Nanoparticle-mediated light-driven LAMP combined with test strips for sensitive and rapid visual detection of antibiotic resistance genes.

Antibiotic resistance genes (ARGs) are markers of drug-resistant pathogens, monitoring them contributes to prevent resistance to drugs. The detection methods for ARGs including PCR and isothermal amplification are sensitive and selective. However, it may take several hours or cannot be used on spot.

Novel Perspectives Focused on the Relationship Between Herpesvirus Encephalitis and Anti-GFAP-Antibody-Positive Astrocytopathy.

Virus encephalitis (VE), recognized as one of the common kinds of central nervous system (CNS) diseases after virus infection, has a surprising correlation with autoimmune encephalitis (AE) when autoimmune antibodies emerge in cerebrospinal fluid (CSF) or serum. Herpes simplex virus and Epstein-Barr virus are the most critical agents worldwide. By molecular mimicry, herpes viruses can invade the brain directly or indirectly.

Revealing systematic changes in the transcriptome during the transition from exponential growth to stationary phase.

Unlabelled: The composition of bacterial transcriptomes is determined by the transcriptional regulatory network (TRN). The TRN regulates the transition from one physiological state to another. Here, we use independent component analysis to monitor the composition of the transcriptome during the transition from the exponential growth phase to the stationary phase.

O-band EML and 4-bits DAC enabled 112 GBaud PAM8 transmission over a 10 km SSMF without optical amplifiers.

The increasing traffic of intra-data center networks creates an urgent demand for low-cost and high-speed intensity modulation/direct detection (IM/DD) transmission. In this Letter, we propose a joint scheme combining nonlinear lookup table (NL-LUT) pre-distortion, digital pre-emphasis (DPE), and a digital resolution enhancer (DRE) to achieve high-speed and low-cost IM/DD optical links using a low-resolution digital-to-analog converter (DAC). The NL-LUT and DPE are responsible for the system nonlinear impairments and channel attenuation at high frequency, respectively, while DRE handles the quantization noise (QN) caused by high peak-to-average ratios (PAPRs) and low-resolution DAC.

Multi-Wavelength Narrow-Spacing Laser Frequency Stabilization Technology Based on Fabry-Perot Etalon.

Classical frequency-stabilized lasers have achieved high-frequency stability and reproducibility; however, their extensive wavelength spacing limits their utility in various scenarios. This study introduces a novel frequency-stabilized laser scheme that integrates a Fabry-Perot etalon (FPE) with digital control technology and wavelength modulation techniques. The FPE, characterized by multiple transmission peaks at minimal frequency intervals, provides stable frequency references for different lasers, thereby enhancing the system's flexibility and adaptability.

Dysregulated inclusion of BOLA3 exon 3 promoted by HNRNPC accelerates the progression of esophageal squamous cell carcinoma.

Dysregulated RNA splicing events produce transcripts that facilitate esophageal squamous cell carcinoma (ESCC) progression, but how this splicing process is abnormally regulated remains elusive. Here, we unveiled a novel alternative splicing axis of BOLA3 transcripts and its regulator HNRNPC in ESCC. The long-form BOLA3 (BOLA3-L) containing exon 3 exhibited high expression levels in ESCC and was associated with poor prognosis.

Organic/inorganic heterostructures templated by interfacial instability-driven BCP colloids in deformable emulsion droplets.

Hybrid heterostructure materials have received considerable attention due to the integration of each component and abundant functional applications in micromotors, catalysis, photothermal therapy, drug delivery, and bioimaging. However, the preparation of organic/inorganic heterostructure nanoparticles (HSNPs) with high quality still remains a remarkable challenge since thermodynamically metastable structures usually coexist, resulting in a lack of organic scaffolds with extreme uniformity both in shape and size distribution. Here, we prepared polystyrene--poly(4-vinylpyridine) (PS--P4VP) block copolymer (BCP) core-shell spherical colloids driven by interfacial instability of soft and deformable emulsion droplets.

[Extraction, isolation, structural characterization and pharmacological effects of glycopeptides from traditional Chinese medicine: current status and prospects].

Glycopeptides of traditional Chinese medicine(GTCM), as a type of natural products with important biological activities, have received increasing attention in recent years. These substances have a variety of pharmacological effects, including anti-tumor, immunomodulatory, neuroprotective, and anti-inflammatory effects. The extraction and separation processes directly affect the yield and purity of GTCM, and structural characterization is essential for probing into the properties and pharmacological mechanisms of glycopeptides.

CyuR is a dual regulator for L-cysteine dependent antimicrobial resistance in Escherichia coli.

Hydrogen sulfide (HS), mainly produced from L-cysteine (Cys), renders bacteria highly resistant to oxidative stress and potentially increases antimicrobial resistance (AMR). CyuR is a Cys-dependent transcription regulator, responsible for the activation of the cyuPA operon and generation of HS. Despite its potential importance, its regulatory network remains poorly understood.

1D Anionic Covalent Organic Frameworks With Directed Migration of Alkali Metal Ions for High Ionic Conductivity.

Rational construction of high-performance ionic conductors is a critical challenge in the field of energy storage. In this study, a series of 1D anionic titanium-based covalent organic frameworks (COFs) containing abundant alkali metal ion migration sites, namely, COF-M-R (M = Li, Na, K; R = H, Me, Et), is constructed. The integration of negative TiO sites on 1D anionic COFs allows alkali metal cations to migrate directly through the channels.

Gait-Guard: Turn-aware Freezing of Gait Detection for Non-intrusive Intervention Systems.

Freezing of gait significantly reduces the quality of life for Parkinson's disease patients by increasing the risk of injurious falls and reducing mobility. Real-time intervention mechanisms promise relief from these symptoms, but require accurate real-time, portable freezing of gait detection systems to be effective. Current real-time detection systems have unacceptable false positive freezing of gait identification rates to be adopted by the patients for real-world use.

Synergistically-mediated highly-efficient visible-light-driven hydrogen evolution activity using Ohmic/Schottky-type dual-junctions and sulfur vacancy.

Enabling highly-efficient multiplex-optimization photocatalysts is critical to overcome the bottlenecks of hydrogen evolution reaction efficiency and photostability. Herein, novel CoS/S-ZnInS/MoS composites are successfully synthesized through an in situ technique. Taking advantage of the synergistic effect of sulfur vacancy, Schottky-type MoS/S-ZnInS junction and Ohmic-type CoS/S-ZnInS junction, the light absorption, electron/hole separation efficiency, charge transfer rate and hydrogen reduction reaction dynamic can be significantly enhanced.

Risk factors for in-hospital mortality in recipients of allogeneic hematopoietic stem cell transplantation with acute respiratory distress syndrome: a retrospective study based on the 2023 new definition of acute respiratory distress syndrome.

Introduction: ARDS (acute respiratory distress syndrome) is the most severe form of acute hypoxic respiratory failure. Most studies related to ARDS have excluded patients with hematologic diseases, let alone allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. Numerous patients experiencing severe hypoxic respiratory failure do not meet the Berlin definition due to the limitations of diagnosis and treatment.

Comprehensive Comparison of Three Different Medicinal Parts of DC. Using the RRLC-Q-TOF-MS-Based Metabolic Profile and In Vitro Anti-Inflammatory Activity.

DC. (EL) is a traditional Chinese herb known for its phlegm-reducing, cough-relieving and asthma-calming properties. It is widely used for treating cough and bronchitis.

Exosomal MicroRNAs modulate the cognitive function in fasudil treated APPswe/PSEN1dE9 transgenic (APP/PS1) mice model of Alzheimer's disease.

Alzheimer's disease (AD) is characterized by cognitive decline stemming from the accumulation of beta-amyloid (Aβ) plaques and the propagation of tau pathology through synapses. Exosomes, crucial mediators in neuronal development, maintenance, and intercellular communication, have gained attention in AD research. Yet, the molecular mechanisms involving exosomal miRNAs in AD remain elusive.

Risk and pathologic factors of recurrence after endoscopic resection for superficial esophageal squamous cell carcinoma: a systematic review and meta-analysis.

Background And Aims: The risk and pathologic factors of recurrence after endoscopic resection (ER) for superficial esophageal squamous cell carcinoma (ESCC) are inconsistent across studies. We evaluated this in a systematic review and meta-analysis.

Methods: The data of recurrence in such patients were extracted from all studies.

Development of esophagogastroduodenoscopy in China: results from the national census in 2013 and 2020.

Background: Given the significant burden of upper digestive diseases, there has been a substantial increase in the utilization of esophagogastroduodenoscopy (EGD) in China from 2012 to 2019. The objective of this study is to investigate the development, practice, and factors influencing the widespread use of EGD during this period.

Methods: Two national censuses were conducted among all hospitals in mainland China that perform gastrointestinal endoscopy.

CKIP-1-Loaded Cartilage-Affinitive Nanoliposomes Reverse Osteoarthritis by Restoring Chondrocyte Homeostasis.

Osteoarthritis (OA) is a chronic joint disease characterized by cartilage imbalance and disruption of cartilage extracellular matrix secretion. Identifying key genes that regulate cartilage differentiation and developing effective therapeutic strategies to restore their expression is crucial. In a previous study, we observed a significant correlation between the expression of the gene encoding casein kinase-2 interacting protein-1 (CKIP-1) in the cartilage of OA patients and OA severity scores, suggesting its potential involvement in OA development.