Corneal and conjunctival abnormalities in a cohort of survivors from the Western African Ebola virus disease outbreak.

Purpose: To characterize corneal and conjunctival abnormalities (CCAs) and their impact on visual acuity in a cohort of survivors from the Western African Ebola virus disease (EVD) outbreak.

Design: A post hoc analysis of 121 patients, who had previously undergone screening for the Ebola Virus Persistence in Ocular Tissues and Fluids study, was performed.

Methods: Patients underwent a comprehensive ophthalmic exam at the Lowell and Ruth Gess Eye Hospital in Freetown, Sierra Leone.

Ecological features of microbial community linked to stochastic and deterministic assembly processes in acid mine drainage.

Unlabelled: Ecological processes greatly shape microbial community assembly, but the driving factors remain unclear. Here, we compiled a metagenomic data set of microbial communities from global acid mine drainage (AMD) and explored the ecological features of microbial community linked to stochastic and deterministic processes from the perspective of species niche position, interaction patterns, gene functions, and viral infection. Our results showed that dispersal limitation (DL) (48.

Chiral-Polar Alternating Cation Intercalation-Type Perovskite Enables Sensitive Self-Driven X-ray Detection with an Ultralow Detection Limit.

Metal halide perovskites (MHPs) have shown great potential for direct X-ray detection, but achieving high sensitivity without external bias remains challenging. Chiral-polar alternating cation intercalation (ACI)-type MHPs, with excellent optoelectronic properties and a robust chirality-induced bulk photovoltaic effect (BPVE), offer a promising platform for self-driven X-ray detection. Herein, impressive self-driven X-ray detection performance was achieved by utilizing chiral-polar 2D ACI-type perovskite single crystals of (-PPA)PAPbBr (; -PPA = -1-phenylpropylamine; PA = propylamine).

Ozone therapy for knee osteoarthritis: a literature visualization analysis of research hotspots and prospects.

Medical ozone is a molecule composed of three oxygen atoms with anti-inflammatory, analgesic, and antioxidant functions. Ozone therapy (O3 or O2- O3) for knee osteoarthritis has gradually received increasing attention from researchers in recent years. Here, we discuss the research hotspots and development trends of ozone therapy for knee osteoarthritis through literature visualization and analysis.

Polar 3D Perovskitiod Constructed by Asymmetric Diamine for Stable Self-Driven X-Ray Detection.

Polar 3D organic-inorganic hybrid perovskites (OIHPs) with the bulk photovoltaic effect (BPVE) have important application value in self-driven X-ray detection, due to their excellent semiconductor properties. However, A-site cations are limited by the tolerance factor, making it difficult to construct ABX-type polar 3D perovskites. Therefore, it is necessary to explore polar 3D perovskitiods with excellent semiconductor properties for self-driven X-ray detection.

Impact of hepatic steatosis on liver stiffness measurement by vibration-controlled transient elastography and its diagnostic performance for identifying liver fibrosis in patients with chronic hepatitis B.

Objectives: To explore the impact of hepatic steatosis measured by MRI-proton density fat fraction (MRI-PDFF) on liver stiffness measurement (LSM) value and its diagnostic performance for staging liver fibrosis in patients with chronic hepatitis B (CHB).

Methods: A total of 914 patients with CHB who underwent liver biopsy and MRI-PDFF were retrospectively reviewed. The influence of MRI-PDFF on LSM value was assessed using univariate and multivariate linear analyses.

Mechanism of APC truncation involved in colorectal cancer tumorigenesis (Review).

Adenomatous polyposis coli (APC) is widely recognized as a heavily mutated gene that suppresses tumor growth in colorectal cancer (CRC). Its mutation is considered to be the primary and early event that occurs in the development of CRC. In addition, APC has a crucial role in inhibiting the canonical Wnt signaling pathway.

Esophageal cancer risk is influenced by genetically determined blood metabolites.

It remains unclear what causes esophageal cancer (EC), but blood metabolites have been connected to it. Our study performed a Mendelian randomization (MR) analysis to assess the causality from genetically proxied 1400 blood metabolites to EC level. A two-sample MR analysis was employed to evaluate the causal relationship between 1400 blood metabolites and EC.

Durable Photo-Pyroelectric Detection in a Diamine-Constructed Lead-Free Hybrid Perovskite Ferroelectric.

As a subcategory of pyroelectric materials, hybrid perovskite ferroelectrics possess substantial pyroelectric properties and exceptional light absorption characteristics, demonstrating significant potential in the photo-pyroelectric (PPE) detection field. Despite the significant advantages of hybrid perovskite ferroelectric materials for PPE detection, both the lead issue and the weak stability from van der Waals interactions in monoamines have hindered their further application. Here, 1D lead-free ferroelectric (BDA)SbBr (1, where BDA is 1,4-butanediammonium) is fabricated to achieve PPE detection.

Effects of thyroid hormones modify the association between pre-pregnancy obesity and GDM: evidence from a mediation analysis.

Objective: Conflicting associations have been noted between thyroid function and gestational diabetes mellitus (GDM), with indications that pre-pregnancy BMI might influence these relationships. This study aims to examine the effect of thyroid hormone indices and their mediation role on the risk of GDM.

Methods: Pregnant women in our study were recruited from the Zhoushan Pregnant Women Cohort, Zhejiang Province, China.

Multi-media environmental fate of polychlorinated dibenzo-p-dioxins and dibenzofurans in China: A systematic review of emissions, presence, transport modeling and health risks.

Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) are notorious persistent organic pollutants (POPs) with proven toxicity to human and ecosystems. This review critically evaluates existing research, emphasizing knowledge gaps regarding PCDD/F emissions, environmental behavior, human exposure, and associated risks in China. The current emission inventory of PCDD/Fs in China remains highly uncertain, both in terms of total emissions and emission trends.

Identification and quantitative analysis of genotoxic impurities in rifampicin: Development and validation of a targeted LC-MS/MS method for 1-amino-4-methylpiperazine.

Rifampicin, essential for long-term tuberculosis treatment, requires rigorous control of non-therapeutic impurities due to their potential adverse, including mutagenic effects. Reports on control strategies for genotoxic impurities in rifampicin have been limited. This study introduced an analytical method to identify potential genotoxic impurities from the synthesis of raw materials.

25-Hydroxyvitamin D, Vitamin D Binding Protein and Gestational Diabetes Mellitus: A Two-Sample Mendelian Randomization Study.

Background: Numerous studies have examined whether vitamin D is associated with gestational diabetes mellitus (GDM). Nevertheless, it is still challenging to determine the causality, due to a number of shortcomings in observational research and randomized controlled trials.

Objective: Mendelian randomization (MR) with two samples was conducted to investigate the potential causative association between 25-hydroxyvitamin D (25(OH)D), vitamin D binding protein (VDBP) and GDM risk.

The association of Chinese and American antenatal care utilization indices with birth outcomes.

Objective: Few comparisons have been implemented between different prenatal care utilization indices and their effects on adverse outcomes. This study investigated the appropriateness of Chinese antenatal care (ANC) regulations and compared Chinese and American adequacy of prenatal care utilization (APNCU) scores.

Methods: From 2010 to 2022, the medical records of 60,114 pregnant women were collected from the electronic medical record system (EMRS) in Zhoushan, China.

Suprachoroidal Drug Delivery for Macular Edema Associated With Noninfectious Uveitis.

To evaluate clinical trials in the literature that focus on suprachoroidal drug delivery for the treatment of noninfectious uveitis and other posterior segment diseases. A synthesis of the literature was performed. In 2021, suprachoroidal space triamcinolone acetonide, a corticosteroid delivery system used for the treatment of uveitic macular edema (ME), was approved by the US Food and Drug Administration.

The Complete Mitogenome of Y.Li & S.Lan and Comparative Analysis of Mitogenomes across Orchidaceae.

belongs to the genus and is part of the basal lineage in the phylogenetic tree of the Orchidaceae. Currently, there are only ten reported complete mitochondrial genomes in orchids, which greatly hinders the understanding of mitochondrial evolution in Orchidaceae. Therefore, we assembled and annotated the mitochondrial genome of , which has a length of 573,612 bp and a GC content of 44.

Unintentional emissions of polychlorinated naphthalenes in China: Sources, composition, and historical trends.

Polychlorinated naphthalenes (PCNs) are detrimental to human health and the environment. With the commercial production of PCNs banned, unintentional releases have emerged as a significant environmental source. However, relevant information is still scarce.

Building High-Density Polar Hybrid Perovskites via Intercalation of Cs and Aromatic Diamine for Passive X-ray Detection.

2D organic-inorganic hybrid perovskites (OIHPs) have shown great promise in direct X-ray detection. The development of high-performance passive X-ray detectors in 2D OIHPs calls for an increase in material density while maintaining structural polarity, which is becoming quite challenging. Here, a high-density, polar 2D alternating-cation-intercalated (ACI) perovskite, (4-AP)CsPbI (, 4-AP = 4-amidinopyridinium), capable of addressing this problem is successfully constructed by introducing heavy Cs into the interlayer space of an aromatic Dion-Jacobson (DJ) perovskite (4-AP)PbI ().

Multi-Axial Self-Driven X-Ray Detection by a Two-Dimensional Biaxial Hybrid Organic-Inorganic Perovskite Ferroelectric.

Metal halide perovskite ferroelectrics combining spontaneous polarization and excellent semiconducting properties is an ideal platform for enabling self-driven X-ray detection. However, achievements to date have been only based on uniaxiality, which increases the complexity of device fabrication. Multi-axial ferroelectric materials have multiple equivalent polarization directions, making them potentially amenable to multi-axial self-driven X-ray detection, but the report on these types of materials is still a huge blank.

Genome-Based Identification of the Dof Gene Family in Three Species and Their Responses to Heat Stress in .

As an important genus in Orchidaceae, has rich ecological diversity and significant economic value. DNA binding with one zinc finger (Dof) proteins are pivotal plant-specific transcription factors that play crucial roles in the growth, development, and stress response of plants. Although the Dof genes have been identified and functionally analyzed in numerous plants, exploration in Orchidaceae remains limited.

Genome-Wide Identification and Expression Pattern Analysis of GATA Gene Family in Orchidaceae.

The GATA transcription factors play crucial roles in plant growth, development, and responses to environmental stress. Despite extensive studies of GATA genes in many plants, their specific functions and mechanisms in orchids remain unexplored. In our study, a total of 149 GATA genes were identified in the genomes of seven sequenced orchid species (20 , 23 , 24 , 23 , 20 , 27 , and 12 ), classified into four subfamilies.