Publications by authors named "Ye An Tan"
Background Gene-environment interactions may enhance our understanding of hypertension. Our previous study highlighted the importance of considering psychosocial factors in gene discovery for blood pressure (BP) but was limited in statistical power and population diversity. To address these challenges, we conducted a multi-population genome-wide association study (GWAS) of BP accounting for gene-depressive symptomatology (DEPR) interactions in a larger and more diverse sample.
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- Structural variants (SVs) play a crucial role in genetic differences that relate to traits and diseases, but most research has focused on European populations.
- This study compiles a catalogue of over 73,000 SVs from a diverse group of 8,392 Singaporeans, revealing that about 65% of these SVs are novel and specific to Asian ancestry groups.
- The findings help identify clinically relevant SVs and improve genetic research by addressing biases related to ancestry, which is important for equity and diversity in the field.