, has demonstrated significant potential in the fields of photoelectronic and photovoltaics. However, exploiting CPL-dependent APVE in chiral hybrid perovskites, a promising family with intrinsic chiroptical activity and non-centrosymmetric structure, remains challenging. Here, leveraging the flexible structural design of chiral alternating cations intercalation-type perovskites, CPL-dependent APV, for the first time, is achieved in chiral perovskites.

Characterization and genomic insights into bacteriophages Kpph1 and Kpph9 against hypervirulent carbapenem-resistant .

The increasing incidence of infections attributed to hypervirulent carbapenem-resistant (Hv-CRKp) is of considerable concern. Bacteriophages, also known as phages, are viruses that specifically infect bacteria; thus, phage-based therapies offer promising alternatives to antibiotic treatments targeting Hv-CRKp infections. In this study, two isolated bacteriophages, Kpph1 and Kpph9, were characterized for their specificity against the Hv-CRKp NUHL30457 strain that possesses a K2 capsule serotype.

Accounting for microorganisms yields stricter water quality criteria and elevated ecological risks of antibiotics: A case study of sulfonamides in the Yangtze River Delta.

The derivation of water quality criteria (WQC) for antibiotics is influenced by the inclusion of various organisms' toxicity data, including microbial data, though no definitive conclusions have been reached. This study focuses on sulfonamide antibiotics, common in the Yangtze River Delta (YRD), to assess the influences of different organisms' toxicity data on determining WQCs and subsequent evaluation of ecological risks. A total of 263 toxicity data points from eight sulfonamides, including sulfamethoxazole (SMX) and sulfamethazine (SM2), were selected to derive WQCs using Species Sensitivity Distribution (SSD) methods.

Association of the comorbidity of gestational diabetes mellitus and hypertension disorders of pregnancy with birth outcomes.

Backgrounds: Many pregnant women suffer from more than one pregnancy complication. However, whether those women experienced a higher risk of adverse birth outcomes is unclear. This study aims to assess the association between the comorbidity of gestational diabetes mellitus (GDM) and hypertension disorders of pregnancy (HDP) and adverse birth outcomes.

Corneal and conjunctival abnormalities in a cohort of survivors from the Western African Ebola virus disease outbreak.

Purpose: To characterize corneal and conjunctival abnormalities (CCAs) and their impact on visual acuity in a cohort of survivors from the Western African Ebola virus disease (EVD) outbreak.

Design: A post hoc analysis of 121 patients, who had previously undergone screening for the Ebola Virus Persistence in Ocular Tissues and Fluids study, was performed.

Methods: Patients underwent a comprehensive ophthalmic exam at the Lowell and Ruth Gess Eye Hospital in Freetown, Sierra Leone.

Ecological features of microbial community linked to stochastic and deterministic assembly processes in acid mine drainage.

Unlabelled: Ecological processes greatly shape microbial community assembly, but the driving factors remain unclear. Here, we compiled a metagenomic data set of microbial communities from global acid mine drainage (AMD) and explored the ecological features of microbial community linked to stochastic and deterministic processes from the perspective of species niche position, interaction patterns, gene functions, and viral infection. Our results showed that dispersal limitation (DL) (48.

Chiral-Polar Alternating Cation Intercalation-Type Perovskite Enables Sensitive Self-Driven X-ray Detection with an Ultralow Detection Limit.

Metal halide perovskites (MHPs) have shown great potential for direct X-ray detection, but achieving high sensitivity without external bias remains challenging. Chiral-polar alternating cation intercalation (ACI)-type MHPs, with excellent optoelectronic properties and a robust chirality-induced bulk photovoltaic effect (BPVE), offer a promising platform for self-driven X-ray detection. Herein, impressive self-driven X-ray detection performance was achieved by utilizing chiral-polar 2D ACI-type perovskite single crystals of (-PPA)PAPbBr (; -PPA = -1-phenylpropylamine; PA = propylamine).

Ozone therapy for knee osteoarthritis: a literature visualization analysis of research hotspots and prospects.

Medical ozone is a molecule composed of three oxygen atoms with anti-inflammatory, analgesic, and antioxidant functions. Ozone therapy (O 3 or O 2 - O 3 ) for knee osteoarthritis has gradually received increasing attention from researchers in recent years. Here, we discuss the research hotspots and development trends of ozone therapy for knee osteoarthritis through literature visualization and analysis.

Polar 3D Perovskitiod Constructed by Asymmetric Diamine for Stable Self-Driven X-Ray Detection.

Polar 3D organic-inorganic hybrid perovskites (OIHPs) with the bulk photovoltaic effect (BPVE) have important application value in self-driven X-ray detection, due to their excellent semiconductor properties. However, A-site cations are limited by the tolerance factor, making it difficult to construct ABX-type polar 3D perovskites. Therefore, it is necessary to explore polar 3D perovskitiods with excellent semiconductor properties for self-driven X-ray detection.

Impact of hepatic steatosis on liver stiffness measurement by vibration-controlled transient elastography and its diagnostic performance for identifying liver fibrosis in patients with chronic hepatitis B.

Objectives: To explore the impact of hepatic steatosis measured by MRI-proton density fat fraction (MRI-PDFF) on liver stiffness measurement (LSM) value and its diagnostic performance for staging liver fibrosis in patients with chronic hepatitis B (CHB).

Methods: A total of 914 patients with CHB who underwent liver biopsy and MRI-PDFF were retrospectively reviewed. The influence of MRI-PDFF on LSM value was assessed using univariate and multivariate linear analyses.

Mechanism of APC truncation involved in colorectal cancer tumorigenesis (Review).

Adenomatous polyposis coli (APC) is widely recognized as a heavily mutated gene that suppresses tumor growth in colorectal cancer (CRC). Its mutation is considered to be the primary and early event that occurs in the development of CRC. In addition, APC has a crucial role in inhibiting the canonical Wnt signaling pathway.

Establishing Vitreoretinal Surgery Capacity in Sierra Leone: Challenges and Opportunities to Address Retinal Health Disparities in Resource-limited Settings.

A range of challenges exists regarding vitreoretinal (VR) surgical services in resource-limited settings, including Sierra Leone. As a result, retinal pathologies may contribute to vision loss and blindness. In the wake of the 2013 to 2016 outbreak of Ebola virus disease in West Africa, gaps in ophthalmic care were underscored as survivors were experiencing a constellation of sequelae, including uveitis and VR disease.