Impact of circadian tuning on the illuminance and color uniformity of a multichannel luminaire with spatially optimized LED placement.

Potential advantages offered by multichannel luminaires with regards to spectral tuning are frequently overshadowed by its design challenges, a major one being the non-uniformity in illuminance and color distribution. In this paper, we present a formulation using genetic algorithm (GA) to optimize the Light Emitting Diode (LED) placement, yielding 40% superior uniformity in illuminance and color distributions compared to existing analytical formulations, substantially reducing the reliance on optical design for this purpose. It is specifically shown that our approach is employable for circadian tuning applications, even when heavily constrained by industry specifications on panel size and minimum LED separation.

Automated quantification of renal interstitial fibrosis for computer-aided diagnosis: A comprehensive tissue structure segmentation method.

Unlabelled: Interstitial fibrosis in renal biopsy samples is a scarring tissue structure that may be visually quantified by pathologists as an indicator to the presence and extent of chronic kidney disease. The standard method of quantification by visual evaluation presents reproducibility issues in the diagnoses. This study proposes an automated quantification system for measuring the amount of interstitial fibrosis in renal biopsy images as a consistent basis of comparison among pathologists.