Publications by authors named "Ye Hee Lee"
Acute ischemic stroke is a cerebrovascular disease associated with high mortality and severe aftereffects which is caused by the blockage of cerebral blood vessels by a thrombus or embolus. Treatments for this condition are extremely limited. Herein, we aimed to explore the potential of 2,3,4-trihydroxybenzophenone (THB), a drug that suppresses oxidative stress and neuroinflammation, to promote functional recovery through neurite outgrowth, and to identify its protective effects in a mouse model of ischemic stroke.
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- Stress is a natural part of life that can lead to neuropsychiatric disorders, making effective stress management vital for health.
- The study found that ethyl pyruvate (EP) can protect against cognitive decline induced by stress by blocking the effects of the stress hormone corticosterone on long-term potentiation (LTP) in the brain.
- While EP did not reduce anxiety caused by stress, it improved cognitive function and increased neurogenesis in the hippocampus, likely through the regulation of Akt/GSK-3β signaling pathways.
Alzheimer's disease (AD) is the most common degenerative disease and is indicative of dementia. The cerebral accumulation of amyloid β (Aβ), a crucial factor in AD, initiates synaptic and cognitive dysfunction. Therefore, the elevation of synaptic and cognitive functions may help manage dementia in AD.
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