EPIDEMIOLOGY OF GENES ASSOCIATED WITH OBESITY IN ASIAN POPULATION. LITERATURE REVIEW.

Among the general population, there is a category of individuals with an innate predisposition to obesity. In recent decades, the increase in the prevalence of obesity and related diseases worldwide indicates the need to study the etiological factors associated with its development. At present, it is still unknown how many genes are involved in the pathophysiology of obesity, and many studies are underway to identify "candidate genes" in clinical medicine.

EFFICIENCY OF MOBILE APPS FOR SELF-MANAGEMENT IN TYPE II DIABETES: (REVIEW).

Diabetes affects millions of patients worldwide. Despite huge improvements in diabetes pharmacotherapy, innovations in glucose diagnosis and monitoring, and the use of insulin pumps, many people with diabetes are not meeting their glycemic control targets and would benefit from greater flexibility and more individualized diabetes management. All guidelines for the management of type II diabetes mellitus focus on lifestyle changes and self-management.

[INFLUENCE OF METFORMIN ON THE DIAMETER AND NUMBER OF DNA BREAKS IN BLOOD LYMPHOCYTES IN OBESITY].

Aim - to assess the DNA damage of lymphocytes before and after the use of Metformin in obese individuals by two indicators: the diameter and the number of DNA breaks in blood lymphocytes. The sample included 27 obese patients aged 18-61 years. Among the participants, persons with chronic decompensated diseases, with bad habits (smokers, drug users, alcohol) were excluded.

[Association of leptin with anthropometric indexes, dyslipidemia and carbohydrate metabolism in Kazakh adults].

Leptin plays an important role in eating behavior, the central action of this hormone is the regulation of appetite and energy expenditure. Anthroponutritiology as a new scientific direction uses the methods of medical anthropology and nutritional science. The study of the relationship between the regulation of energy metabolism, taking into account constitutional features, and anthropometric parameters provides relevance in this direction.

[MARKERS OF OBESITY IN CLINICAL RESEARCH AND PRACTICAL MEDICINE (REVIEW)].

The purpose of this article is to describe the state-of-the-art knowledge of risk factors and targetmarkers of obesity needed for personalization of disease prevention. The frequency of diagnosis of obesity depends to a large extent on how it is determined. In the clinical evaluation of a patient with obesity, it is necessary to assess the anthropometric, metabolic and functional status of organs and systems.

[DNA DAMAGE AND THEIR CONNECTION WITH EXCESSIVE BODY MASS AND OBESITY (REVIEW)].

The aim of this article is to describe the current level of knowledge about the relationship between overweight and genomic instability. The relationship between overweight / obesity and cancer has been well studied in numerous studies. A feature of overweight and obesity is the formation of reactive oxygen species and cytokines, which lead to damage to the genetic material of the cell.