Phosphorescent metallaknots of Au(I)-bis(acetylide) strands directed by Cu(I) π-coordination.

Knots containing metal atoms as part of their continuous strand backbone are termed as metallaknots. While several metallaknots have been synthesized through one-pot self-assembly, the designed synthesis of metallaknots by controlling the arrangement of entanglements and strands connectivity remains unexplored. Here, we report the synthesis of metallaknots composed with Au(I)-bis(acetylide) linkages and templated by Cu(I) ions.

Scissor-like AuCu Cluster with Phosphorescent Mechanochromism and Thermochromism.

Reaction of [Au(tht)](ClO) (tht = tetrahydrothiophene), [Cu(CHCN)](ClO), 3,6-di--butyl-1,8-diethynyl-9-carbazole (Hdecz), and bis(2-diphenylphosphinophenyl)ether (POP) in the presence of triethylamine (NEt) gave the cluster complex AuCu(decz)(POP) as yellow crystals. As revealed by X-ray crystallography, the AuCu cluster exhibits scissor-like structure sustained by two decz and two POP ligands and stabilized by Au-Cu and Au-Au interactions. The AuCu cluster shows bright yellow to orange photoluminescence upon irradiation at >300 nm, arising from [π (decz)→5d (Au)] LMCT (ligand-to-metal charge transfer) and [π→π* (decz)] IL (intraligand) triplet states as revealed by theoretical and computational studies.

Somatic variants of MAP3K3 are sufficient to cause cerebral and spinal cord cavernous malformations.

Cerebral cavernous malformations (CCMs) and spinal cord cavernous malformations (SCCMs) are common vascular abnormalities of the CNS that can lead to seizure, haemorrhage and other neurological deficits. Approximately 85% of patients present with sporadic (versus congenital) CCMs. Somatic mutations in MAP3K3 and PIK3CA were recently reported in patients with sporadic CCM, yet it remains unknown whether MAP3K3 mutation is sufficient to induce CCMs.

Heteroctanuclear AuAg Cluster Complexes of 4,5-Diethynylacridin-9-One with Luminescent Mechanochromism.

Two heteroctanuclear AuAg cluster complexes of 4,5-diethynylacridin-9-one (HL) were prepared through the self-assembly reactions of [Au(tht)](CFSO), Ag(tht)(CFSO), HL and PPh or PPhPy (2-(diphenylphosphino)pyridine). The AuAg cluster consists of a [AuL] and four [Ag(PPh)] or [Ag(PPhPy)] units with AuL framework exhibiting a twisted paper clip structure. In CHCl solutions at ambient temperature, both compounds show ligand fluorescence at ca.

Elaborate Design of AgAu Cluster [2]Catenane Phosphors for High-Efficiency Light-Emitting Devices.

In this work, rational design of highly soluble and phosphorescent Ag-Au cluster complexes with exceptional [2]catenane structures is conducted using 1,8-diethynyl-9-carbazole (Hdecz) as a rigid U-shaped ligand with a distinguished hole-transport character. The self-assembly reaction of Hdecz, Au, and Ag generated phosphorescent AgAu cluster (Φ = 0.22 in CHCl) with Hdecz having a free ethynyl (-C≡CH) group.

Pharmacokinetics of a novel microtubule inhibitor mHA11 in rats.

mHA11, a 2-amino-4-phenyl-4H-chromene-3-carboxylate analog, is a microtubule-targeting agent discovered by our group through the modification of the Bcl-2 inhibitor HA14-1. mHA11 exhibits cytotoxicities against tumor cells with nM IC values, whereas it has only a minimal effect on normal cells. We explored the plasma pharmacokinetics, tissue distribution, and excretion of mHA11 in rats using a liquid chromatography/tandem mass spectrometry (LC-MS/MS) method.

Silver(i) nanoclusters of carbazole-1,8-bis(acetylide): from visible to near-infrared emission.

A feasible synthetic approach to achieve Ag8, Ag16 and Ag29 silver(i) nanoclusters is reported by the use of 1,8-diethynyl-9H-carbazole (H3decz) as a directing ligand. The silver(i) nanoclusters exhibit room-temperature photoluminescence in both solution and solid state. The emission band shows stepwise red-shifts from visible to near-infrared region with the increase of cluster nuclearity following 2 (Ag8, λem = 571 nm) → 3 (Ag16, λem = 651 nm) → 4 (Ag29, λem = 916 and 875sh nm) in fluid CH2Cl2.

Peroxisome Proliferator-Activated Receptor γ Regulates the Expression of Lipid Phosphate Phosphohydrolase 1 in Human Vascular Endothelial Cells.

Lipid phosphate phosphohydrolase 1 (LPP1), a membrane ectophosphohydrolase regulating the availability of bioactive lipid phosphates, plays important roles in cellular signaling and physiological processes such as angiogenesis and endothelial migration. However, the regulated expression of LPP1 remains largely unknown. Here, we aimed to examine a role of peroxisome proliferator-activated receptor γ (PPAR γ ) in the transcriptional control of LPP1 gene expression.