Publications by authors named "Yazmary Melendez-Contes"
Copper-Based Antibiotic Strategies: Exploring Applications in the Hospital Setting and the Targeting of Cu Regulatory Pathways and Current Drug Design Trends.
Aixa M Orta-Rivera Yazmary Meléndez-Contés Nataniel Medina-Berríos Adriana M Gómez-Cardona Andrés Ramos-Rodríguez
Inorganics (Basel)
June 2023
Article Synopsis
- - Classical antibacterial drugs were developed to target specific bacterial traits to minimize effects on human cells, but evolving bacteria and their resistance have created superbugs that first-line treatments can't effectively combat.
- - There is a pressing need for new antibacterial drugs, and this review explores the potential of using copper's toxicity against bacteria, as pathogenic strains have low tolerance for copper.
- - Research shows that using copper-containing materials in hospitals may reduce infections, and novel strategies targeting bacterial copper regulation could enhance treatment effectiveness, especially in combination with existing drugs.
We describe precise supramolecules that enable the evaluation of the effective hydrophobicity of amphiphilic or "patchy" nanoglobular systems. These supramolecules exhibit the lower critical solution temperature phenomenon, which provides a quantitative measure of their effective hydrophobicity. Specifically, two isomeric 8-aryl-2'-deoxyguanosine derivatives with a transposed pair of methylene groups self-assemble into hexadecameric nanoglobular supramolecular G-quadruplexes (SGQs) that show large differences in their transition temperatures as determined by turbidity and differential scanning calorimetry studies.
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